
Vega Shah
@dr_alphalyrae
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AI for Life Sciences & Healthcare @NVIDIA | trained as a scientist from @JGI, @UW, @UCBerkeley | building global community @TechBi0 | views are all mine
San Francisco Bay Area
Joined December 2013
Twenty Years In Early Stage Biotech VC (Part 2): People Continuing in the trifecta of anniversary blogs, here are a few observations on people, talent and teams: · The power of luck! · Life is short… live by the NAR (No Asshole Rule) · By the time you know you need a
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Turns out our Series A grew larger. All the more reason @LilaSciences is an exciting new frontier AI lab, and one of the top places in the world to work on on open-ended discovery.
We’ve closed our Series A. With $550M total raised since launch, we’re ready to scale. 🚀Learn how our Series A is fueling our next chapter:
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Genomics team keeps cooking!
How fast is fast? ⚡ Over 14x faster runtimes with pangenome-aware DeepVariant 1.9 + Giraffe on four NVIDIA RTX PRO 6000 GPUs vs CPUs. Plus, DeepSomatic long read and WES support, quantMode GeneCounts for STAR, and Mutectcaller mitochondrial mode. What could this mean for your
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New🎙️What can you do for a mom facing an unexpected pregnancy? Gina Tomes has dedicated more than three decades to walking alongside women and families facing unexpected pregnancies and championing life. After the fall of Roe v. Wade, Gina recognized the urgent need to expand the
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I'm looking for the "Anduril" of Bio. Anyone know any Bio-Defense startups?
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In more pharma-AI bio partnership news: Takeda has signed a second deal with Nabla Bio @SurgeBiswas described Nabla's latest AI model, JAM, like an "autocomplete for molecules." https://t.co/av4eTs2Bv2
endpoints.news
Takeda expands AI partnership with Nabla Bio, paying upfront double-digit millions plus potential $1B+ in milestones to advance protein design and drug development efforts
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Clinical trials are a vital step in the development of new medicines. Unfortunately, we're not very good at enrolling patients in them. We run more clinical trials than ever, yet the vast majority of studies fail to hit their enrollment deadlines. It’s a crisis that slows
Excited to announce our $4.3M Seed Round, led by Andreessen Horowitz with participation from Alt Capital (Jack Altman) and First Harmonic (Ali Rowghani) and the public launch of Alleviate Health. Alleviate empowers research sites’ best recruiters to connect with more
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🔥 Don’t miss the fireside chat at our @PunchbowlNews event on Oct. 20! @AmericaInvests Council’s Will Dunham will join Anna Palmer to discuss how private capital supports jobs & small businesses.
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when two awesome companies join forces
🧬 We’re teaming up with @NVIDIAHealth to bring #BioNeMo models directly into #BenchlingAI. Scientists will be able to access leading models like OpenFold2 for protein structure prediction — right inside their workflows. https://t.co/WYBrVMEgN9
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@dr_alphalyrae Anita is building an awesome company to do this
getpeer.ai
The agentic AI platform for life sciences—Peer AI accelerates regulatory & clinical documentation across phases, combining speed, quality & compliance.
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gettin nerdy, having fun always ✌️🧬
I wonder what @dr_alphalyrae will be up to when turning 45 🤔🤔lololol
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The answer is skin cells. Skin cells! That seems really odd, but lots of cells share lots of components and processes that are used in different ways in different cell types. And not-fun fact: psychotic symptoms are associated with skin abnormalities.
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15 years in the making, we confirmed that mitochondria -the powerhouse of the cell- have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery...🧵
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Starting a software co is like building a plane & trying to get it to lift off before you run out of runway Starting a biotech co is like trying to solve an escape room before time runs out For software co, getting the plane off the ground requires primarily ppl who can work
Keith Rabois: “I tell founders not to worry about runway. Worry about lift.” “If you think about lift in a plane context, a company is only valuable if you achieve lift. Runway is a tactic for achieving lift, and you may need to extend the runway so that you have more time to
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i am still of the opinion that solving the boring operational problems in biopharma r&d, like slowness in regulatory documentation and process development is the most effective way to derive value from AI in the short term
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Bacterially grown living materials with resistant and on-demand functionality | Science Advances https://t.co/vTERXjCsfW
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Check out our recent work on how researchers can collaboratively train AI models to predict protein properties such as subcellular location, without moving sensitive data across institutions, using @nvidia FLARE and @NVIDIAHealth BioNeMo Framework
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The proteins in our blood as fingerprints for 59 diseases and health @ScienceMagazine
https://t.co/02MgtnDqp6
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Yeah, I am as excited as the next guy about creating an “AI scientist”, but I know all too well that for decades intelligence has not been the main bottleneck for creating better and more advanced scientific breakthroughs. We’ve been churning out more science PhDs than we knew
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CRISPR came from yogurt bacteria. GLP-1s came from Gila monster venom. Taq polymerase came from hot spring bacteria. As much as we like to think that progress in biotech is driven by human design, our biggest breakthroughs over the years have all originated from nature.
The ocean is one of the last great frontiers of biology. More than 90% of all marine life (an estimated 2M species) have not been discovered. Also, only ~10% of the seafloor has been mapped at 100m resolution, "as compared to 100% of...Mars and Venus." We should sequence
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TusoAI: Agentic Optimization for Scientific Methods
arxiv.org
Scientific discovery is often slowed by the manual development of computational tools needed to analyze complex experimental data. Building such tools is costly and time-consuming because...
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