Maddy Smith
@maddy_epi
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Wellcome Trust PhD Student @ Uni of Bristol MRC Integrative Epidemiology Unit // 🔎obesity/metabolites/NCDs
Joined April 2021
Nice to see our paper out in @SciReports. We used data from two weight loss trials (@ByBandSleeve and the Diabetes Remission Clinical Trial) to explore the effects on circulating proteins. https://t.co/jXGY28K8O9 1/4
nature.com
Scientific Reports - Using trials of caloric restriction and bariatric surgery to explore the effects of body mass index on the circulating proteome
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I wrote a blog post about my experience attending and presenting at #EASD2023 this month! Read it here:
PhD student @maddy_epi discusses the interface between diabetes research and clinical practice in reflections from the recent #easd2023 conference. https://t.co/NlEzarUuUN
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We had a wonderful array of discussions today at our Standing up for Science workshop! Thank you for your expert insights and advice for ECRs @Jackstilgoe @profmarkmaslin @rozeggo @RachMBuch @anjahuja @FrancaDavenport @prateekbuch @PhysicsNews @LeonieC
https://t.co/2OSAjiviwI
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Delighted to see our work on the metabolic features of genetic liability to type 2 diabetes and coronary artery disease published in @eBioMedicine today! @joshuaa_bell @emmylooroll @caroline_bull @ECSanderson @mendel_random @mvholmes
https://t.co/6cSlFrVRhI
thelancet.com
Overall, our results support largely distinct metabolic features of genetic liability to T2D and CAD, illustrating both challenges and opportunities for preventing these commonly co-occurring...
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Excited to see this paper now published in @JTHjournal
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Enjoying sunny Edinburgh and the @megukepi conference. Great talk from @EpiHazelwood on weight loss and colorectal cancer risk and @maddy_epi talking later about weight loss and the metabolome!
@genscot Look out for the Bristol gang @lucygoudswaard @maddy_epi & #emma_hazelwood #andrei_constantinescu
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PhD student @maddy_epi will be presenting her research about the long-term metabolomic effects of bariatric surgery, which uses samples from BBS participants, at the @megukepi annual meeting in Edinburgh next week.
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Our data note describing the inflammation proteomics dataset measured by @OlinkProteomics in 9000 @CO90s participants is now out in @WellcomeOpenRes
https://t.co/EclETdfD9X 1/3
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Glad to see our study exploring the effect of COVID-19 on platelet function as a preprint! Link: https://t.co/etzcIubw1p 1/6
biorxiv.org
Background Patients with coronavirus disease-19 (COVID-19) are at increased risk of thrombosis, which is associated with altered platelet function and coagulopathy, contributing to excess mortality....
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I'm glad to announce that our polygenic score-metabolite atlas has been published on @eLife 🥳 This atlas contains associations between 125 PGS for complex traits and 249 NMR-derived metabolic traits from up to 83,004 individuals in the UK Biobank.
elifesciences.org
A comprehensive resource to systematically evaluate the genetically predicted associations between 125 polygenic risk scores and 249 metabolic traits.
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New #OpenAccess paper published using @CO90s data: #SocioeconomicPosition & #AdverseChildhoodExperiences as risk factors for health-related #BehaviorChange & #EmploymentAdversity during #COVID19pandemic @maddy_epi published in @BMC_series @BioMedCentral
bmcpublichealth.biomedcentral.com
Background Non-pharmaceutical interventions to reduce the spread of COVID-19 may have disproportionately affected already disadvantaged populations. Methods We analysed data from 2710 young adult...
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We have another great talk this month in @DEMONNetworkUK biomarkers working group. @maddy_epi and Hannah Compton will be telling us about Metabolomic signatures of genetic liability to Alzheimer's disease. Wed 10am BST.
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📣 New paper out now in @JAHA_AHA! 📣 We show that drinking alcohol during pregnancy is associated with a lower risk of hypertensive disorders of pregnancy (HDP) ... and explain why we *don't* think this reflects a true causal effect 🤰🍷 (1/4) https://t.co/A1PixBc4SC
ahajournals.org
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Our results highlight the economic adversity experienced by those with a history of ACEs during the lockdown measures (job loss, furlough etc.) - few interventions currently target this group and lockdown may have exacerbated their needs. 3/3
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We used ALSPAC data (@CO90s) to look at the effects of low socioeconomic position and a history of adverse childhood experiences (ACEs) on young adults' lives during the first UK lockdown back in March 2020 2/3
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Today I'm celebrating the publication of my first first author paper! This project doubled as an intro to epidemiology for me and I learned so much from my fab supervisors on this one - thank you @laurahowe_epi @AnnieSHerbert @ammhughes
https://t.co/n3Im7tSD7t 1/3
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Fab few days in Paris at #IGES22 with a lovely bunch of people. Especially enjoyed presenting my reverse-MR work at the poster session this afternoon 🧬
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Such a great cohort of @mrc_ieu PhD candidates, well done at #IGES22! @FMBerstein, @Ciarrah_, @HelenaUrquijo,@marina_vab, @_andreicon, @maddy_epi, Panagiota Pagoni, Genevieve Leyden. And Drs @Nancymc31 and @jamesyrmsk
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Finally: causal estimates for adiposity & metabolomic traits at scale! Pleased to share the first large-scale comparison of conventional vs MR approaches in UK Biobank in @LancetRH_Europe
https://t.co/FfQboXmpA9 Key takeaways:
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Really enjoying #MetSoc2022 so far… Great to be abroad for the first time in 3 years and to be discussing all things #Metabolomics! There’s still time to see my poster about the metabolomic effects of bariatric surgery between 5 and 6.30pm today - no.382 in auditorium 3
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