VDG Lab @ EPFL
@VDGLab
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News from the Laboratory of Cell and Membrane Biology (Gisou van der Goot Lab) at EPFL in Lausanne, Switzerland.
Lausanne, Switzerland
Joined July 2019
Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation #palmitoylation and generate more infectious #virions! @FS_Mesquita @AbramiLaurence .
nature.com
Nature Communications - The fusogenic activity of SARS-CoV-2 Spike depends on its post-translational lipid modification by host S-acyltransferases, predominantly ZDHHC20. Here, Mesquita and Abrami...
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A fantastic collaborative effort! Congrats to all involved! @FS_Mesquita @AbramiLaurence @MaurineLinder10 @ShernazBamji @chembioBryan and Gisou van der Goot!.@NatRevMCB.
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Late publicity! Check our last review regarding the wonderful world of S-#acylation aka #Palmitoylation. A comprehensive overview of the field and our take on the interplay between this #lipid #PTM and #immunity #metabolism #cancer and #brain.
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RT @FEBSJournal: 💡Viewpoint💡.💫S-acylation: an orchestrator of the life cycle & function of membrane proteins💫.✍️By @FS_Mesquita, F. Gisou v….
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Big thanks to all our collaborators and everyone from the @VDGLab @Trono_Lab @ACCESS_Unige. Learn more about the details of how cell damage caused by #viruses #toxins or #colitis regulates protein #acylation #palmitoylation, check it out!
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RT @MUmairanwar1: Delighted to share our take on the only reversible lipid PTM--S-acylation as a major regulator of protein dynamics and fu….
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RT @JCellBiol: Review: S-acylation is one of the most frequent posttranslational modifications that regulates diverse cellular processes. @….
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A Great Team Effort! .@FS_Mesquita.@AbramiLaurence.@gvdgoot.@Trono_Lab.@ACCESS_Unige .We show that infection triggers a transcriptional change in the host acyl-transferase ZDHHC20 producing an uncharacterized Longer Version of ZDHHC20 a few hours after initial cellular infection.
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#SARS2 #Lipidation Chapter2. How #SARSCoV2 boosts Host #Palmitoylation to promote infectivity! #Infection shifts transcription of ZDHHC20 palmitoyltransferase to increase #Spike Palmitoylation and produce more infectious #virus Stay tuned for Chapter3.
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RT @Gio_Dangel0: Is there more than transcriptional programs to drive cell identity? Here with @GioeleLaManno we discuss the lipotype hypot….
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RT @cell_club: ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains .
cell.com
Anwar et al. show that organization of the plasma membrane into nanodomains, which are required for anthrax intoxication, depends on the transfer of cholesterol at sites where the endoplasmic...
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RT @Gio_Dangel0: This was really a nice journey … thank you @MUmairanwar1 , @oxyquips and @AbramiLaurence for taking us this far….
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RT @MUmairanwar1: Thanks to all involved, in particular @oxyquips @AbramiLaurence @gvdgoot @Gio_Dangel0. @VDGLab we have to celebrate. 2/2.
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RT @MUmairanwar1: How are membrane nanodomains formed? Delighted to share our preprint where we show that plasma membrane compartmentalizat….
biorxiv.org
To promote infections, pathogens exploit host cell machineries including structural elements of the plasma membrane. Studying these interactions and identifying involved molecular players is an ideal...
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Great team effort that characterizes the #viral #lipid composition and shows that host #lipidation is required for #SARS-CoV2 infectivity!.@Gio_Dangel0 @matteodp @labriataphd @Trono_Lab .@EnyaQing @FS_Mesquita @AbramiLaurence
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