Ruth Raichur
@RuthRaichur
Followers
88
Following
336
Media
0
Statuses
30
Ph.D. student @weillcornellgs | prev @insitubiology @broadinstitute | B.S. @texasscience
New York, NY
Joined February 2022
Thrilled to be starting my PhD in the BCMB program at @WeillCornellGS this fall! Grateful for the incredible mentorship at @insitubiology (@immunoliugy, @hattaca, @AndyRusss + others) and @TexasScience; couldn't have done it without their support. Excited for the journey ahead!
2
1
42
"Rizz-ard of Oz: There's no place like lab"! Thanks @genomics212 for the annual halloween party!
0
1
3
TissueMosaic, our method to study how changes in tissue structure across conditions affect cell-intrinsic function, is now out @CellSystemsCP! https://t.co/ctFE33aFPP
cell.com
Kambhampati et al. develop TissueMosaic, a self-supervised convolutional framework that discovers recurring tissue architectural motifs from spatial transcriptomics data. TissueMosiac links motifs to...
2
5
19
Check out our new method of spatial transcriptomics with computational reconstruction on @NatureBiotech. Make spatial transcriptomics easier and more accessible. https://t.co/pPMC4V6ve3
2
22
76
1/ Thrilled to share an advancement in gene therapy from my PhD in @NatureComms! We've developed a new approach to reduce immune responses while maintaining efficiency—paving the way for safer, more effective therapies. Big thanks to @zhangf & @mircoscopy! https://t.co/eXZkpgiMXq
2
33
127
Grateful to have been included in this incredible project, alongside such an amazing team!
Excited to share our lab's first preprint: we used spatial transcriptomics to dissect how aging disrupts the cycling ovary! 🧵 This was an incredible team effort w/ @jenngarrison @Tammyinlab @davidsebfischer AlisonKochersberger @RuthRaichur @sophiamszady
0
1
17
We are excited to publish a spatially resolved single-cell multi-omic census of the placenta, contributing to the @humancellatlas project. The placenta plays an essential role in maintaining a healthy pregnancy, yet its function remains poorly understood.
10
30
114
We’re excited to share our latest computational method, TissueMosaic, for comparative analysis of spatial transcriptomic datasets across conditions! (1/5) https://t.co/uytkq4jRib
biorxiv.org
Spatial transcriptomics allows for the measurement of gene expression within native tissue context, thereby improving our understanding of how cell states are modulated by their microenvironment....
3
14
51
Pretty normal Thursday in the lab ... #placentasinspace #placentasinorbit #reproductiveimmunologyonthemoon Thank you @genomics212 for the fun party!
0
1
23
Check out this awesome new spatial lineage tracing paper from @MattG_Jones @sundakao @dianyang1117! One of the coolest uses of Slide-tags yet. Was a pleasure to help out.
I'm thrilled to share our new study of the spatial evolution of Kras;p53-driven mouse lung adenocarcinoma! It's been fantastic leading this with @dianyang1117 & @sundakao, and enjoying a long-standing collaboration with @JswLab @YosefLab & @insitubiology.
1
1
19
Our paper on continuous mutagenesis in living cells using HACE is now out in @ScienceMagazine! We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks. https://t.co/2h7Skln60Q
science.org
Deciphering the context-specific relationship between sequence and function is a major challenge in genomics. Existing tools for inducing locus-specific hypermutation and evolution in the native...
23
66
352
New review & podcast alert! Our latest review in @AnnualReviews delves into maternal B cell tolerance to the placenta & fetus. Check it out here: https://t.co/Sj4lNNeZLj (1/4)
annualreviews.org
Pregnancy has fascinated immunologists ever since Peter Medawar's observation that reproduction runs contrary to the founding tenets of immunology. During healthy pregnancy, maternal B cells interact...
1
6
21
7 years ago, I met a junior fellow named @JD_Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (@ajaylabade31, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/
11
229
871
With reconstruction, we can do Slide-seq/Slide-tags at higher throughput and larger scale. We applied it to a 1.2 cm P1 mouse section and UMAP learns the manifold over iterations.
1
3
11
Kamala's mother immigrated from India to pursue a PhD & stayed to work as a cancer researcher Kamala's father immigrated from Jamaica to pursue a PhD & stayed to work as a professor Immigrant scientists contribute not only to science but to society at large -- for generations
1K
6K
47K
On the International Day of Women and Girls in Science, let’s help girls everywhere pursue careers in science, technology, engineering and math. Our world is better with their ideas and perspectives.
5K
12K
72K
We are happy to share our latest long-range, programmable mutagenesis toolbox - the Helicase-Assisted Continous Editing (HACE) system - to achieve target-specific mutagenesis of the endogenous genome. (1/11) https://t.co/boPlzlDBaE
biorxiv.org
A major challenge in human genomics is to decipher the context specific relationship of sequence to function. However, existing tools for locus specific hypermutation and evolution in the native...
5
47
207
It’s been a great year with the Chen lab!
As January wraps up the beginning of the new year, we took time to reflect on Chen Lab highlights from 2023…
0
0
8
As part of the @NIH #BICCN effort, Broad researchers used their spatial transcriptomic technology to create a map of a mammalian brain, revealing remarkable diversity in understudied regions and uncovering clues to cellular function and roles in disease. https://t.co/CvUaiQcyIb
0
9
24
Slide-tags adds spatial coordinates to single-cell sequencing measurements! Please explore the paper, published online today in @Nature! https://t.co/HIyNuhJyR4
nature.com
Nature - Slide-tags enables multiomic sequencing of single cells and their localization within tissues.
7
26
137