Heard_Lab
@heard_lab
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Joined September 2018
Do you have ambitious plans to study the molecular mechanisms of environmental adaptation in mammalian model systems? Join EMBL Rome as an independent group leader: generous core funding & benefits, top-level students & core facilities. https://t.co/etzGLzeqDk
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📢 New preprint from the lab! CRISPR-screening wizard 🧙 🧬 @TSchwammle figured out how different signals 🚦 are integrated at the Xist locus. See his tweetorial below. https://t.co/DaJ8G2puDm
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EMBL congratulates David Baker, Demis Hassabis, and John Jumper on the 2024 #NobelPrize in Chemistry for their seminal discoveries and developments on protein structures. @nobelprize @demishassabis @GoogleDeepMind
#chemnobel
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First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? https://t.co/l7bwPsTSkd (1)
biorxiv.org
Enhancers are critical genetic elements controlling transcription from promoters, but the mechanisms by which they convey regulatory information across large genomic distances remain elusive. Here,...
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Le Dr @ClaireRougeulle prend ses fonctions en tant que directrice du Centre de recherche à compter de ce 1er septembre 2024. Sa nomination par le Directoire de l’Institut Curie le 3 juillet 2024, marque le début d’un mandat de 5 ans. ➡️ https://t.co/Ks7rZNqz7y
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Really amazing to see how non traditional model organisms are picking up. Here at @janeliaconf and soon… our @embl @EMBO symposium on the « Wild Frontiers of Model Organisms » ! Check it out!! => https://t.co/DGasnLVeyl
@Dey_Gautam @mwdorr @NicoleDubilier Susana Coelho
embl.org
This meeting @HHMIJanelia will bring together researchers to share challenges and successes in the development of new genetic tools for a broad range of non-traditional model organisms and biological problems. Learn more + apply by Oct. 29 @ https://t.co/AZC2xFewW6
@HHMINews
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Congratulations to you both
👏 Congrats to Drs Allison Bardin and Valérie Borde, team leaders at Institut Curie Research Center, selected for their outstanding scientific contributions to join the @EMBO Membership. ➡️ https://t.co/78p7SPeFeL
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Congratulations, Nick Goldman and Mikhail Savitski! Both EMBL group leaders have been elected as EMBO members for their research excellence. They'll be joined by Oliver Billker, a member of the @NordicEMBL Partnership, and many EMBL alumni. https://t.co/gYRyglMjur
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#Science #Biologie "L’interface organisme-environnement" 📌 Colloque en anglais organisé par la Pr Edith Heard, titulaire de la chaire #Épigénétique et mémoire cellulaire ⏰ Les 11 et 12 juin 2024 👉 https://t.co/pGBqetQEcR
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Join us at this year’s meeting on epigenetics at the interface of the organism and its environment, at the College de France on June 11-12th @cdf1530. No registration needed and a fantastic line up of speakers! https://t.co/qeOYpDPXIj
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Massive congrats to @CristinaPolica4 who led this study magnificently over many years. An epic tour de force and a wonderful colleague👏👏 Huge shout out also to co-authors @munafomarzia @SteliosTsagkris #ValentinaCarlini, and all lab members who made this happen🙏
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2nd work from my PhD is out!🤩Mammalian Ogt (enzyme of reversible intracellular glycosylation aka O-GlcNAc) is an X-linked essential gene. We use a complementary approach to the direct removal of O-GlcNAc (the other paper) to study the role of this PTM in embryos: 1/9🧵
Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo https://t.co/7TB9mRnUoQ
#biorxiv_devbio
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Our one and only @HauthAntonia defended her PhD this week: Congratulations Dr. Hauth 🥳🤩🥳🤩 First PhD of the Heard lab @embl - we are all very proud of you 👏👏👏
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Our first pre-print from the lab in collaboration with @Scwin2 T.Moritz @EpiQMAx. @KarlienVN &Co found that metabolic rewiring in early human development aids trophoblast lineage induction via acetylation regulation. Check out: https://t.co/L2PEuowaTO
@reNEW_Global @Metabolcenter
researchsquare.com
Development is driven by a sequence of molecularly interconnected transcriptional, epigenetic, and metabolic changes. Specific metabolites, like α-ketoglutarate (αKG), function as signalling molecu...
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Chromatin gene-gene loops support the cross-regulation of genes with related function https://t.co/ueU7t6SOAG
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Are you a female scientist in Africa looking for an exciting research placement opportunity?👩🔬🔬 Don't miss out on the @UNESCO-@EMBL Residency in Infection Biology! Apply before 31 March, and take your research to the next level! 👉 https://t.co/OdslVnLrsE
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Congratulations to all involved - this is the result of a great collaboration 🤩 @OliverStegle @odom_lab @zauggj @HowardYChang
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Xist’s silencing function also impacts the 3D structure of the inactive X chromosome leading to loss of TAD-like structures in a post developmental context 3/3
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The role of Xist in tuning X-linked gene expression can happen outside of the developmental time window usually thought to trigger X-inactivation and is more flexible and dynamic than expected 2/3
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