First first author is out! Had a blast figuring out how cancer lines use fructose as a growth substrate with fon this while working in the @MarcusDGon lab

Where do cancers start? In the liver, not all cells are the same. The liver is divided into 3 “zones,” and each specializes in different metabolic tasks. We show in @Science that where a mutation occurs in a liver lobule can determine a cell’s fate. https://t.co/3YTc77gZcd (1/9)

Good news: CRI's @MishraLab & @Zhu_Lab have been selected to develop in vivo genetic screens to identify new regulators of liver #trauma. It's another example of CRI's #relentlessdiscovery toward the treatments of tomorrow. @UT_TRC4

🦖 Something HUGE just hatched. Plasmidsaurus now offers RNA sequencing for gene expression analysis with: • As fast as 3 day turnaround • $50/sample for academia, $80 for industry • Up to ~10M unique transcript 3’ end reads per sample • Interactive results that let you

New preprint! We know cancer cells with somatic mutations are selected to evade the immune system. With @imartincorena Peter Campbell @ZJL1435957 @QuotientTx, we asked if immune cells with somatic mutations are also selected to fight cancer. https://t.co/2CWjTgZ3nY 1/5

Super cool preprint by @Zhu_Lab @CRI_UTSW Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity https://t.co/qKY8JL0VTJ Are there naturally occurring somatic mutations in lymphocytes that augment anti-tumor T cell function?

We're growing! Our newest Investigator @Henry_de_belly will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ https://t.co/lHKW4u05xP and 📌apply to research in his lab https://t.co/fX7rO4zlwS #relentlessdiscovery

Why does the naked mole rat have the longest lifespan and healthspan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing

In this Editor's Choice, Maggiore, Zhu @Zhu_Lab & co reveal the high clinical potential of GalNAc-siRNA-based strategies for preventing hepatocellular carcinoma development in high-risk individuals, particularly through targeting ANLN. https://t.co/2tVIB0ekKl #HCC #cancer

🎉 JUST ANNOUNCED: @Zhu_Lab named project co-leader for @UTSWMedCenter liver cancer SPORE. His project will study how to prevent hepatocellular carcinoma — which accounts for >85% of liver cancer cases across the nation. Read more ⬇️ https://t.co/5r04lcPNxt #relentlessdiscovery

Researchers with Dr. Hao Zhu and Gregory Mannino detect TBX3 somatic mutations in patients with metabolic dysfunction-associated steatotic liver disease (#MASLD). Take a closer look at their findings. 🔎 https://t.co/C4h5sMPxtX

wow. stop what you're doing and read this paper. 🤯 https://t.co/zyv2IXr21q

Congratulations to Eric Olson, Ph.D., founding Chair and Professor of Molecular Biology @UTSWMedCenter, on being selected to receive the Louisa Gross Horwitz Prize for groundbreaking research into Duchenne muscular dystrophy.

In vivo follow-up on MFSD12 and an embryonic lethal phenotype that we found was recoverable with cysteamine treatment. with @DMSabatini and @FisherLabMGH Out today! https://t.co/UdxoZ4Z76G

Thrilled and deeply honored to be named a 2025 Pew Biomedical Scholar! Huge congrats to my friend and colleague @CRI_UTSW @JaviGBermudez , who’s also joining the Pew family as a Pew-Stewart Scholar. CRI is on fire—let’s go make some bold, groundbreaking science happen! 🔥🧪✨

We report the first physiological benefit of ascorbate/vitamin C deficiency: protection from a major human parasite which needs it for development. We propose that this can explain why ascorbate became a vitamin (its synthesis was lost) in humans and many other animals.

MASLD has become the most common chronic liver disease worldwide. Giovanni Targher, MD, Luca Valenti, MD (@lucavalenti75), and Christopher D. Byrne, MB, ChB, review the features of the disease as well as pharmacotherapies targeting the associated liver and

Congrats! 👏👏👏 Two CRI scientists named 2025 Pew-Stewart & Pew Scholars — @JaviGBermudez & @HijaiShin — to advance cancer, biomedical research. Read more about their #relentlessdiscovery ⬇️ https://t.co/MAFSU4zUqs @pewtrusts

A new paper about siRNAs for liver cancer prevention--It should be done! Chemoprevention for hepatocellular carcinoma using GalNAc-siRNAs

Our paper on discovering a new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein found in > 20 yr) is out in @NatureCellBio! Wonderful, equal collab with Tony Rodrigues, @dwendscheck, Jorge Azevedo, @warscheidlab https://t.co/8TqgxcNqis

Our #SomaticGenomics platform follows a novel approach to uncovering links between genes and disease. This reveals a path to develop transformative therapeutics with intrinsically validated targets. Discover how our platform works: https://t.co/jZVBHcnI05