Jonathan Schertzer (SchertzerLab)
@SchertzerLab
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Immunometabolism research: Diet, microbes, drugs and hormones
McMaster University
Joined December 2012
T cell cholesterol transport links intestinal immune responses to dietary lipid absorption
science.org
The intrinsic pathways that control membrane organization in immune cells and their impact on cellular functions are poorly defined. We found that the nonvesicular cholesterol transporter Aster-A...
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Inflammation is a key driver of the pathophysiology of cardiometabolic disorders #obesity #T2D and new metabolic medicines based on GLP-1 action exert their magic in part by reducing inflammation. A new review from Professor Donath summarizes the field https://t.co/7mDWLvqvyw
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A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals
nature.com
Nature Metabolism - The glucagon-like peptide 1 receptor agonist (GLP-1RA) class of medicines has emerged as transformative for the treatment of diabetes, obesity and other diseases. On the...
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Structure of gut microbial glycolipid modulates host inflammatory response
cell.com
Structural variations in the number of acyl chains and phosphate groups of gram-negative microbial lipid A differentially modulate DC-derived IFN-β responses, which are mechanistically regulated by...
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Portal vein-enriched metabolites as intermediate regulators of the gut microbiome in insulin resistance
cell.com
Muñoz et al. show that circulating metabolites are differentially enriched in portal versus peripheral blood. Enrichment patterns are influenced by diet, host genetics, and the gut microbiome. These...
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Quantifying the varying harvest of fermentation products from the human gut microbiota
cell.com
Fermentation products are the most abundant gut microbial metabolites absorbed by the host, with important dose-dependent consequences for health. In this study, we present a systems-level analysis...
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Continuous insulin monitoring holds promise for personalized treatment strategies in diabetes management https://t.co/wc7XsgvMqH
nature.com
Nature Biomedical Engineering - Integrating microneedle patches with insulin sensors enables continuous tracking of insulin levels in the interstitial fluid of diabetic rat models.
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Stressomic: A wearable microfluidic biosensor for dynamic profiling of multiple stress hormones in sweat
science.org
A wearable sensor enables dynamic and noninvasive monitoring of multiple stress hormones to personalize stress management.
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Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution
nature.com
Nature Metabolism - Certo, Pontarini et al. provide insight into the metabolic requirements of ectopic lymphoid structure (ELS) assembly in the context of autoimmunity, and show that blocking...
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🧬 BREAKING: Our CRISPR-GPT paper is out TODAY in Nature Biomedical Engineering @natBME ! 🤯 We built an AI agent that turns ANYONE into a gene-editing expert in 1 DAY instead of months. An undergrad with ZERO experience achieved 90%+ editing efficiency on their FIRST attempt. 🧵
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Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism
nature.com
Nature Microbiology - Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents.
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Liver cancer rates are📈in Canada, driven by #fattyliverdisease 🔗to #obesity & #diabetes. Current treatments are limited. Researchers @MacMODR & #EspervitaTherapeutics developed a drug that blocks fat production in tumors, helping #Bcells attack cancer.
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ACLY inhibition promotes tumour immunity and suppresses liver cancer
nature.com
Nature - Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current...
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New! Online now: Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice https://t.co/pEvlxJ5C32
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Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice: Cell Metabolism
cell.com
D-lactate from the gut microbiota influences blood glucose and fatty liver disease. Trapping D-lactate in the gut improves blood glucose and lowers liver inflammation and fibrosis during obesity.
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Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation
cell.com
GLP-1R agonists may reduce cardiometabolic complications in part through reduction of inflammation. Here we show, using pharmacology and genetics, that the anti-inflammatory actions of GLP-1RAs to...
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Dual hotel to break ground in McMaster Innovation Park
thespec.com
Hyatt Place is meant for short-term travellers, while Hyatt House is meant for longer stays
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Gut commensal Phascolarctobacterium faecium retunes innate immunity to mitigate obesity and metabolic disease in mice
nature.com
Nature Microbiology - Gut microbiome member, Phascolarctobacterium faecium, mitigates the inflammatory phenotype associated with obesity by retuning the innate immune response in a mouse model of...
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@APSPhysiology hosted the symposium "The impact of diet on metabolic health and disease" on April 27th in the American Physiology Summit #APS2025 in #Baltimore. This session was co-chaired by Dr. Weiqin Chen (@AUG_University) and Dr. Sridhar Radhakrishnan (@ResearchDiets), and
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