Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @ImmunityCP! ➡️

@the_hindu Many thanks to Dr. Deepak Nair @iiscbangalore for his thoughtful comments on the role of lipid metabolism in Alzheimer’s disease and its relevance to our findings.

Excited to share @the_hindu coverage of our research: “Immune cells’ fat blocks brain’s ability to clean Alzheimer’s plaques” -- now out in print and online! Grateful to Manjeera Gowravaram for the thoughtful and clear storytelling.

Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4

RT @Nithin0dha: Here's something awesome 😍. Reshma, Lakshmi, Kirat, and Yamini are four young 8th- and 9th-standard girls from rural and so….

So impressed by the researchers and students who were eager to discuss science and research. This is a wonderful initiative led by Dr. HS Nagaraj, a visionary leader and an inspiring individual. Support @PrayogaIER!

Had a wonderful visit to @PrayogaIER, a non-profit organization focused on experiential learning and research-based education for school students across Karnataka (65 schools and 6000+ students so far!) . Also, a beautiful, serene campus!. Learn more 👉🏽

RT @kimberleydbruce: Important work! Reducing microglia lipids droplets improve function! But where will these intermediates be shunted no….

RT @DrawImpacts: A real pleasure collaborating with you and the team, @DavalosLab @pryprk — congratulations on the publication! Looking f….

Bummed we didn’t get the cover, but absolutely thrilled that Emma Videl (@DrawImpacts) brought our microglia superhero vision to life in the most fantastic way! 🦸‍♀️🧠💥 #SciArt #Alzheimers #Microglia #Immunity‍ #notthecover .

Meet M, our microglia superwoman 🦸‍♀️! After chugging the magical 'DGAT2-Stop!' kool-aid 💊, she breaks free from her lipid droplet shackles💪. Supercharged, she lifts the amyloid beams 🧱 trapping neurons and saves the brain city🏙️! Our cover submission @ImmunityCP. #notthecover

RT @DavalosLab: Microglia: Super-heroine that had a DGAT2-blocking beverage (cans) so she could break the chains from lipid droplets holdin….

RT @EviPaouri: Super proud to have been part of this work between the @chopralab and the @DavalosLab that is now published @ImmunityCP !!!….

RT @chopralab: We identified a critical mechanism linking "fat" in microglia to impaired amyloid-beta (Aβ) clearance in Alzheimer’s disease….

RT @OlegButovsky: @DavalosLab @ImmunityCP Dimitrios and colleagues, very interesting findings, would be interesting to see translational di….

RT @R_A_Vishwakarma: DGAT1 for metabolic syndrome (obesity) and DGAT2 for Alzheimer’s: Interesting isoform driven function amenable to sele….

🙌🏼 This work represents a remarkable collaboration btw the @chopralab (@LifeAtPurdue) + @DavalosLab (@ClevelandClinic), driven by the outstanding efforts of all authors — including co-1st author Palak Manchanda, Evi Paouri, & others — who brought it to the finish line.

🟡 Lipid-laden, DGAT2-high microglia exhibit impaired Aβ phagocytosis and neuronal damage. 🟡 DGAT2 degradation restores Aβ uptake and reduces amyloid plaques and dystrophic neurons.

We show that - . 🟡 Aβ drives microglial lipid droplet buildup via DGAT2-mediated conversion of free fatty acids to triacylglycerols . 🟡 Microglial lipid droplets and DGAT2 are elevated in AD mouse models and human brains.

RT @LukensJohnR: Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @ImmunityCP….