Richard G. James
@ScienceRicker
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Principal investigator at Seattle Children's. We study B cell development, immunological disease and response to therapy. https://t.co/qwTAcNrW55
Seattle, WA
Joined December 2017
Thanks to the amazing Iana Meitlis who is in UW Med school, Eric Allenspach, Andrew Snow and Dave Rawlings. These methods were based on work by @jshendure, @lea_starita, @TheNobleDust.
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RT @dinodicarlo: @slavov_n @ScienceMagazine Please take a look at this manuscript in collaboration with @ScienceRicker that also shows one….
biorxiv.org
Protein secretion drives many functions in vivo ; however, methods to link secretions with surface markers and transcriptomes have been lacking. By accumulating secretions close to secreting cells...
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RT @bebiopharma: New research published in @NatureComms from our co-founders Drs. @ScienceRicker and David Rawlings from @seattlechildren s….
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RT @kinglhung: Very happy to see the full story out finally. We had been sitting on some of these exciting findings since 2017! (6/6).
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RT @psmibert: A really cool application of Partillion Biosciences and @10xGenomics technologies to measure secreted proteins together with….
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RT @LongwoodFund: Congratulations to @bebiopharma on the Series B! This Longwood-founded company is making progress in developing a new cla….
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RT @amermathsoc: Bianca Viray, a professor @UW, has been awarded the AMS Joan and Joseph Birman Fellowship for Women Scholars for the 2022–….
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RT @BrotmanBaty: Join our team!.DIRECTOR OF MUTATIONAL SCANNING.This person will lead a team to help bring mutational scanning methods to p….
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RT @BalazsLab: Until the pre-print posts, I figured I would put together a thread for those who want to see the data. Many thanks to @wilfr….
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RT @kinglhung: Today we release in @biorxivpreprint a method for isolating megabase-sized, oncogenic extrachromosomal DNA from human cancer….
biorxiv.org
Extrachromosomal DNA (ecDNA) is a common mode of oncogene amplification but is challenging to analyze. Here, we present a method for targeted purification of megabase-sized ecDNA by combining...
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RT @kinglhung: Our paper is out in @Nature! Extrachromosomal DNA molecules huddle together in cancer cells to activate oncogene expression….
nature.com
Nature - Extrachromosomal DNA (ecDNA) congregates in clusters called ecDNA hubs that promote intermolecular interactions between gene-regulatory regions and thereby amplify the expression of...
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RT @bebiopharma: B cells are nature’s medicine factories built to unleash a variety of therapeutic applications. Hear our scientific co-fou….
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RT @lea_starita: Congrats to the hubs, @ScienceRicker, for cofounding @bebiopharma, over zoom, while simultaneously home schooling 6th grad….
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Your work started @kinglhung - we are super excited to keep it moving forward!.
So glad to see that this is gaining traction!.
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Excited to share our functional data that has helped classify VUS associated with immune dysregulation at #CIS2021 - what a great meeting! Check it out.
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RT @bebiopharma: Thrilled to announce the appointment of Joanne Smith-Farrell and Rick Morgan to the leadership team at Be Bio! . https://t.….
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RT @jbloom_lab: In new work led by @AllieGreaney, we analyze mutational escape of #SARSCoV2 from monoclonal & polyclonal antibodies in term….
biorxiv.org
Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions of these different antibody classes to...
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RT @jbloom_lab: Finally, enjoyable part of project was getting to build on nice prior work by @cobarnes27 @bjorkmanlab @NussenzweigL @PaulB….
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