The Single-Cell Ninjas
@Sc_Ninjas
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Disseminating knowledge about single-cell technology. Like/RT ≠ endorse
Joined April 2021
New in Nature Reviews Genetics: my Review on how advanced genomic technologies are redefining cellular reprogramming: mapping trajectories, dissecting chromatin dynamics, + lineage tracing & synthetic circuits to push the boundaries of cell identity. https://t.co/8NBM5ohxkJ
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BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 It started from my frustration with the depressing effect that the current publishing system has
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@AnnaEnim @CellGenomics @LGMartelotto @JudeNicho @NIH @BWFUND It’s a fantastic technique. Easily the best genotyping + RNA technique available at the moment. Do not sleep on this one!!! Great work @AnnaEnim and @LGMartelotto
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RT @LGMartelotto: YES!!! It’s out! 🔥 One of the most amazingly beautiful collaborations. I’ve admired @AnnaEnim since her original GoT -…
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RT @LGMartelotto: Very happy to start my new position at @BDBiosciences! What an exciting time to keep innovating in single-cell and beyo…
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Mi amigo Chris - @mason_lab, a legend through and through - dives into his lifelong love for genetics, from the Human Genome Project to some of the coolest omics projects on the planet (and off it). He’s the mastermind behind mapping the NYC subway microbiome (hero status
genomeweb.com
Mason likens the path to interplanetary genomics to the building of cathedrals in the Middle Ages: "It's bigger than you, it's kind of humbling in a way."
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When your science heroes come to your playground @StJudeResearch 😀🎉 @RongFan8 @LGMartelotto
#bridgingchemistrytomedicine
#singlecell #spatialbiology #chemistry #medicine #ai #machinelearning #cancerresearch #multiomics #genetics #epigenome #science @CellPressNews
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Our RAEFISH spatial transcriptomics technology is now published in Cell @CellCellPress! RAEFISH enables sequencing-free whole genome spatial transcriptomics at single molecule resolution. This work represents the first time that transcripts from more than 23,000 genes were
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@Xiaojie_Qiu @CellCellPress Thank you for your very kind words, Xiaojie! We think this should be compatible with most, if not all, image-based spatial transcriptomic instruments out there, so this should be quite adaptable. Looking forward to collaborating with you and your team too!
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Spatial transcriptomics often raises recurring questions…why do some samples show so few genes, is expression too low, or are we just seeing poor quality tissue? @BrantBassamPhD digs into a unique dataset of 210 CosMx SMI experiments across human, mouse, and primate tissues to
linkedin.com
There are questions in Spatial Transcriptomics (ST) that come up time and again. Questions like “shouldn’t there be more genes expressing?,” “is the level of expression too low to be useful?,” and...
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Loving this… circVDJ-seq for T cell clonotype detection in single-cell and spatial multi-omics | bioRxiv circVDJ-seq for T cell clonotype detection in single-cell and spatial multi-omics | bioRxiv
biorxiv.org
Monitoring T cell clonality in human tissues provides important insights into adaptive immune response mechanisms in cancer, infectious diseases, and autoimmunity. However, retrieving VDJ sequence...
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China's BGI Unveils Stereo-cell Technology, Expanding Single-Cell and Spatial Arsenal | GenomeWeb STAMP is versatile, platform agnostic, multiomics enabled, multioplexing capabilities and leverages top-notch R&D teams across multiple vendors..
genomeweb.com
Building on BGI's proprietary DNBSeq technology, Stereo-cell is highly similar to Stereo-seq in workflow while promising to be unbiased and scalable.
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Only single cell sequencing of the all these post docs will reveal why
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RT @LGMartelotto: Yes, you can very likely plug this into Single Cell Imaging - #STAMP: Single-cell Transcriptomics Analysis and Multimodal…
lnkd.in
This link will take you to a page that’s not on LinkedIn
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Amazing new paper from @nicholas_navin’s lab! Coalescing single-cell genomes and transcriptomes to decode breast cancer progression: Cell
cell.com
wellDR-seq allows single-cell whole-genome and transcriptome co-profiling at scale, enabling dissections of complex relationships between copy-number alterations and gene expression that inform our...
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Our paper identifying evidence of off-target probe binding in the 10x Genomics Xenium Breast Gene Panel is now available as a reviewed preprint at #eLife
https://t.co/dQ9FqTMCdY We look forward to revising the paper to incorporate reviewer recommendations and other updates 🧵👇
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Very proud of these two! Kellie Wise (@Kellieiswise) Anna Pascual-Reguant @DrJasPlummer @hoheyn
@cnag_eu @StJudeResearch
#STAMP Imaging-based multimodal profiling of single cells with STAMP | Nature Reviews Genetics https://t.co/Cs975RuX9w
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One of the most prolific investigators in the area of single cell genomics is a free agent on the market. 👀 Good luck to @LGMartelotto for his next landing spot…. Maybe the 🇺🇸 can get him back!
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