Lior Pachter
@lpachter
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Bren Professor of Computational Biology @caltech. Blog at https://t.co/FFQzhEsmhi. Tweets represent my views, not my employer's. #methodsmatter
Pasadena, CA
Joined April 2009
Same manipulation that Ferrero uses to advertise Tic Tacs as sugar free (and have people believe them).
I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:
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If this is how the math on the Manhattan project was done they'd probably still have made the movie but Oppenheimer would have been played by Rowan Atkinson.
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Here we go again. Another paper showing that putting arrows on UMAPs (RNA velocity) is biological gobbledygook. How many more such papers are needed?.
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"Every human life is equally valid" says person whose company ranks embryos from "most valid" to "least valid" according to scores (whose computation the person claims is a trade secret), so that the "least valid" embryos can be discarded.
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RT @sinabooeshaghi: A company claiming GPT-5 is a “legitimate PhD-level expert” has clearly never sent it to group meeting to defend this b….
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This is not true. Identical twins do not share 100% identical DNA. Close but no dice.
nature.com
Nature Genetics - Whole-genome sequencing of monozygotic twins, along with their parents, spouses and children, identifies postzygotic mutations present in the somatic tissue of one twin, but not...
The science is simple but powerful:. Identical twins share 100% of their genes. Fraternal twins share 50% (like regular siblings). By comparing how similar identical twins are versus fraternal twins, researchers can measure genetic influence on any trait.
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RT @Graham_Coop: These embryo-selection startups are clearly feeding into an alt-right ecosystem that revels in techno-futurism much as suc….
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RT @Graham_Coop: It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium o….
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RT @arubikscube: whoops, almost found SRA IDs manually. god bless easy to use command line tools.
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This is a good article and I agree with its argument for comprehensible research.
How can we reform science? I have some ideas. But I am not sure you’ll like them, because they don’t promise much.
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RT @SternLab: Given incredibly difficult, conflict-filled years,it makes me proud to present @BZman101 beautiful work on intra-host evoluti….
academic.oup.com
Abstract. In rare individuals with a severely immunocompromised system, chronic infections of SARS-CoV-2 may develop, where the virus replicates in the bod
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RT @kenbwork: @jajoosam @lpachter @sinabooeshaghi Sina's recorded defense is an awesome resource for those interested: .
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aka PCA.
Most tech people know about ordinary least-squares (OLS), but not so much about *total* least-squares (TLS). They measure fit differently: OLS minimizes sum of sq. distances along dependent variable; whereas TLS minimizes sum of orthogonal distances from data to fit line. 1/2
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The confiscation of cell phones from children at schools & summer camps is largely the result of a national campaign by @JonHaidt. But cell phones are safety devices used for notification & early warnings of active shooters, earthquakes, floods, tornados, tsunamis, wildfires, .
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