Steve Jackson Lab
@SPJacksonGroup
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Our research focuses on the DNA damage response and its links to health and disease
Cambridge, UK
Joined January 2014
We are so excited to see this collaboration now published.
Happy to share that our recent work on the role of USP37 in counteracting the ubiquitylation and premature disassembly of stressed replisomes by TRAIP is now out. A fantastic collaboration with Olga Kochenova in @FrogWalterLab,@GS_Lab_Bham,@SPJacksonGroup
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Our Simon Lam developed the user-friendly web portal to freely share this map of interactions, making this a global resource for all, to help identify therapeutic targets for cancer and other DDR-related diseases.
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Thrilled to see this “veritable tour de force” led by @John_C_Fielden from @jcornlab out @nature, This @ERC_Research funded project uses #CRISPRi to systematically scan 548 DDR genes for synthetic lethal interactions, ~150,000 pairwise combinations!.
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RT @luijsterburglab: A must for all DNA repair aficionados!. Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱.✔️ Confirmed top speakers.✔️….
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Exciting opportunity for @ASTARsg student @GangGoh to exchange new ideas on #CRISPR and #BaseEditing with @SPJacksonGroup members past @durocherlab, and present #CRISPR25 @eventsWCS
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@jordancjwilson @TheCIMR @villunger @ERC_Research @jcornlab @LoizouJoanna We also acknowledge the partner publication from the Van Vugt Lab @researchumcg and @durocherlab,
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Excited to share our preprint, work spearheaded by PhD student @jordancjwilson with Marciniak Lab @TheCIMR, @villunger & our @ERC_Research partners @jcornlab & @LoizouJoanna. This sheds light on the action of WEE1 inhibitors and their therapeutic use,
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Early bird registration deadline less than two months away. Check out this great line up @TheBACR 65th Anniversary Meeting.
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RT @eventsWCS: Present your CRISPR research on a global stage!🧬✂️. Share your #GeneEditing insights with peers interested in learning more….
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Don't miss this opportunity to learn about #CRISPR from world experts including Thijn Brummelkamp @NKI_nl, @durocher1, @erika_alden_d, @LeopoldParts @sangerinstitute and Weixin Tang @UChiChemistry. Bursary application deadline 14 Jan, abstract deadline 4 Feb. Tell your friends!.
Make your mark on the future of #PrecisionMedicine at #CRISPR25. Showcase #CRISPR methods for modulating the genome at scale🧬. Submit an abstract by 4 February for an opportunity to build your professional profile at the forefront of a global community. 📎
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This exciting novel discovery, published in @NatureComms, with contributions from the Balasubramanian lab @ChemCambridge, was supported by @CR_UK, @TheMarkFdn, @wellcometrust and @ERC_Research.
Happy to share our newly published article in Nature Communications! In this work, we uncover the novel role of KLF5 in sensitizing cells to ATR inhibition, identifying it as a synthetic lethal partner with the tumor suppressor ARID1A. @SPJacksonGroup .
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RT @CRUKCamBreast: 📡Registration is open for the Cambridge Precision Breast Cancer Symposium on 28 March! We are excited to have another st….
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And there's more, a vacancy for a Higher Scientific Officer, it must be Christmas!
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Calling all #PhDs and #postdocs. Not one, not two but THREE #Postdocs opportunities with @LoizouJoanna @ICR_London. All details here, here and here
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Our new paper led by @ASTARsg PhD student @GangGoh, uncovers a TDP1 splice-site mutation that makes HAP1 cells hypersensitive to #Topoisomerase I inhibitors. Find out how this could impact your #CRISPR screens and use of HAP1 cells @NAR_Open,
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We are excited to share this new review, everything you ever wanted to know about transcription-coupled DPC repair from leaders in the field @cjcarnie and @stingele_lab.
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Now out in @GenomeMedicine @BioMedCentral. Transform your #crispr screens with "Exorcise", EXOme-guided Re-annotation of nuCleotIde SEquences,
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