Roopali Khanna
@RoopsieK
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Integrated Ph.D. student @SamratLabMohali @IiserMohali
Joined April 2021
Happy to share our latest paper published in PCCP (Physical Chemistry Chemical Physics) @PCCP @RoySocChem. Congratulations to my PhD student, @Jaspreet_Tiet @TIETofficial. Thanks to ANRF-POWER and MoE-STARS for supporting our research. Here's the link: https://t.co/MJVkfGH8uM
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Happy to share our just published @NatureComms article from @IiserMohali @DCS_IISERMOHALI Thanks to @ANRFIndia for funding. Hard work done by @Rishiram7777 Niranjani @NandhaEttikkan #ReactionDiffusion based system https://t.co/ye3v4cgpDS
nature.com
Nature Communications - Achieving spatiotemporal gating of signals is desirable for mimicking of biological processes, but is challenging to achieve in synthetic systems. Here, the authors report a...
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I’m thrilled to share that our latest work, led by PhD scholar @_Das_Priyanka, is published in @embojournal! Using a bacterial mutant library screen, we identified that bacterial-induced ROS extends C. elegans lifespan by disrupting its iron homeostasis.
embopress.org
imageimageGut microbes are key modulators of host lifespan, yet the underlying mechanisms remain poorly understood. This study shows that gut microbes, which induce oxidative stress in Caenorhabditis...
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Phase separation to buffer growth-mediated dilution in synthetic circuits: Cell
cell.com
Phase separation stabilizes synthetic gene circuits and boosts production under dynamic growth conditions. By locally concentrating transcription factors at promoters, it protects gene expression...
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Excited to share Deeptodeep’s PhD work https://t.co/QX3uNc6F5o Congrats on first & co-corr. authorship! We uncover redox switch as a novel mode of activation of E. coli envelope protease DegP that enables it to integrate various stress cues @caughtnd_act @DBS_IISERM @IiserMohali
biorxiv.org
DegP, a bifunctional chaperone-protease central to maintaining envelope proteostasis in Gram-negative bacteria, serves as a paradigm for understanding protein quality control mechanisms. Decades of...
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Yesterday, we had an amazing dinner with the members of my lab and @MilyBhLab at our apartment. It was fun (I was made to play guitar🎸and sing old songs😃). This was a homecoming for my former student @Harshita3110 & a send-off for @aroralisha20, who is leaving for her postdoc.
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Nuclear Pore Complexes (NPCs) are the gateways to the nucleus, but how can they be both rapid and picky, even for very large cargoes? To answer this question, we built the most detailed data-driven model to date of transport through NPCs. https://t.co/DWh3XMWZPL
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Hijacking a bacterial ABC transporter for genetic code expansion:
nature.com
Nature - Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins...
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Happy to share final version of our work in @eLife! We reveal how inhibiting the UFD-1-NPL-4 complex in C. elegans triggers an aberrant immune response, reducing pathogen load but ultimately compromising host survival. @aaballay1 @RajneeshRao16 @DBS_IISERM
elifesciences.org
Inhibition of the UFD-1-NPL-4 complex activates immune responses in Caenorhabditis elegans that reduce gut pathogen load but simultaneously compromise host survival.
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Happy to share our community note published in Nature Communications. In this 14-page article (34 authors from 9 countries), we discuss current practices in biomolecular phase separation and hope it will be useful to the biomolecular condensate community. https://t.co/UgwnvPpOk2
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Thrilled to share this new Adv. Sci. paper by @dianatanasedt with Dino Osmanovic @rogerrubio Layla Malouf and Elisa Franco. We demonstrate a modular approach to program internal phase separation in DNA condensates 1/n https://t.co/7lraRg9Mnh
advanced.onlinelibrary.wiley.com
The modular, programmable system of DNA nanostructures developed provides programmatic control over multiphase condensate behavior, enabling mapping onto a predictive Flory-Huggins model. This...
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Building a human ear on the back of the mouse, 3D printed bone regeneration scaffolds, and human liver-on-a-chip, were warm-ups for building a human endometrium in lab. Want a difficult problem that is the root of women's health? Study menstruation. 🧵 https://t.co/UTTAFR9zZn
news.mit.edu
The Fairbairn Menstruation Science Fund will advance groundbreaking research at MIT on the function of the human uterus and its impact on sex-based differences in human immunology that contribute to...
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Another paper accepted from the lab in the Proceedings of the Indian National Science Academy. Our first contribution to an Indian journal. @_Harshita3008 Harshita started this as a side project that turned into a nice story!
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Huge congratulations to @A_Emelianova, Pablo and Daniel on their paper on small-molecule partitioning into condensates now published in @JACS_Au and selected as ACS Editor’s Choice!! https://t.co/4wCVndaEu8
pubs.acs.org
Predicting small-molecule partitioning into biomolecular condensates is the key to developing drugs that selectively target aberrant condensates. However, the molecular mechanisms underlying small-...
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By flipping an evolutionarily disabled genetic switch involved in Vitamin A metabolism, researchers in Science have enabled ear tissue regeneration in mice. Learn more: https://t.co/zxLoqAzgLc
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Our latest publication: Probing Protease‐Mediated Decrease of Albumin‐Catalyzed Kemp Elimination: Potential Application as Biosensors @ChemCatChem congrats @Shikha3342 @priya_bhalwal @ShandilyaEkta from @DCS_IISERMOHALI. Thanks @DBTIndia for funding.
chemistry-europe.onlinelibrary.wiley.com
Protease-specific suppression of the albumin-catalyzed Kemp elimination (KE) reaction is reported in aqueous buffer, urine, and blood serum. Specific chymotrypsin-mediated decrease in KE reactivity...
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A feature in @Nature shows how tardigrades exist in a sweet spot for researchers and why neuroscientists are working to make them a model organism for studying how neural circuits work.
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RNA codon expansion via programmable pseudouridine editing and decoding:
nature.com
Nature - An RNA codon-expansion strategy enables incorporation of non-canonical amino acids into proteins of interest orthogonally to existing methods by inserting pseudouridine codons into...
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We're one, but we're not the same We get to carry each other, carry each other – U2
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Happy to share our recent paper in RSC Advances @RoySocChem from our collaborative effort with Dr. Maity @maity_banibrata @TIETofficial Congratulations to our PhD student Mandeep Kaur @MandeepTiet. Read our paper: https://t.co/WsW1CZoyfh
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