Hattie Chung
@hattaca
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asst prof @YaleMed | studying cell circuits and tissue homeostasis in the ovary & cardiovascular disease | omics & machine learning | @hattaca.bsky.social
New Haven, CT
Joined March 2009
When and how do different tissue physical structures deteriorate during aging (structural aging)? What molecular changes occur in tissues during periods of major changes? Are there tissue-specific periods of accelerated structural aging? Which organs age early vs. late? Is
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🚨 New preprints from our lab! First, we introduce Cryo-mtscATAC-seq, led by Maren (@ms-maren.bsky.social), enabling high-throughput clonal tracing from frozen human samples by isolating nuclei with their mitochondria (“CryoCells”). 👉
biorxiv.org
High-throughput clonal tracing of primary human samples relies on naturally occurring barcodes, such as somatic mitochondrial DNA (mtDNA) mutations detected via single-cell ATAC-seq (mtscATAC-seq)....
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Building on the legacy of many, I'm incredibly excited that we have successfully translated our polygenic risk scores into a validated clinical assay @MassGenBrigham @broadinstitute, orderable by any clinician in the US today. 🧬To order: https://t.co/lmPHq57sKQ 🧬Announcement:
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Check out this cool work led by @nithyabhasker @mweber_PU where we develop Contrastive Poincaré Maps (CPM), a self-supervised hyperbolic encoder for scRNA-seq that preserves hierarchies & scales efficiently!
Single-cell data can reveal hierarchical patterns in organismic development but popular embedding approaches often distort them. We introduce Contrastive Poincaré Maps, a self-supervised hyperbolic encoder that preserves hierarchies, scales efficiently, and uncovers developmental
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Single-cell data can reveal hierarchical patterns in organismic development but popular embedding approaches often distort them. We introduce Contrastive Poincaré Maps, a self-supervised hyperbolic encoder that preserves hierarchies, scales efficiently, and uncovers developmental
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@jengreitz & I are looking to hire a computational biologist/biostatistician with project management expertise to collaborate with our teams to map the regulatory code of the human genome and discover genetic mechanisms of disease. Details below https://t.co/lsyqN9kFHS Plz RT
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Save the Date: The 2nd Yale Center for Research on Aging (Y-Age) Symposium is set for Monday, October 13 at the Anlyan Center at @YaleMed. Join us for a day-long discussion on human longevity, geroscience, and the biology of #aging. @YalePathology. https://t.co/EbPTo6Crgz
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What do you do when grants are cancelled, faculty searches are frozen, and the ability to do the science you believe in is slipping out of reach? I wrote an essay. On efforts to solve aging with reprogramming, the primacy of the epigenome, and the path to rewriting our future:
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What if LLMs could “read” & “write” biology? 🤔 Introducing C2S‑Scale—a @Yale + @GoogleAI @GoogleDeepMind collab: we scaled LLMs (up to 27 B!) to analyze & generate single‑cell insights by turning transcriptomes into text 🧬➡️📝 🔗 Blog: https://t.co/6jGBDBhP4z 🔗 Preprint:
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"Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet" Our study highlighted in @Nature News https://t.co/p7Pt51a9Pi
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It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis
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Promoting healthy aging in women. Prolonging ovarian life. Slowing the onset of menopause. A feature @nature
https://t.co/UX8OIUvlv5 open-access And this week's editorial https://t.co/HvWKwoMvY0
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The ovary might be the most remarkable example of tissue organization in the human body - dynamically remodeling itself hundreds of times across reproductive life. Let's learn how it's organized and how aging disrupts this orchestra. Megathread!🦣🧵
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Grateful to have been included in this incredible project, alongside such an amazing team!
Excited to share our lab's first preprint: we used spatial transcriptomics to dissect how aging disrupts the cycling ovary! 🧵 This was an incredible team effort w/ @jenngarrison @Tammyinlab @davidsebfischer AlisonKochersberger @RuthRaichur @sophiamszady
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What cellular & multicellular changes underpin aging of ovaries? We used spatial transcriptomics to study this process in mice, capturing dynamic changes in cells, follicles, and tissue across the estrous cycle. Read about the age-related changes in these dynamics we discovered!
Excited to share our lab's first preprint: we used spatial transcriptomics to dissect how aging disrupts the cycling ovary! 🧵 This was an incredible team effort w/ @jenngarrison @Tammyinlab @davidsebfischer AlisonKochersberger @RuthRaichur @sophiamszady
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2nd law for the inevitable win
Read the preprint here:
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11/ Interested in tissue dynamics, technology development, and computation? We are recruiting motivated experimental and/or computational postdocs! We have much brewing spanning ovarian aging, metabolic health, immune dynamics, and therapeutics🧪 https://t.co/JHWIi1DeSU
hattiechunglab.bio
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