Natalie Krahmer
@NatalieKrahmer
Followers
1K
Following
3K
Media
43
Statuses
752
Group leader at the Helmholtz Diabetes Center studying cellular processes in metabolic diseases, organelles, metabolic signaling. ❤️ #lipiddroplets #proteomics
München, Bayern
Joined May 2018
How do adipocytes get fat? Excited to share new work from my lab! Felix Klingelhuber and Scott Frendo-Cumbo from the Mejhert&Rydén lab used proteomics to map how adipocytes rearrange their architecture and spatial metabolic organization in adipogenesis. https://t.co/q9woJuhfwd
nature.com
Nature Metabolism - Klingelhuber, Frendo-Cumbo et al. develop a proteomic atlas elucidating the intracellular spatiotemporal changes in protein levels and localizations during human adipogenesis.
23
49
204
The pathogenesis of hepatic steatosis in MASLD: A lipid droplet perspective A Viewpoint by Natalie Krahmer @NatalieKrahmer, Tobias C Walther @TobiWalther, & Robert Farese, Jr @FandWLab @MSKCancerCenter
https://t.co/3NUAMvc8uF
0
4
12
Happy to share our viewpoint on the role of lipid droplets in MASLD with @fandw JCI - The pathogenesis of hepatic steatosis in MASLD: a lipid droplet perspective
0
0
5
Applications are open for early-career researchers to attend our workshop on “Revisiting Metabolic Fundamentals” April 26-29, 2026 in East Sussex, UK.
biologists.com
Revisiting Metabolic Fundamentals This Workshop will bring together a diverse group of scientists whose work challenges and redefines traditional views of metabolism, for example uncovering new...
1
25
72
Apply today and be part of inspiring science! Deadline July 23rd! #Proteomics #Postdocs
My lab is hiring a postdoc for translational research in inflammatory skin diseases using cutting-edge proteomics Join us @MPI_Biochem. All the infos here 🔍 https://t.co/NWwWPqKgYm Apply until July 23. Please RT.
0
6
20
I’m thrilled to share that the main work of my PhD has been published @Cancer_Cell! With @labs_mann & @ErnstLengyel, we analyzed the progression from ovarian serous borderline tumors to invasive cancer using spatial proteo-transcriptomics and identified new therapeutic targets.
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination. https://t.co/H0gYSr1RIc
9
8
31
Our new preprint on metabolic adaptation of the nucleus vacuole junction NVJ is online! Big thank you to @MarieHugenroth and all authors! #MembraneContactSite
https://t.co/Dvm90Hj6xY
biorxiv.org
The nucleus vacuole junction NVJ in yeast is a multifunctional contact site between the nuclear ER membrane and the vacuole with diverse roles in lipid metabolism, transfer and storage. Adaptation of...
5
6
35
.@joanavferreira, Carvalho et al. show that the integrity of multiple ER membrane contact sites requires Pex30 binding to phosphatidic acid via its dysferlin domain, & that Pex30 activity is regulated by phosphorylation in response to metabolic cues https://t.co/Sn5a1azkIi
1
9
47
Online today in @Nature - our latest study led by superstar postdoc @GillesRademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer https://t.co/czMQcNSr7o full text available here 👉 https://t.co/JVFBDWxcTo and thread 👇
nature.com
Nature - PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver...
36
73
326
The abstract submission deadline for the 2nd edition of our #EMBOLipidDroplets Workshop (21-26 September 2025) is approaching. Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025! @EMBO
@Co_Biologists
https://t.co/ytoQzXt3Oj
0
15
50
Excited to introduce LipidCruncher from our lab @FandWLab, led by @HamedAb82149117! A web-based platform streamlines lipidomic data analysis. From standardization, filtering , quality checking to advanced visualizations. #Lipidomics #DataVisualization
https://t.co/aHvyfQNNOE
biorxiv.org
Advances in mass spectrometry (MS)-based lipidomics have led to a surge in data volume, underscoring a need for robust tools to evaluate and visualize these data comprehensively. Current workflows...
1
16
43
⏰ Don’t miss the chance to apply for this postdoc opportunity in spatial & single-cell proteomics in our lab @karolinskainst! Plenty of exciting resources and projects on mitochondria and metabolism. Deadline: May 5 👉 https://t.co/s2OwyTqWMa
#mitochondria #metabolism #singlecell
ki.varbi.com
Postdoctoral studies in Spatial Single-Cell Proteomics of Metabolic Stress (scholarship) Do you want to contribute to improving human health with novel technology? Single-cell proteomics by mass spect
1
3
10
New! Online now: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging https://t.co/q38CqvYl19
5
65
251
There a lot of use of NAD+ supplements out there, without evidence of anti-aging effects in people. Here's some new data that detracts from NAD's role in modulating the aging process
cell.com
NAD depletion in skeletal muscle does not impair tissue integrity and function or accelerate aging, as shown in a mouse model with an 85% decrease in muscle NAD+ levels. Muscle structure, metabolism,...
3
32
130
Our latest work, led by @__btjackson and Angela Montero @MSKCancerCenter demonstrates how intracellular metabolic gradients induce dependence on exogenous pyruvate in embryonic stem cells
12
46
261
Intracellular metabolic gradients dictate dependence on exogenous pyruvate
nature.com
Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...
0
10
50
RESEARCH | @NicolaisenSand, B Kiens et al. (@UCPH_Research) Dietary protein restriction in healthy, lean men elicits increased energy intake to maintain body weight, driven in part by FGF21-mediated alterations to adipose tissue mitochondria. https://t.co/pVJUjhjhNw
nature.com
Nature Metabolism - Dietary protein restriction in healthy, lean men elicits an increased energy intake to maintain body weight, which is driven, at least in part, by FGF21-mediated alterations to...
0
5
24
Our paper is out in @Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution. Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time. https://t.co/ZpmXqsn1HC
nature.com
Nature - High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and...
2
24
97
Excited to have contributed! Single-cell image representations generated using scPortrait and DL allowed us to identify molecular processes behind different aggregate morphologies in AADT #Alpha1Awareness Check out scPortrait for your own projects https://t.co/GErkdgCHx1
#scverse
github.com
scPortrait is a scalable toolkit to generate single-cell representations from raw microscopy images - MannLabs/scPortrait
Our paper is out in @Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution. Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time. https://t.co/ZpmXqsn1HC
2
2
6
Twenty years of genome-wide association studies. Always worth reading @EleZeggini
nature.com
Nature - The first robust association between a genetic variant and disease risk.
0
6
19
I can only recommend! Cool technology, super interesting topic and the best PI😀 can I also apply?
Keen on a cutting-edge postdoc at the interface of bio and tech? Join us at Karolinska Institutet to unravel metabolic stress with spatial single-cell proteomics. Apply by May 5! https://t.co/C6AKKbS8Rs
#proteomics #postdoc #mitochondria #spatialbiology 👉
0
0
2