george davey smith
@mendel_random
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Joined February 2012
1/n A webinar from @CDC_Genomics on Mendelian randomization (MR) highlights some under-appreciated aspects of MR; this thread outlines these
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RT @CAMBRIDGE_CEU: 🎉 Huge congratulations to @amymariemason – voted Most Popular Mathematician in I’m a Mathematician 2025! 🏆.She’s taken….
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RT @evans1_d: Investigating potential causal effects of maternal smoking on offspring handedness using a proxy gene-by-environment (GxE) Me….
link.springer.com
Behavior Genetics - Hand preference first appears in early development, yet twin studies and GWAS show that only a minority of variance is explained by heritable genetic factors. Using UK Biobank...
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RT @mendel_random: 2/n according to @yudapearl application of the front door criteria will become a "serious competitor to RCTs". To make s….
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RT @mendel_random: @JohannesTextor @statsepi @MariaGlymour @yudapearl the very antithesis of this notion of combining evidence from differe….
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RT @MAbsoud: Really important reply on recent claims being made in the Covid inquiry by some unelected/ unaccountable scientists. importa….
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RT @MAbsoud: Absolutely NO causal relationships can be drawn from this paper due to the high risk of selection bias in the design. The 'c….
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Triangulation of evidence in medical research explained, in work led by @SirenaGtz and @MariaGlymour.Will do a thread when I get the time.
link.springer.com
European Journal of Epidemiology - For many important questions about influences on clinical and public health outcomes, no single study can provide a decisive answer. The perfect study—a...
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My favourite visual representation of Mendelism is below, but as always the story is more complex than it seems
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Reposted with suggested listening for playing when reading the editorial
The advent of Mendelian randomization followed the myriad cases of observational studies suggesting vitamins would prevent many diseases, with RCTs quashing these hopes. Sadly fallible MR methods simply recapitulate the spurious epidemiological findings
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The advent of Mendelian randomization followed the myriad cases of observational studies suggesting vitamins would prevent many diseases, with RCTs quashing these hopes. Sadly fallible MR methods simply recapitulate the spurious epidemiological findings
academic.oup.com
Our editorial responsibility for the International Journal of Epidemiology (IJE) started at the dawn of the current millennium, and we marked the occasion
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RT @mendel_random: It’s 5 years from intensification of covid policy in the UK, and the mantra of “lives vs economy” becoming common place.….
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It’s 5 years from intensification of covid policy in the UK, and the mantra of “lives vs economy” becoming common place. Here a long thread from soon after, reflecting on the fact that there was so much more at stake that “lives vs economy”. It was “lives vs lives” that mattered.
1/n “lives vs economy” is unhelpful, it is not primarily the economy and jobs that are diminished by full or partial lockdowns, rather the almost unimaginable richness of life in all its domains suffers. We are social beings, and a major part of that sociality is stripped from us.
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Thought for the day, from Conrad Waddington in 1969 “Life might be defined as the art of getting away with it; and Theoretical Biology as the attempt painstakingly to explicate just how it is done”
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the "butter bad dark chocolate bad" authors have been producing nonsense for 40 years . see and
A new study comparing butter to vegetable oil for risk of death made all the headlines this week. What did they find and what does it mean?. full video below🔽
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RT @macordero: Se lanza la 3ra Edición del libro que formalizó un enfoque de curso de vida para la epidemiología contemporánea 👇🏽.
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Lifecourse epidemiology debuted in 1997 with “A Lifecourse Approach to Chronic Disease Epidemiology” edited by Di Kuh & Yoav Ben-Shlomo. The 3rd edition of the ground breaking book is being launched 12 March 15.30 UK time & foreword
bristol.ac.uk
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Is there a future for Mendelian randomization? 10th March 11.00 Canadian time, online and in person @mcgillu, I'll discuss this and why, if I had been better read, I would have used the term "meiotic randomization" rather than "Mendelian randomization".in the initial papers
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Contralateral cancers are an enigma: the unaffected organ is perfectly matched on exposures across life. Yet at older ages, risk of cancer in the unaffected organ is not much higher than in a randomly selected organ from the same population. How & why?
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