Richard Sever
@cshperspectives
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Chief Science and Strategy Officer, openRxiv. bioRxiv & medRxiv Co-Founder
New York
Joined February 2009
Big new article from me in @PLOSBiology on the past, present and future of science publishing. 6n 𧾠on what I try to do here. (RTs appreciated). 1/n https://t.co/QSVrHMWZEz
journals.plos.org
Academic journals have been publishing the results of biomedical research for more than 350 years. Reviewing their history reveals that the ways in which journals vet submissions have changed over...
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On metrics in hiring..
@GonzaParra_ IME they rarely come up, and if they do itâs usually in the context of someone lobbying for a candidate they like for other reasons. And they rarely matter to anyone.
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Riot Platforms Reports Third Quarter 2025 Financial Results and Strategic Highlights. - Record quarterly revenue of $180.2 million - Net income of $104.5 million, or $0.26 diluted EPS - Adjusted EBITDA of $197.2 million - Announces initiation of 112 MW of core and shell for data
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Iâ¤ď¸NY
The majority of the No Kings protests have dispersed at this time and all traffic closures have been lifted. We had more than 100,000 people across all five boroughs peacefully exercising their first amendment rights and the NYPD made zero protest-related arrests.
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New blog post. In which I analyze the new HHMI announcement and what it means for the science publishing ecosystem
openrxiv.org
By Richard Sever, PhD. Chief Science & Strategy Officer, openRxiv Preprints speed up science by enabling researchers to disseminate reports of new findings immediately. They also represent a simple...
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If you are are preprint-curious and need a little guidance, just reply here. We (the community wanting to help) will send the cavalry to answer your questions and help you navigate your first preprint
Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved
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Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved
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bioRxiv has a dedicated section for negative results. Use it. Share negative results. Your colleagues will appreciate it.
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Extrapolating curves where the y and x axis have no causal relationship is exactly the kind of bogus predictions folks made during the pandemic. 2/
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- abstract sounds very familiar but no access - ask chatGPT if this was a preprint. It says no based on title - ask chatGPT to use the abstract, authors, references and it finds it instantly under a different title - preprint posted a full year ago so could be used, tested,
biorxiv.org
Protein-protein interactions (PPI) are essential for biological function. Recent advances in coevolutionary analysis and Deep Learning (DL) based protein structure prediction have enabled comprehen...
đđA new David Baker paper from @ScienceMagazine is heređ Can deep learning models finally overcome the massive computational challenge of predicting which 200 million possible human protein pairs actually interact in living cells?@UWproteindesign @UTSWMedCenter "Predicting
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To better understand the HHMI preprint mandate, read the @PLOSBiology article on Plan U by @cshperspectives and colleagues. Plan U: Universal access to scientific and medical research via funder preprint mandates https://t.co/7xQtNU1RJA
journals.plos.org
Preprint servers are a low-cost mechanism for providing free access to research findings, and can also significantly accelerate research itself by making results available immediately. This Perspec...
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Link for HHMI preprint mandate
HHMI adopts Plan U
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This is truly an incredible breakthrough IMO. Really exemplifies what you get when deep domain expertise (population/disease genetics in this case) fuses with cleverly crafted ML. What u get r sleek, well thought out architectures that absolutely destroy the behemoths. Wow!! 1/
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. https://t.co/FTm3byYp67 (1/n)
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@JennGuerriero Like clusters in scRNAseq, categories of the mind or, better, latent variables in a statistical model. They don't exist in reality, only in our models, simplifications of reality built for a purpose. It's up to us to show they are useful for that purpose, not just fit the model.
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openRxiv response to the NIH RFI: NIH should provide public access by mandating preprints https://t.co/DjQtw52dbd
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@jonkay I have a few remaining very senior colleagues who managed paralyzed polio patients in âiron lungâ wards in the 1950s - when they were young MDs. These guys are in their 90s now and among the most pro vaccine people you will ever meetâŚ
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bioRxiv bat signal. We had a huge influx of submissions around Labor Day and now have a back log. If any affiliates are available to screen, we'd be eternally grateful!
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Funder information can now be added to bioRxiv preprints. Incorporation of funding organizations into the Research Organization Registry (ROR) means this is available as standardized metadata for articles. https://t.co/kaky4nLcc2
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đĽ Exclusive Interview with Processa Pharmaceuticals CEO George Ng Processa $PCSA is taking a bold approach to oncology: modifying FDA-approved cancer drugs to create safer, more effective treatments through its Next Generation Cancer (NGC) pipeline. Why Investors Should Watch:
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Mitochondria didnât deserve this. Krebs cycle on the other handâŚ
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Very honored to receive the Royal Society Research Culture Award - this represents the work of a great team who've worked non-stop since we launched bioRxiv in 2013 https://t.co/oLwFLoes2m
cshl.edu
Cold Spring Harbor Laboratoryâs (CSHLâs) John Inglis and Richard Sever have earned The Royal Societyâs 2025 Research Culture Award. The two were honored for cofounding the preeminent biomedical...
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