Melania Bruno
@micro_MelBruno
Followers
83
Following
135
Media
3
Statuses
21
Postdoctoral fellow. Molecular bio(techno)logist/adventurer. Fascinated by the molecular gears that underly life and evolution ⚙️🔬👩🔬. Opinions are my own.
Bethesda, MD
Joined March 2019
I’m excited to share a new preprint from some of my work in the lab of @todd_macfarlan ! 😄. We dived into young KZFP gene clusters in different mouse strains and species to uncover mechanisms that facilitated their evolution and diversification in mice.
Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice #biorxiv_genetic.
1
3
9
RT @Eddie53467802: Super excited to share our latest work just published! 🎉 Grateful for the support of my PI @TakashiAkeraLab and amazin….
nature.com
Nature Communications - In general, the kinetochore position and the sister-chromatid cohesion site are spatially linked. Here, the authors find a meiosis-specific distal cohesion site decoupled...
0
5
0
Huge thanks to all our collaborators for their help and for sharing expertise and data! This work would not have been possible otherwise!.
0
0
0
Our analyses support a model be which new invading ERVs that landed at young KZFP gene clusters likely promoted the expansion and diversification of the KZFP gene repertoire in mice, by facilitating non-allelic homologous recombination events and large segmental duplications
1
0
0
By combining multiple long-read sequencing technologies, we achieved a first detailed comparative analysis of young KZFP gene clusters in the mouse lineage, revealing a previously underestimated heterogeneity of these loci between mouse strains and species
1
0
1
RT @Eddie53467802: For y'all chromosome and centromere lovers, we reveal an incredible feature of chromosome organization by decoupling the….
0
2
0
RT @TakashiAkeraLab: 🚨New preprint on “decoupling the peri-centromere from the kinetochore” in Peromyscus mice🐭 . Congrats to our postdoc @….
biorxiv.org
The primary constriction site of the M-phase chromosome is an established marker for the kinetochore position, often used to determine the karyotype of each species. Underlying this observation is...
0
11
0
Had a wonderful time at #BoG24! So much cool research going on in the field of genome biology and within a great and friendly community!! 😃.Thank you @cshlmeetings for this fantastic meeting!.
1
1
7
RT @todd_macfarlan: Our new preprint on a KRAB zinc finger protein that plays an important role in neural development and mammalian evoluti….
biorxiv.org
Mammalian brains are larger and more densely packed with neurons than reptiles, but the genetic mechanisms underlying the increased connection complexity amongst neurons are unclear. The expression...
0
38
0
RT @dorotheasenft: Join the most recent journey of the @todd_macfarlan lab in @NatureRevGenet, where Todd and I explore how transposable el….
0
37
0
RT @rachellcosby: Check out this cool new paper on evolution of regulatory elements in the placenta! Congrats to Ming-an Sun, @todd_macfarl….
biorxiv.org
In mammals, the placenta mediates maternal-fetal nutrient and waste exchange and provides immunomodulatory actions that facilitate maternal-fetal tolerance. The placenta is highly diversified among...
0
3
0
RT @todd_macfarlan: Check out our now published manuscript on a dual histone H3 methylation reader protein that coevolved with the histone….
elifesciences.org
The meiotic recombination landscape in vertebrates was re-engineered via the co-evolution of a dual histone H3K4/H3K36 methylation 'writer' PRDM9 and its 'reader' ZCWPW1 that facilitates efficient...
0
17
0
RT @todd_macfarlan: Why not spend the long weekend reading a preprint on zinc finger gene evolution and their roles in TE silencing! https:….
biorxiv.org
The Krüppel-associated box zinc finger protein (KRAB-ZFP) family amplified and diversified in mammals by segmental duplications, but the function of the majority of this gene family remains largely...
0
39
0
RT @br1johnny: Thank you @IntelRealSense !. @AutomaUNINA @OpenRoboticsOrg @Inteliot @UPbridge_gap @AWSOpen.@Prusa3D. #robotics #ai #compute….
0
5
0
RT @br1johnny: Merry xmas with my latest bot!. printed on @Prusa3D by @josefprusa and based on @OttoDIY project!. #….
0
5
0
I couldn’t get a pumpkin and went for relatives 😅.Happy halloween 🎃
0
0
2
RT @todd_macfarlan: Our new preprint on the co-evolution of a dual histone methyltransferase (PRDM9) and it’s reader (ZCWPW1) that controls….
biorxiv.org
Meiotic crossovers result from homology-directed repair of double strand breaks (DSBs). Unlike yeast and plants, where DSBs are generated near gene promoters, in many vertebrates, DSBs are enriched...
0
24
0
RT @CedricFeschotte: I started a list of 100+ #WomenInScience running an active lab and recently studying #transposons or #repetitiveDNA.….
docs.google.com
0
90
0