KenOliveLab
@KenOliveLab
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Asc Prof. of Medicine, Columbia University, views own. Pancreatic cancer, translational therapeutics, metabolism, systems, paracrine interactions. It all fits.
New York, NY, USA
Joined August 2018
OK, this one is really meaningful for our whole team. Our preclinical paper on pan-RAS inhibition in pancreatic cancer is now online @Nature. Led by OliveLab student @ulawasko and Revolution Medicines colleagues JingJing Jiang and Mallika Singh.
nature.com
Nature - RMC-7977, a multi-selective RAS(ON) inhibitor, exhibits potent tumour-selective activity in multiple pre-clinical models of pancreatic ductal adenocarcinoma through a combination of...
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Sad to miss the first #PCAMChat24. Briefly, this is Ken Olive from @columbiacancer. I lead a translational research lab dedicated to #PDAC research. Excited to join in for part 2!
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Suddenly seeing a huge number of fellow scientists show up on BlueSky. FYI I'm one of them. Come follow me: @kenolivelab.bsky.social
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ICYMI, the new issue of @CR_AACR is online and features the print version of the In Focus commentary #PancreaticCancer–Associated Fibroblasts: Where Do We Go from Here? https://t.co/0FufRFesQI By Eileen Carpenter, @DebVendramini @MC_Hasselluhn @MaraShermanLab @Pasca_Lab
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New post on our website with updated information on the clinical development of RAS inhibitors for pancreatic cancer. I'll summarize on twitter sooner, but here's the full version:
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On behalf of our Phase I program @columbiacancer , proud of @bherzbergmd presenting exciting initial data on IDE397 in MTAP-del tumors at the @EORTC - @theNCI - @AACR conference https://t.co/Rnppvrh1aI We are excited to offer this study to our patients
ir.ideayabio.com
~33% ORR by RECIST 1.1: 1 CR + 8 PRs out of 27 evaluable heavily pre-treated (median 2-3 prior lines, ranging from 1-7) MTAP-deletion UC and NSCLC patients 9 of 9 responses have confirmed by...
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Really excited for my postdoc @MC_Hasselluhn who received a 4th percentile score on her K99 application. Folks, she's on the job market!
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Revolution Medicines has launched its ph 3 study of RMC-6236 (RASolute 302) in patients with previously treated #PancreaticCancer. 1:1 randomization against physician’s choice of chemotherapy. A registration trial for KRAS inhibitor in pancreatic cancer! https://t.co/lyJx3lCI2M
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There is a new tool on BioIcons to turn any protein (in PDB format) into a 2D vector illustration in SVG format. You can upload any PDB file or import from PDB, AlphaFoldDB or ESMFoldDB. Feedback welcome :) https://t.co/grMysO8JV5
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We are thrilled to welcome Michel Sadelain, MD, PhD, a global pioneer in CAR-T therapies, to Columbia and the HICCC.
Columbia welcomes CAR-T pioneer Michel Sadelain, MD, PhD, as the inaugural director of the new Columbia Initiative for Cell Engineering and Therapy and director of the Cancer Cell Therapy Initiative at the Herbert Irving Comprehensive Cancer Center. ➡️ https://t.co/g8OhtIBMxG
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I am excited to see this story by my talented Master's Student, Kristina Høj. Her research dives into age-related decline in pancreas regeneration and how it’s linked to a proinflammatory response to injury. @AGA_GHAdvances,@UCPH_BRIC, https://t.co/43Jq2nefoI
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New online perspective article @CR_AACR article timed with the ongoing #PancreaticCancer stroma session at #AACRPan24 Pancreatic Cancer-Associated Fibroblasts: Where do we go from here? A conversation with three experts on the PDAC stroma (@MaraShermanLab @ednacukierman &
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Hiring committees take note...
That feeling when you submit your first application for a tenure-track faculty! 🧑🔬 I am planing to create a "Translational systems oncology" laboratory focused on cell states, hypoxia and targeted therapies where I will use both wet and dry approaches. #faculty #academiclife
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Congratulations to CU-DLDRC Associate Director, Timothy Wang, MD, who is the new Vice Chair for Academic Programs for the Department of Medicine at the Vagelos College of Physicians and Surgeons! Dr Wang will add this new role to his portfolio effective September 3rd, 2024.
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@NwosuLab @CornellMBG has opened a call for postdoc applicants. Please kindly repost and or forward to potential applicants. Job posting: https://t.co/zw5qcPNEnW Lab website:
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Proud to have helped launch the Columbia Early Onset Colorectal Cancer Program @columbiacancer @nyp with @BDionigiMD and Yoanna Pumpalova. https://t.co/NGPKX7omJN
cancer.columbia.edu
The Early Onset Colorectal Cancer Program at Columbia Cancer Center is one of the first of its kind dedicated to young people who have been diagnosed with colorectal cancer.
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The Olive Lab is looking for a postdoc to lead our translational program on RAS inhibition in pancreatic cancer. Should have exceptional scientific and project management skills, and experience with transdisciplinary research. Must be a good human.
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Really exciting times for the PDAC field, offering real hope for patients. This is just monotherapy. Can't wait to see combinations!
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They present a preliminary design of a planned Phase 3 trial in 2nd line PDAC patients, randomized to physician's choice.
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