Mancias Lab
@ManciasLab
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#PancreaticCancer Research Lab interested in selective #autophagy, iron, therapeutic resistance, and #proteomics. @DanaFarber, @BrighamWomens, @harvardmed
Boston, MA
Joined May 2017
The Mancias Lab @DanaFarber is fighting #PancreaticCancer on #WorldPancreaticCancerDay #WPCD2017 #WPCD #PANCaware #DemandBetter @PanCAN
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Excited to share our latest story @NatureComms. Here, we used quantitative proteomics, metabolomics and in vitro/in vivo CRISPR screens to define mechanisms of resistance to DHODHi in PDAC and propose combinatorial approaches with BCL-XL inhibitors: https://t.co/I5iqDhiSGc
nature.com
Nature Communications - Pharmacologic inhibition of dihydroorotate dehydrogenase (DHODH) shows limited efficacy in pancreatic ductal adenocarcinoma (PDAC) models. Here the authors find that...
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How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer? A new role for an autophagy receptor IRGQ in this process with a clinical relevance for the development of liver carcinoma in humans and mice 😊😀 https://t.co/iH8YXDz0X9
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During the keynote addresses at #AACRpan24, Eileen M. O’Reilly and Joseph D. Mancias discussed how understanding pancreatic cancer’s strengths can help researchers uncover its weaknesses. Learn more on the #AACRBlog: https://t.co/JtuLTYJxAU
@EileenMOReilly @ManciasLab
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Joseph D. Mancias discussed "Targeting Autophagy in Pancreatic Cancer" in a Rising Star Keynote Lecture during the AACR Special Conference on Advances in Pancreatic Cancer Research. #AACRpan24 @ManciasLab
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The (almost) full program is now online with an amazing lineup of speakers! #AACRPan24
@EileenMOReilly @ManciasLab @DrJashDatta @TeresaZimmers @DrHendifar @JanowitzTobias @wantong_yao @MaraShermanLab @KenOliveLab @andrewaguirremd @cjder23 @bryant_kl @pratt_ed @mggoggins
Abstract submissions are now open for the @AACR special conference on #PancreaticCancer #AACRPan24 Outline of proposed program below: https://t.co/8wSYAL6Mde
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WE ARE HIRING! We are looking for a motivated postdoc to work on a fully-funded project studying the role of iron metabolism in drug resistance in pancreatic cancer. 3 weeks left to apply. Please spread the word. https://t.co/I4WInQ5Oei
https://t.co/2WjWf3aqLV
au.dk
Ledig stilling ved Institut for Biomedicin - Forskning og uddannelse, Syd, Aarhus Universitet
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Our #OpenAccess review on #PancreaticCancer - advances & challenges is now online at @CellCellPress Many thanks to @CJHPhD @Pasca_Lab & @LyssiotisLab for all the hard work & @jiaying_tan6 for the opportunity. It’s FREE to read so share widely! https://t.co/9R8RHGb62X
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We are so inspired by patients like Candace and her experience. With a loving and supportive family and the latest treatments at @DanaFarber, Candace is a source of hope for more patients with pancreatic cancer.
blog.dana-farber.org
Published: February 6, 2023Written by: Saul WisniaAfter losing her first husband of 30 years to cancer, Candace “Candy” Langford felt blessed to find love again. And when she learned six weeks after...
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Researchers at @DanaFarber and other institutions recently made important discoveries into the recycling system of pancreatic cancer cells, a promising step toward targeted therapies for one of the most challenging cancers.
blog.dana-farber.org
Published: December 28, 2022Updated: December 29, 2022Written by: Rob LevyMedically Reviewed By: Joseph D. Mancias, MD, PhDPancreatic cancer cells operate a recycling program that would be the envy...
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Pancreatic cancer cells operate a recycling program that would be the envy of any municipality — but the only beneficiaries are the cells themselves.
blog.dana-farber.org
Published: December 28, 2022Updated: December 29, 2022Written by: Rob LevyMedically Reviewed By: Joseph D. Mancias, MD, PhDPancreatic cancer cells operate a recycling program that would be the envy...
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A cross-country collaboration between former Damon Runyon-Rachleff Innovators @rushika_perera and @ManciasLab uncovered another way that #PancreaticCancer evades targeted therapies – and a new potential therapeutic target:
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Latest Wolpin-Nowak lab paper on single cell, in situ protein-based characterization of transcriptional subtypes in pancreatic cancer now out in @CR_AACR
https://t.co/8IagesbQDg
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Now online in @CD_AACR: Targeting UGCG Overcomes Resistance to Lysosomal #Autophagy Inhibition by Vaibhav Jain, David Speicher, @AmaravadiRavi and colleagues @TheWistar @PennCancer
https://t.co/VXU3pS6Owt
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Robert Hale's determination in @DanaFarber and the Hale Family's incredible generosity help drive @DanaFarber_Hale closer to a cure for pancreatic cancer. https://t.co/TIJwIueRus
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On the cover!! Thanks @CD_AACR for featuring work from our lab by Miru Ravichandran and @ManciasLab @SantanaCodina on the cover !
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Thanks to @CD_AACR for featuring our stories @ManciasLab and @rushika_perera on the cover of the September issue!
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🚨Job Posting: The @YatrikShahLab & @LyssiotisLab are looking for a postdoc to study the role of iron, O2, & metabolism in erythropoiesis. Opportunities to learn and employ multiple cutting-edge technologies in 2 ~pretty cool labs 😁 DM with interest.
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Happy to share our latest work now out in @nature. At long last, we resolved the structure of the SHOC2-RAS-PP1C complex and integrated this work with deep mutational scanning to comprehensively evaluate #SHOC2 structure and function. 🧵(1/n) https://t.co/PLL95wRA1E
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Two recent preclinical studies highlight the importance of ferritinophagy in pancreatic cancer, with elevation of a ferritinophagy expression signature also predicting poor prognosis in patients with PDAC: https://t.co/XQlkivPDMG and https://t.co/pNcMmehN8B
#PancSM
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