Richard Sever
@cshperspectives
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Chief Science and Strategy Officer, openRxiv. bioRxiv & medRxiv Co-Founder
New York
Joined February 2009
Big new article from me in @PLOSBiology on the past, present and future of science publishing. 6n š§µ on what I try to do here. (RTs appreciated). 1/n https://t.co/QSVrHMWZEz
journals.plos.org
Academic journals have been publishing the results of biomedical research for more than 350 years. Reviewing their history reveals that the ways in which journals vet submissions have changed over...
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Many scientists (including me) have viewed AI review warily. But responses to trials of qed have been very positive. I was impressed with its output, which was developed by iteration with a large number of human reviewers. 3/n
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Donald & Melania Trump Snow Globe New White House Edition Now Available Place It In Your House This Holiday Season
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Authors can now send papers directly from bioRxiv to qed and get feedback on improvements they should make ā āgapsā that require more work or revision of the claims. 2/n
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Excited to launch an openRxiv partnership with the scientist-run AI review service qed science, the brainchild of @OdedRechavi
https://t.co/QOhJIsoDj9 1/n
openrxiv.org
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspeciali...
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āabove all, we adjust to a new reality where volume matters less than the substanceā
Itās disappointing how precarious the commitment is to author-driven publishing, even by supporters. The moment we get uncomfortable, we retreat squarely into pre-publication peer review. No one will save us from a flood of content, AI generated or otherwise. No one should
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On metrics in hiring..
@GonzaParra_ IME they rarely come up, and if they do itās usually in the context of someone lobbying for a candidate they like for other reasons. And they rarely matter to anyone.
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Iā¤ļøNY
The majority of the No Kings protests have dispersed at this time and all traffic closures have been lifted.Ā We had more than 100,000 people across all five boroughs peacefully exercising their first amendment rights and the NYPD made zero protest-related arrests.
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New blog post. In which I analyze the new HHMI announcement and what it means for the science publishing ecosystem
openrxiv.org
By Richard Sever, PhD. Chief Science & Strategy Officer, openRxiv Preprints speed up science by enabling researchers to disseminate reports of new findings immediately. They also represent a simple...
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If you are are preprint-curious and need a little guidance, just reply here. We (the community wanting to help) will send the cavalry to answer your questions and help you navigate your first preprint
Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved
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Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved
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bioRxiv has a dedicated section for negative results. Use it. Share negative results. Your colleagues will appreciate it.
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Extrapolating curves where the y and x axis have no causal relationship is exactly the kind of bogus predictions folks made during the pandemic. 2/
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- abstract sounds very familiar but no access - ask chatGPT if this was a preprint. It says no based on title - ask chatGPT to use the abstract, authors, references and it finds it instantly under a different title - preprint posted a full year ago so could be used, tested,
biorxiv.org
Protein-protein interactions (PPI) are essential for biological function. Recent advances in coevolutionary analysis and Deep Learning (DL) based protein structure prediction have enabled comprehen...
ššA new David Baker paper from @ScienceMagazine is hereš Can deep learning models finally overcome the massive computational challenge of predicting which 200 million possible human protein pairs actually interact in living cells?@UWproteindesign @UTSWMedCenter "Predicting
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To better understand the HHMI preprint mandate, read the @PLOSBiology article on Plan U by @cshperspectives and colleagues. Plan U: Universal access to scientific and medical research via funder preprint mandates https://t.co/7xQtNU1RJA
journals.plos.org
Preprint servers are a low-cost mechanism for providing free access to research findings, and can also significantly accelerate research itself by making results available immediately. This Perspec...
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Link for HHMI preprint mandate
HHMI adopts Plan U
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This is truly an incredible breakthrough IMO. Really exemplifies what you get when deep domain expertise (population/disease genetics in this case) fuses with cleverly crafted ML. What u get r sleek, well thought out architectures that absolutely destroy the behemoths. Wow!! 1/
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. https://t.co/FTm3byYp67 (1/n)
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One simple swap you need to make for a better breakfast:
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@JennGuerriero Like clusters in scRNAseq, categories of the mind or, better, latent variables in a statistical model. They don't exist in reality, only in our models, simplifications of reality built for a purpose. It's up to us to show they are useful for that purpose, not just fit the model.
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openRxiv response to the NIH RFI: NIH should provide public access by mandating preprints https://t.co/DjQtw52dbd
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@jonkay I have a few remaining very senior colleagues who managed paralyzed polio patients in āiron lungā wards in the 1950s - when they were young MDs. These guys are in their 90s now and among the most pro vaccine people you will ever meetā¦
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At first, itās just a tool. But over time, the wheel balancer becomes essentialāmaking sure every wheel is perfectly balanced, every ride is smooth, and every turn is precise. Itās the hidden hero that ensures your tires last longer, and your drive stays steady.
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