Rachna Chaba
@ChabaRachna
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Professor, DBT Wellcome Trust Senior Fellow, Bacterial Genetics and Physiology Lab at IISER Mohali
IISER Mohali
Joined March 2018
3/ The thiol form of DegP is its protease-active form, which, besides clearing aberrant proteins, activates the Cpx envelope stress response. The diversity of molecular players that can impact the redox status of DegP positions it as a general protease.
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2/ We show that different redox stressors bring DegP in its thiol form via two distinct mechanisms that operate in a temporal & stress-specific manner- compromised disulfide bond forming machinery fails to oxidize DegP & misfolded substrates engage with DegP allosterically.
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Excited to share Deeptodeep’s PhD work https://t.co/QX3uNc6F5o Congrats on first & co-corr. authorship! We uncover redox switch as a novel mode of activation of E. coli envelope protease DegP that enables it to integrate various stress cues @caughtnd_act @DBS_IISERM @IiserMohali
biorxiv.org
DegP, a bifunctional chaperone-protease central to maintaining envelope proteostasis in Gram-negative bacteria, serves as a paradigm for understanding protein quality control mechanisms. Decades of...
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Hearty congratulations Rhitoban and team! A proud moment for @DBS_IISERM @IiserMohali
Congratulations Rhitoban for bringing unprecedented joy and pride for IISER Mohali on the eve of its Foundation Day by publishing your work in “Science”. You are the Hero of this Foundation Day. 👍👍👍@EduMinOfIndia @IndiaDST @dpradhanbjp
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Thank you @India_Alliance for the opportunity to share work from our group. It was a great meeting- excellent science and wonderful community! @IiserMohali @DBS_IISERM
@DBTIndia @wellcometrust @rajesh_gokhale @jarottingen @SunilLaxman @TPucadyil @Ludwig_Cancer @UCSanDiego @IGIBSocial @IISERPune @DBT_inStem @anaturalist @NIMHANS_BLR @OffCMCVellore @iiscbangalore @HFSP @drshirshendum @katrinalawson @Madhuridutta15 @OUCRUID @PenmatsaLab @NuaAstya The second session of the day was chaired by Dr. Robert Read (University of Southampton). Talks by Dr. Kamlesh Pawar, Dr. Abhishek Majumdar, Dr. Rachna Chaba & Dr. Pushkar Sharma spanned small RNAs, molecular machines, bacterial stress, and malaria parasite regulation.
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Thank you Gaurav for the invitation. It was wonderful visiting IITH, interacting with faculty and students. Also, finally met you after 2 yrs of our first conversation.
It was a pleasure to host @ChabaRachna at @BTIITH, two years after our Ist collaboration chat on @X! Her talk on sugar acid metabolism in enteric bacteria was a hit. My lab folks also pitched their projects for her feedback. Super excited about the ongoing collaborative ideas!!
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Thank you DBT/Wellcome Trust India Alliance for making a difference in my research career 😊!
Highlighting #DBTIndiaAllianceSuccessStories—noteworthy research and practical innovations powered by @DBTIndia and @India_Alliance, creating real-world impact. Meet Dr. Rachna Chaba, Professor in the Department of Biological Sciences at IISER, Mohali. Her work uncovers how E.
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Congratulations @swatisingh2511 for nicely explaining your recently published work in this interview.
#authorinterview Dr. Swati Singh @swatisingh2511 working with Prof Rachna Chaba @ChabaRachna at IISER Mohali @IiserMohali talks about her work on "Decoding the impact of genetic variations in DgoR on D-galactonate metabolism" @JBacteriology @ASMicrobiology
https://t.co/d64iaWSGcZ
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ThankU for the invitation for a talk at EMBO-EMBL Microbiology Symposium. Excellent science & wonderful community. Meeting my postdoc mentor, Carol & friends was quite a highlight. Wonderful memories! @FredBarras @LiselotDW @MichaelDeghelt @TypasLab @iSamirgiri #Alex #Emmanuelle
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@SuyalShradha @Apps_Sarkar @aroralisha20 @panchal969 @Megha65462884 @SnehalWaghmare_ @swatisingh2511 @Chauhan24Gunjan @AzeezTehseen__ @rav_budha @Shraddhagandhi5 @M_S_Dharmawath @PremrajSha77387 Kusum Lata, Ruchika Choudhary
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2/2 Congrats 1st author @swatisingh2511 & all co-authors @RAJESHM56735381 @kakkar96 @shivam_singla97 Thanks @SharmaG30 for bioinformatics work & #Monika Sharma for simulations Thanks @DBTIndia @India_Alliance STARS @EduMinOfIndia @serbonline @IiserMohali for support @DBS_IISERM
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1/2 Elated to share our work in @JBacteriology @ASMicrobiology Using genetics, biochemical, bioinformatics & simulation studies, we investigated functional consequences of variations in a GntR/FadR family regulator of sugar acid metabolism in E. coli https://t.co/vXtrkWOIs6
journals.asm.org
Sugar acids are used as carbon sources by enteric bacteria, both commensals and pathogens, with numerous studies highlighting their importance in host-bacterial interactions. Here, taking Escherichia...
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2/2 Congratulations to Megha @Megha65462884 & Deeptodeep @caughtnd_act for putting together this excellent review. @DBS_IISERM
@IiserMohali
@India_Alliance
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1/2 Happy to share our COMICR review on 'Long-chain fatty acids as nutrients during infection in Gram -ve human pathogens & it’s association with stress & stress response mechanisms
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We have 2-3 Ph.D. positions in https://t.co/izg7N6O9BD
@IISERMohali. Students interested in understanding how bacteria sense & adapt to nutrient availability & stress conditions, please apply. Deadline: April 10
iisermohali.ac.in
Applications are invited from prospective candidates for admission to the PhD program at IISER Mohali in Biological Sciences, Chemical Sciences, Physical S...
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Looking forward to this wonderful conference!
⏳ The #EESMicrobiology abstract submission deadline is fast approaching ⏳ 🦠🔬 Don't miss the chance to present your research to top scientists from around the world working with bacteria and new technologies! Submit your abstract by 1 April 👉 https://t.co/I7NmOHZC1C This
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Today on #WorldTBDay Our colleague Professor Rachna Chaba will be participating in a conversation initiated by @India_Alliance. Stay tuned.
Our fellow for the day: Why @ChabaRachna looks into TB? Fats are a rich source of energy for bacteria. However, work in her laboratory over a decade in the model bacterium E. coli showed that feasting on fats can actually harm bacteria until they use certain defense mechanisms.
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Looking forward to the event!
Why does TB treatment take so long? Why is drug resistance prevalent? Why are some communities more vulnerable? 🤔 This World TB Day, join us for an X chat with IA fellows tackling these crucial 'whys' at the molecular level this Monday, 11 AM - 2 PM #WorldTBday
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🎉🎉 Another best poster award from @ChabaRachna lab. Congratulations 🎉🥳 Deeptodeep @caughtnd_act for the best Poster award at Transcription Assembly Meeting 2025 @bose_institute. @DBS_IISERM @IiserMohali
Attended the Transcription Assembly Meeting 2025 @bose_institute-thankful to @ChabaRachna for giving the opportunity to participate. The meeting was an ensemble of stars from the field of transcription & beyond! Also elated to win the Best Poster Presentation award! @DBS_IISERM
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