Johan Jakobsson
@JakobssonLab
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Director at Lund Stem Cell Center, Professor of Neuroscience at Lund Univ, Stem cells, Epigenetics, microRNA, Reprogramming, Transposons, ERVs, LINE-1
Lund, Sverige
Joined August 2017
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development. A study by @JakobssonLab & co-workers in @CellGenomics #SfN2025
cell.com
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of...
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Updated version of our preprint on how SETDB1-mediated H3K9me3 controls the expression of L1 elements in human neural progenitor cells. The new analysis in this revised version supports a role for active DNA demethylation of L1s in the absence of H3K9me3. https://t.co/q7pXxtcEjb
biorxiv.org
Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However, studying the functional consequences of heterochrom...
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Hominoid-specific retrotransposons fuel regulatory novelty in early brain development
cell.com
Transposable elements can drive genetic innovation. In this issue of Cell Genomics, Adami et al. investigate the impact of hominoid-specific L1 retrotransposons on early embryonic and brain develop...
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LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
cell.com
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of...
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Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson’s disease https://t.co/eBbvgIBqx4
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New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons in the human brain. https://t.co/nG67CJSVuO
biorxiv.org
Parkinson’s disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to...
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LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
cell.com
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of...
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New paper from our lab! We found that LINE-1 transposons contribute to early human brain development. @CellGenomics
https://t.co/8UlRLZGR3q
cell.com
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of...
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#TransposonDay2025 New manuscript from our center to which we contributed. Provides a mechanistic explanation for how L1s are silenced during early human development. https://t.co/CjHMa2MBr8
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New preprint from our lab! Why is not everyone working on Transposons? Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons https://t.co/eROIUMKtae
biorxiv.org
Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and associated with the histone mark H3K9me3. Heterochromatin erosion is a hallmark of human ageing and H3K9me3...
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New preprint from our lab! Why is not everyone working on Transposons? Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons https://t.co/eROIUMKtae
biorxiv.org
Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and associated with the histone mark H3K9me3. Heterochromatin erosion is a hallmark of human ageing and H3K9me3...
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In our latest preprint, we introduce the first human cell-type-specific brain aging clocks from high-precision postmortem samples. Using single-cell transcriptomics, we uncover distinct aging patterns and new insights into neurodegeneration. #BrainAging
https://t.co/dQzo7VK0KT
biorxiv.org
Aging is the primary risk factor for most neurodegenerative diseases, yet the cell-type-specific progression of brain aging remains poorly understood. Here, we developed human cell-type-specific...
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New preprint from our lab! Great collaboration with the labs of Karolina Pircs and Csaba Kerepesi from Budapest. We built molecular aging clocks for the human brain using single-nuclei RNA-seq data. https://t.co/ouz0pHfNU8
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New preprint from our lab! Great collaboration with the labs of Karolina Pircs and Csaba Kerepesi from Budapest. We built molecular aging clocks for the human brain using single-nuclei RNA-seq data. https://t.co/ouz0pHfNU8
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New pre-print from our lab. Led by the outstanding @aniada97 and Raquel Garza. LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development. https://t.co/TAt9JugKOF
biorxiv.org
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human developm...
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...on another note: this is the last post from this account. From now on you can find us on Linkedin and Bluesky.
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I am convinced that our center will continue to be one of the best places for life science research in Europe and I am looking forward to focusing all my attention on transposon research... (why isn't everyone working on transposons?). Happy New Year!
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Tomorrow is my last day as Director of the Lund Stem Cell Center (@Lund_Stem) . It has been a fantastic four years and I am so happy to pass over the torch to my close colleague Malin Parmar, who will lead the center together with Göran Karlsson in the coming years.
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