Check out latest from the Walter-Pellman collaboration, revealing how the replisome is remodeled in mitosis to allow CMG eviction, which we propose minimizes fallout from under-replication.

Complementary work on USP37 from the Labib and Emanuele labs.

Thrilled to share our new finding that the DUB USP37 suppresses rogue ubiquitylation and disassembly of stressed replisomes by TRAIP. Fantastic collaboration between Olga Kochenova in my lab and Giusi D’Alessandro in Steve Jackson’s lab! Read all about it:

Great to see that, as we found in egg extracts, STK19 is also integral to TC-NER in human cells!.

We recapitulated transcription-coupled repair in frog egg extracts and showed that STK19 couples stalled RNAPII to repair. Tour de force by @TychoMevissen (seeking PI positions, grab him if you can!), and key contribution from Lucas Farnung and team.

Please RT: The Walter lab at Harvard seeks computational biologists to extend our work using AlphaFold to find new protein-protein interactions. Contact johannes_walter@hms.harvard.edu.

A warm thank you to Lumír Krejčí for hosting my Mendel lecture in Brno, Czech Republic, home of a vibrant scientific community, the marvelous Tugendhat Villa, and of course, Gregor Mendel. To stream Mendel lectures:

Excited to share (with my 8 followers) graduate student Ernst Schmid’s “SPOC” classifier, which can pick a good AlphaFold-Multimer prediction out of a crowd, and a database of PPIs in the genome maintenance space.

Comprehensive model of how the replisome bypasses G4 quadruplexes. Intricate mechanism involving one accessory helicase that helps CMG bypass the G4, and a second helicase that subsequently unfolds the G4 for nascent strand extension. Beautiful work!.