Meghan Conn
@MeghanConn01
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Graduate student researching immunometabolism in the @SchertzerLab at @McMasterU 🧬🔬
Hamilton, Ontario
Joined September 2023
RT @DanielJDrucker: Continuous insulin monitoring holds promise for personalized treatment strategies in diabetes management..
nature.com
Nature Biomedical Engineering - Integrating microneedle patches with insulin sensors enables continuous tracking of insulin levels in the interstitial fluid of diabetic rat models.
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RT @NatMetabolism: Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric ox….
nature.com
Nature Metabolism - John et al. show that upon classical activation, macrophages undergo nitric oxide-driven reprogramming of nucleotide metabolism, which affects immune functions and responses.
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RT @DanielJDrucker: Here the authors propose that gut #microbiota derived peptides exhibit potential for prevention and treatment of human….
nature.com
Nature Microbiology - Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents.
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RT @Cell_Metabolism: New! Online now: Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in ob….
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RT @DanielJDrucker: A flagellin Toll-like receptor 5 (TLR5) peptide YY (PYY)-labelled colonic neuropod cell axis leads to PYY release onto….
nature.com
Nature - A study reveals a gut–brain sensory pathway through which the microbial component flagellin activates neuropod cells in the colon to signal the brain and reduce feeding in mice.
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RT @CellPressNews: Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation. Read the f….
cell.com
GLP-1R agonists may reduce cardiometabolic complications in part through reduction of inflammation. Here we show, using pharmacology and genetics, that the anti-inflammatory actions of GLP-1RAs to...
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RT @NatMetabolism: RESEARCH | PD Cani, @RubenNogueiras, @ClaretLab et al. (UCLouvain, U de Santiago de Compostela, U Barcelona):. Metabolic….
nature.com
Nature Metabolism - Toledo et al. show that metabolic hormones acting in the hypothalamus, along with direct manipulation of hypothalamic neurons, can drive remodelling of microbial communities in...
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RT @DanielJDrucker: Dozens of studies illustrate the feasibility of engineering probiotics to secrete GLP-1 and Rx #diabetes in mice. https….
tandfonline.com
Diabetes mellitus (DM) is a complex metabolic disease characterized by hyperglycemia. Recently, the incidence of diabetes has increased exponentially, and it is estimated to become the seventh lead...
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RT @adipose_papers: Insulin Prevents Fat Loss and Promotes Muscle Loss During Intermittent Fasting in Obesity
biorxiv.org
Elevated blood glucose, insulin, and insulin resistance are associated with obesity and type 2 diabetes (T2D). High blood insulin levels blunt lipolysis and promote lipogenesis, and thus weight gain....
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RT @Nature: Nature research paper: Kupffer cell programming by maternal obesity triggers fatty liver disease.
nature.com
Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
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RT @APSPublications: 🆕@physiolrev, This review highlights the molecular mechanisms that regulate glucose utilization in skeletal muscle, th….
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RT @DiabetologiaJnl: .@ralen30 & @irmagarm et al from @FatlivL @IIBmCSICUAM report key role of lipotoxic hepatocyte-derived extracellular v….
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RT @DanielJDrucker: Enthusiasm for targeting #microbiota #MASH continues "A deeper understanding of the roles of the gut microbiota and mi….
cell.com
In this review, Luo et al. examine the role of gut microbial enzymes in the progression of metabolic dysfunction-associated steatohepatitis (MASH). A series of potential future therapeutic regimens...
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RT @Cell_Metabolism: New! Online now: FGF21 reverses MASH through coordinated actions on the CNS and liver https:/….
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RT @DanielJDrucker: A new review highlighting the intricate relationship between the gut microbiome and enteroendocrine cells, with new in….
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RT @MacMODR: Also presenting on March 6 is Meghan Conn – 2nd year MSc (c) in the @SchertzerLab. @MeghanConn01's presentation will describe….
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RT @Cell_Metabolism: New! Online now: Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy bala….
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RT @SchertzerLab: Microbiota protect against frailty, loss of skeletal muscle, and maintain inflammatory tone during aging in mice https://….
journals.physiology.org
Chronic low-level inflammation or “inflammaging” is hypothesized to contribute to sarcopenia and frailty. Resident microbiota are thought to promote inflammaging, frailty, and loss of skeletal muscle...
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RT @DanielJDrucker: New molecular pathways thru which the mouse CNS senses and controls energy balance via CNS regulation of adipose tissue….
cell.com
Passini et al. found that mice lacking Runx3/PV sensory neurons or lacking Piezo2 in these neurons exhibit a systemic metabolic phenotype with browning/beiging of adipose tissues. Finding Runx3/PV...
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