Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation #palmitoylation and generate more infectious #virions! @FS_Mesquita @AbramiLaurence https://t.co/1vGgyz6uiW

A fantastic collaborative effort! Congrats to all involved! @FS_Mesquita @AbramiLaurence @MaurineLinder10 @ShernazBamji @chembioBryan and Gisou van der Goot! @NatRevMCB

Late publicity! Check our last review regarding the wonderful world of S-#acylation aka #Palmitoylation. A comprehensive overview of the field and our take on the interplay between this #lipid #PTM and #immunity #metabolism #cancer and #brain. https://t.co/JoJuaUG0WC

Now Online Mechanisms and functions of protein S-acylation https://t.co/TUo4vcERXw

💡Viewpoint💡 💫S-acylation: an orchestrator of the life cycle & function of membrane proteins💫 ✍️By @FS_Mesquita, F. Gisou van der Goot et al from @EPFL_en ➡️ https://t.co/ERXytc2zw6 #deacylation #ERassociateddegradation #palmitoylation #proteinturnover #Sacylation #OpenAccess

Big thanks to all our collaborators and everyone from the @VDGLab @Trono_Lab @ACCESS_Unige. Learn more about the details of how cell damage caused by #viruses #toxins or #colitis regulates protein #acylation #palmitoylation, check it out!

Delighted to share our take on the only reversible lipid PTM--S-acylation as a major regulator of protein dynamics and function and its implications in health and disease in @JCellBiol . @gvdgoot Thanks so much. Proud! Highlights in thread (1/7) https://t.co/RaYNZGKKU8

Review: S-acylation is one of the most frequent posttranslational modifications that regulates diverse cellular processes. @MUmairanwar1 and @gvdgoot @EPFL_en discuss the complexity and disease implications of this highly regulated reversible lipidation. https://t.co/u6pE2vQbpB

Finally, we show that #viruses produced by Long-ZDHHC20-expressing cells have enhanced infectivity. More details in the manuscript!

The N-terminal extension of ZDHHC20 prevents the protein from leaving the ER, extends its half-life, and enhances its #Spike modifying capacity by more than 35 times!

This Long-ZDHHC20 is expressed during in vivo #SARS2 infection and also following non-infectious organ damage such as #colitis.

A Great Team Effort! @FS_Mesquita @AbramiLaurence @gvdgoot @Trono_Lab @ACCESS_Unige We show that infection triggers a transcriptional change in the host acyl-transferase ZDHHC20 producing an uncharacterized Longer Version of ZDHHC20 a few hours after initial cellular infection.

#SARS2 #Lipidation Chapter2. How #SARSCoV2 boosts Host #Palmitoylation to promote infectivity! #Infection shifts transcription of ZDHHC20 palmitoyltransferase to increase #Spike Palmitoylation and produce more infectious #virus Stay tuned for Chapter3 https://t.co/81eX8duDjp

Is there more than transcriptional programs to drive cell identity? Here with @GioeleLaManno we discuss the lipotype hypothesis

ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains

This was really a nice journey … thank you @MUmairanwar1 , @oxyquips and @AbramiLaurence for taking us this far…

Thanks to all involved, in particular @oxyquips @AbramiLaurence @gvdgoot @Gio_Dangel0. @VDGLab we have to celebrate. 2/2

How are membrane nanodomains formed? Delighted to share our preprint where we show that plasma membrane compartmentalization is controlled by rapid lipid composition remodeling at the ER-Golgi contact sites. (1/4) https://t.co/Lm7pJLnDmX

Great team effort that characterizes the #viral #lipid composition and shows that host #lipidation is required for #SARS-CoV2 infectivity! @Gio_Dangel0 @matteodp @labriataphd @Trono_Lab @EnyaQing @FS_Mesquita @AbramiLaurence