latest from the lab --> how we used whole genome passenger somatic mutation patterns 🧬 to trace the origins of never-smoker lung adenocarcinoma (LUAD) to cells of the proximal lung 🫁 @NatureGenet https://t.co/jqNdVSdZ9z 1/🧵

Parabricks, a genomics startup with the goal to GPU-accelerate NGS analysis, was acquired by @NVIDIA in 2019. The Parabricks team has recently published their body of work showing GPU-accelerated, universal analysis that supports a wide range of sequencing platforms - including

Thrilled to share our paper now out in @Nature that correlates inactivating PPP2R1A somatic mutations with improved survival for patients with cancer receiving immunotherapy, with exciting prelim mechanistic insights! @AmirJazaeri @IamLinghua @Yibo_Dai

1/ 🧵Check out our new study in @NatureGenet, which examines how precancerous conditions (MGUS/SMM) evolve into Multiple Myeloma, and offers new computational methods to predict progression risk and model cancer evolution. https://t.co/IHnN87QKTk

Check out new work from @NVIDIAHealth Genomics, @genentech, transcriptome-guided genomic alignment with transformer-based splice junction scoring, delivering SOTA in splice junction detection, indel identification, and resolving complex splicing patterns

Tumor-Infiltrating Clonal Hematopoiesis https://t.co/iD3U6CrrUG

What a way to close out this year's APS March Meeting! #APSSummit25 #Aurora #Quantum

We are hiring 🎺🎺🎺! As part of our immuno-oncology transformation @MSKCancerCenter we are building the Computational Immuno-Oncology Shared Resource. CIOSR is a key pillar supporting expanded immune monitoring & broad IO efforts. We have two open positions: bioinformatics

One way to trace AI over the last year is GPQA Diamond. This is a Google-proof question set that experts get 81% right in their fields & highly skilled non-experts with 30 minutes per question and Google access get 22%. GPT-4 got 37% at the start of 2024. o1 got 78%. o3 is 87.7%

Most exciting event of spring 2025! Please come join us!

Cool scientists!

Nobel for the not-junk-DNA! microRNA FTW! 😄😄😄

🚨 New preprint alert! We performed scRNA-seq & scTCR meta-analysis on cancer patients treated with ICIs, revealing key T cell signatures linked to therapeutic response, with insights into clonal replacement vs reinvigoration! #scRNAseq #Immunotherapy https://t.co/d35nY6dfIf

Neoantigen immunogenicity landscapes and evolution of tumor ecosystems during immunotherapy with nivolumab @NatureMedicine @GeneCollector @xrtGenomics https://t.co/Taonn58ftH

אמא כותבת: איבדתי את הבן שלי שנהרג בעת שנלחם בגבורה בקרב בקיבוץ בארי. קצין צעיר רק בן 20. אני רק מבקשת שלא תשכחו את הילד הגיבור שלי!! אשמח שתשתפו לזכרו של הבן שלי יונתן גוטין גיבור ישראל!!

Applications are open for Max Planck Research Group Leaders! this is an amazing opportunity to build an independent research group that comes with 2.7 MEuro support over 6 years. If you're interested in being hosted @mpi_astro, please contact me!

With @rheinbay_lab and additional Broad collaborators, we are excited to enter into this partnership with @Inocras to analyze whole genomes for the benefit of cancer research and cancer patients 🧬! @GenomeDoctor @BroadInstitute @MGHCancerCenter

BRCA1 and friends 30 years on -William D. Foulkes https://t.co/vVb8XqJNis In this beautiful article in @NatureRevGenet , @WillDFoulkes takes us back in time to the moment BRCA1 discovery was revealed to the world by Myriad Genetics at the ASHG 1994 ( https://t.co/UnAAYweKGk).

An artificial intelligence-powered method for detecting tumor DNA in blood has shown unprecedented sensitivity in predicting cancer recurrence, says a team led by Dr. Dan Landau (@landau_lab) and researchers at @nygenome and @MSKCancerCenter. https://t.co/2ZCZMnsnBG

thank you to all who stopped by my poster & helpful comments to improve the generative model! @MSKCancerCenter Tumor-Immune Systems Biology Symposium on 05-22-2024