Emmanuel Cazottes
@manucazottes
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Postdoctoral fellow w/ @CarldeBoerPhD @UBC | PhD w/ @CRougeulle @univ_paris_cite | Roamer of the non-coding genome
Joined January 2021
A report made counterintuitive claims that PRC2 binds → more RNA than PTBP1 & hnRNPU → RNAs that do not exist in the cell We found a simple explanation: the authors ignore most RNA in the sample, leading to inflated background & misleading conclusions. https://t.co/F3M9QVP9SQ
biorxiv.org
We recently published biochemical and quantitative evidence that challenges the widespread claims that PRC2 binds directly to many RNAs in vivo . A recent preprint performs a re-analysis of some of...
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We are recruiting a Post doc to work on Epigenetics and Cancer!
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Does 6mA exist in eukaryotic DNA? This is our take on this dispute: yes it does, and can be very abundant, but mostly correlates with presence of the MT-A70 writer AMT1. Then, 6mA is associated with transcriptionally-permissive chromatin (H3K4me3) 1/6:
biorxiv.org
DNA methylation in the form of 5-methylcytosine (5mC) is widespread in eukaryotes, while the presence of N6-methyladenine (6mA) has sparked considerable debate. Methodological disparities in quanti...
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Great opportunity for new PhD students to join us @qcb_usc!
The USC/QBIO department is now accepting applications for the CBB PhD program. Please share with any interested undergraduate and Master's students. https://t.co/VSHj6z2dUe We will have zoom information sessions Nov 1 and 15, please contact me directly for a registration link.
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First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? https://t.co/l7bwPsTSkd (1)
biorxiv.org
Enhancers are critical genetic elements controlling transcription from promoters, but the mechanisms by which they convey regulatory information across large genomic distances remain elusive. Here,...
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[NEW Podcast] We talked with Dr. Claire Rougeulle from @ParisEpigenetix about her work on gene expression control, the intricacies of X-chromosome inactivation & the potential of non-coding RNAs in this process Tune in! https://t.co/s5kdqevD5O
#podcast #epigenetics #Paris2024
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Happy to share the latest publication from the lab: XIST dampens X chromosome activity in a SPEN-dependent manner during early human development https://t.co/aSeOR7HhqV Congrats to @CharbelFeghaly @JeffOui94 @manucazottes @GribnauLab, David lab @ParisEpigenetix
pubmed.ncbi.nlm.nih.gov
XIST (X-inactive specific transcript) long noncoding RNA (lncRNA) is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female...
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🎉 Excited to announce our latest team paper on the role of ESCRT-III protein methylation in abscission regulation! Huge thanks to the team at @WeitzmanlabP and our amazing collaborators! 🔗 Link below 👇🏻 https://t.co/8XzMN8wF6G
nature.com
Nature Communications - Methylation of CHMP2B regulates abscission timing by modulating ESCRT-III dynamics during cytokinesis. This methylation also plays a role in HIV-1 budding, highlighting the...
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Hapoy to share our latest paper after a long but amazing project. Thanks @celinemorey, @CRougeulle and all collaborators. Altered X-chromosome inactivation predisposes to autoimmunity | Science Advances https://t.co/Qnub9cKAI1
@univ_paris_cite
@CNRS
@Inserm
@ParisEpigenetix
science.org
Perturbation of X-chromosome inactivation, a female-specific process, induces signs of lupus, a disease that mostly affects women.
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Tonight, we prepare our speakers and event managers for #pint24 💪🏻 @EloScicomm is sharing all the tips for great nights of science discoveries 🤩🧫🔬🦠 https://t.co/UW8gPbwI8o
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Can scientists be taught how to choose good projects? I took a fantastic class taught by @mfgrp last quarter where the foundational hypothesis is: Yes, they can! And I continually come back to these core insights as I think about project choice and direction in my 2nd year of
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I'm very happy to see that our work on XCI and autoimmunity inspired some discussion. @ParisEpigenetix
#rougeullelab
Today #PreprintHub2 with Laura Gebetsberger @MedUni_Wien had a nice #preprint discussion on how altered #X-chromosome inactivation predisposes to #autoimmunity from @Huret_C & Céline Morey @CRougeulle 🐭👩👇 https://t.co/a6fEqJ4LjK
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✨Retrouvez @manucazottes, de l'équipe @CRougeulle, dans une soirée #pint24 dédiée à l'adaptation ! 👉 https://t.co/UcZH7tWBCq ❗️La billetterie ouvre lundi 8 avril !
pintofscience.fr
Comment évoluerons les espèces que nous connaissons face aux changements rapides de notre environnement ? L'évolution du génome, qui a permis à toutes les …
🎉ÇA Y EST !! Le programme #pint24 de presque toutes les villes est en ligne !! À consulter ici 👉 https://t.co/yYuibjhGZK 👈 🎫Vous avez deux semaines pour le découvrir tranquillement, les tickets seront en ligne lundi 8 avril ! 👓🧠❤️🔥Alors, quelle est votre soirée préférée ?
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Beautiful story from the amazing @TimPollex!! Congrats to all other authors too!
Chromatin gene-gene loops support the cross-regulation of genes with related function https://t.co/ueU7t6SOAG
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Today starts a new era of genome engineering! We use RNA-only delivery to safely and efficiently deliver genes of interest to the human genome! @CollinsRNPLab @berkeleyMCB A thread 🧵: https://t.co/ztmBAeVcbP
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Check out our last paper focusing on altered DNA repair in H3.3 mutant pediatric high-grade glioma! We identified a specific molecular vulnerability with potential for therapeutic targeting. Thank you to our collaborators. https://t.co/LrOqbqDf55
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🚨New paper out! Congratulations @PoloSophie group and collaborators 👏👏👏 👉 https://t.co/8QKrdJTbMV
Check out our last paper focusing on altered DNA repair in H3.3 mutant pediatric high-grade glioma! We identified a specific molecular vulnerability with potential for therapeutic targeting. Thank you to our collaborators. https://t.co/LrOqbqDf55
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We are excited to share with you the work of @manucazottes, nicely posted the day before his thesis defense! With @CharbelFeghaly @agnese_loda @heard_lab @PSavatier and many othersExtensive remodelling of XIST regulatory networks during primate evolution
biorxiv.org
Unravelling how gene regulatory networks are remodelled during evolution is crucial to understand how species adapt to environmental changes. We addressed this question for X-chromosome inactivation,...
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Excited to share our new work about the sequence basis of transcription initiation in human. We showed that simple rules can explain most human promoters, offering fresh insights into transcription initiation and gene regulation https://t.co/Q4Ex0pQUGJ
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