Olga ROSSPOPOFF
@ORSPF
Followers
203
Following
489
Media
7
Statuses
100
Postdoc @Trono_Lab & former PhD student in @Crougeulle Lab! interested in genome evolution 🤘🏼
Switzerland
Joined February 2012
I’m excited to share a new preprint from some of my work in the lab of @todd_macfarlan ! 😄 We dived into young KZFP gene clusters in different mouse strains and species to uncover mechanisms that facilitated their evolution and diversification in mice
Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice https://t.co/oQdqTwYW6R
#biorxiv_genetic
1
3
9
Finally out! We present EXTRA-seq, a new EXTended Reporter Assay to quantify endogenous enhancer-promoter communication at kb scale! https://t.co/FCZccqJQSt A 🧵about what it can do:
biorxiv.org
Precise control of gene expression is essential for cellular function, but the mechanisms by which enhancers communicate with promoters to coordinate this process are not fully understood. While...
5
24
107
Find out how genome loci are anchored to the nucleolus! Exciting preprint @Trono_Lab shows that ZNF274 competes with CTCF to keep H3K9me3 silenced genome at the nucleolus periphery, fine-tuning cell-specific gene expression. preLight: @Silviacamoeira ⬇️ https://t.co/e5ozAKW0oX
prelights.biologists.com
Find out how genome loci are anchored to the nucleolus! Exciting new study from @Trono_Lab shows that ZNF274 competes with CTCF to keep H3K9me3 silenced genome at the nucleolus periphery, fine-tuning...
1
9
28
Le Dr Claire Rougeulle, @CRougeulle, est nommée directrice du Centre de recherche de l’@institut_curie. Sa nomination le 3 juillet 2024 par le Directoire de l'Institut Curie, marque le début d'un mandat de 5 ans. ➡️ https://t.co/Ks7rZNqz7y
6
22
108
Happy to share the latest publication from the lab: XIST dampens X chromosome activity in a SPEN-dependent manner during early human development https://t.co/aSeOR7HhqV Congrats to @CharbelFeghaly @JeffOui94 @manucazottes @GribnauLab, David lab @ParisEpigenetix
pubmed.ncbi.nlm.nih.gov
XIST (X-inactive specific transcript) long noncoding RNA (lncRNA) is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female...
7
24
64
Excited to share our effort to understand mechanisms underlying the potential for gastruloids self-organisation! #Gastruloids #InNumberWeTrust #EMT
https://t.co/cb6QQ7LIZ9 1/11
biorxiv.org
Gastruloids have recently emerged as an efficient four-dimensional model for studying some aspects of post-implantation embryonic patterning. They undergo gastrulation-like processes leading to the...
13
26
92
Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation #palmitoylation and generate more infectious #virions! @FS_Mesquita @AbramiLaurence
https://t.co/1vGgyz6uiW
nature.com
Nature Communications - The fusogenic activity of SARS-CoV-2 Spike depends on its post-translational lipid modification by host S-acyltransferases, predominantly ZDHHC20. Here, Mesquita and Abrami...
1
6
20
How does the segmentation clock instruct cells to form a somite boundary? Read our new pre-print “Clock driven waves of Tbx6 expression prefigure somite boundaries”, by @Olivier_Venzin and colleagues, to find out. https://t.co/23LwXR3aUT Summary thread below: 1/15
1
13
53
Check out our latest preprint: XIST dampens X chromosome activity in a SPEN-dependent manner during early human development
biorxiv.org
XIST long non-coding RNA is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female pre-implantation embryos without triggering...
7
27
97
Ten points for cool paper title https://t.co/xNOp6RaMZa
1
4
28
Check this out: #lncRNA genes may exert their function through distinct mechanisms in different species. Thanks @JeffOui94 @ORSPF @Huret_C and all for your efforts. Stimulating collaboration with @RuggGunnLab and @heard_lab
academic.oup.com
Abstract. X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main
7
31
99
SO HAPPY that this paper is finally out. Congrats to all involved (especially @ORSPF, @CRougeulle) for this career changing endeavour! After several attempts, I'm delighted that this has found a welcoming home in @NAR_Open (🙏 review process) #lncRNA 1/ https://t.co/3qW6TUjaUG
academic.oup.com
Abstract. X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main
1
11
55
Express delivery from the @jbloom_lab arrived today! Thank you very much @khdcrawford for sharing your plasmids for #SARSCoV2 neutralization assays from your recent @biorxivpreprint with us - we really appreciate it! https://t.co/VHeVuBmITs Let the pseudotyping begin...
0
4
21
Working from home has reached a whole new level! Steve Henikoff is superexcited running his experiments using the CUT&Tag@home setup (PC: Jorja Henikoff). If you want to set this up, here is the link to CUT&Tag@home protocol https://t.co/wxnsfc5fc2
15
152
786
1/3 We had this recent #bioRxiv preprint from @todd_macfarlan and @Trono_Lab at our first Zoom-JC: https://t.co/DzeJkgVVrE. Very interesting study! Highlights include: large-scale ChIP-seq analysis of young KRAB-ZFPs in mouse followed by megabase CRISPR-deletion of KZFP clusters.
3
3
9
Didier Trono, a professor at @EPFL_en ’s Laboratory of Virology and Genetics, answers some common questions about SARS CoV-2 and the disease it causes, #COVID19. https://t.co/v2bznGioKU
0
2
3
Day 1 of remote working due to #coronavirus. Well done @EPFL_en for taking the right measures and sending everyone to work from home - I hope other institutions across Europe do the same! Let's all work together and do our part to #FlattenTheCurve of #COVID19
0
1
10
The Trono Lab @epflSV finally joined Twitter! Follow us to keep up-to-date with our latest research on #transposons and #KZFPs in development, cancer and disease.
3
13
56
We are pleased to release an expanded CRISPR Targets track for the hg38 assembly, showing DNA sequences targetable by CRISPR RNA guides over the entire human genome. https://t.co/aSAARzJ42I
1
20
45
A #postdoc position is available in my lab to unravel the mystery of #Xchromosome inactivation in primates. If you are interested in #Epigenetics, #stemcells, #noncodingRNA, #evolution, please apply!! And please RT
0
67
47