1. Hi #RNA friends, just in time for the holidays I am excited to share the latest pre-print from my group. We solved the structure of a mysterious viral RNA that resists degradation by host nucleases. A short 🧵 & link below – please also check out the full video! #lovevirology

Our latest work is out in @Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 https://t.co/THosKn33fC

🧑‍🔬Are you thinking of doing a PostDoc? We would LOVE to “CU” here!🎉 Come to PEAKS, our Postdoc Recruitment event taking place April 7-8, 2025! 🧪 Present your Thesis work 🧑‍🏫 Meet our Faculty 🏫 Campus Tours 🤝 Networking Opportunities 💬  Engage with the CU Anschutz Community

Pleased to share our new article "Direct testing of natural twister ribozymes from over a thousand organisms reveals a broad tolerance for structural imperfections" out in @NAR_Open https://t.co/l7OqjQGv8c

Interested in grad school in Chemistry & Biochemistry? Check out our virtual open house! @ucsc @shaunmckinnie @partchlab @RubinLabUCSC @prion_disease @sarahloerch1

Paper alert! First high-res endogenously (blended) purified C elegans Ribosome SPA structure is out @RNAJournal Thanks @CryoEM_PNCC for all the (once again!) outstanding support! https://t.co/CoE7CKaY4z

In 2018 our lab began an outreach program with a local middle school, inspired in large part by @HittingerLab Wild YEAST Program. We thought we could further engage the students in the process of identifying yeast species and also learn something about S. cerevisiae diversity 1/n

Finally, thank you to so many more people who graciously shared their application materials, read my proposals, listened to practice talks, or gave me advice about the job market. If you’ll be applying in the coming years, don’t hesitate to reach out!

Huge thank you to all my mentors, both formal and informal throughout my training - especially those who wrote me reference letters. I couldn’t have done it without you! I’m very grateful to the @JCChildsFund Fellowship for supporting my postdoctoral research.

The Sherlock lab will open in 2025 at UC Santa Cruz in the Molecular, Cell & Developmental Biology Department! We will study viral RNA structures that regulate translation. I couldn’t be more excited for this next stage in my career. Go Banana Slugs!

Know an outstanding early-career RNA researcher with an independent research program? Nominate them (self-nominate!) to be considered for the Blumenthal Endowed Lectureship in RNA Biology! https://t.co/N3wYC9v458 @CU_BMG @CUBoulderMCDB @RNASociety @jrRNAscientists

We're getting ready to see you at #RNA2024! Stop by to hear about the latest changes to Rfam https://t.co/FyNkbd3ccn @RfamDB and how we can help you with your RNA research. #RNA24 #ncRNA @EMBL-EBI

So excited for you Lauren! Can’t wait to watch the Hagler lab grow.

Team headed by Olivia Rissland & Jeffrey Kieft @CUAnschutz determined the ribosome cryo-EM structure from the important pathogen Giardia lamblia @BeAScientist @JeffreyKieft https://t.co/4OMeleU9ZC

Interested in doing a postdoc in Seattle? Join us May 7 for Seattle DROP, a virtual biomedical postdoc recruitment event. The first 250 US registrants enjoy lunch via delivery voucher!  Underrepresented candidates are esp encouraged to attend. Register:

Recent lab retreat in State College, PA... joint lab meeting with the @phil_bevilacqua Lab, getting ice cream at @psucreamery...and checking out the Penn State campus. Also lots of team building, good convos, and other misc. science.

Tyrosine-accepting tRNA-like structures are found in two viral families, representing two distinct types in this RNA class that share many features but use distinct structures to mimic the anticodon https://t.co/NbrKR0p4DM

The Chemi-Northern method uses a biotinylated probe (1) to detect purified RNA (2) that has been separated on a gel (3) and blotted to a membrane (4) using chemiluminescence (5) to visualize and quantitate the RNA’s size and abundance (6) https://t.co/RlrcznyE1p

Latest work from the @JagannathanLab led by our recent PhD🎓Divya @sciliator! Peptidyl-tRNA hydrolysis rate influences the efficiency of nonsense-mediated mRNA decay

Hi! I’m a biochemistry PhD candidate at CUNY seeking a European-based postdoc position. I want to apply my structural bio skills (protein purification, NMR, MS, xtallography) to Origin of Life research. If you know of anything, please DM or email me: dswingle@gradcenter.cuny.edu