Shaun McKinnie
@shaunmckinnie
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Associate Professor of Chemistry/Biochemistry @UCSC #sluglife - organic chemistry/biosynthesis/biocatalysis - aspiring dog father - 🇨🇦➡️🇺🇸 - he/him
Santa Cruz, California
Joined September 2018
Excited to share our latest work on a new subfamily of VHPOs that modify external AQ molecules and rescue bacterial growth! @JacksonBaumga10 drove this interdisciplinary effort with amazing MS imaging support from @nerdcitycat and @DrLauraSanchez! .
biorxiv.org
Site-selective vanadium-dependent haloperoxidases (VHPOs) are a unique enzyme family that catalyze selective halogenation reactions previously characterized within bacterial natural product biosynt...
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RT @DrLauraSanchez: Just touched down in SD for the 20th anniversary symposium of Pier Swim! Looking forward to some science by the ocean @….
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Tenured! . It’s been a remarkable six years at UC Santa Cruz full of many unexpected obstacles but even more triumphs! I’m incredibly proud of the phenomenal team that we’ve assembled and am excited to have the continued opportunity to grow and share our collective successes!
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RT @VikShende: In addition to being a proud member of @moorelabsio, my time at @Scripps_Ocean allowed me to collaborate with natural produ….
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Congrats to Dr. Austin Hopiavuori for giving a masterful dissertation seminar today and being McKinnie lab PhD #2! Austin has done phenomenal work on biosynthetic non-heme iron enzymes and helped quarterback our inaugural CURE lab last year. Very proud of you Dr. Hopiavuori!
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Huge congrats to Dr. Jackson Baumgartner for completing his PhD dissertation seminar! Jackson was an inaugural lab member and has done a phenomenal job exploring VHPO enzymology! Incredibly proud of all your achievements Dr. Baumgartner - thanks for being PhD #1 from the lab!
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RT @Kalkreuter: Our lab at FSU in sunny Florida is looking to hire a fully funded postdoc position in natural products discovery and/or bio….
kalkreuterlab.com
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RT @Ali__Shariati__: We’re living through pretty unusual times, but we’re excited to share good news! Our CRISPRa-programmed #embryo model….
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RT @ZhuoAlexShang1: Thrilled to share our discovery of a novel polyene macrolide antifungal with a unique mechanism of action—targeting fun….
nature.com
Nature - Mandimycin, a polyene macrolide, exhibits strong antifungal activity and possesses a mode of action that is distinct from other compounds of this class.
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RT @Maia_Popova: It was such a pleasure to celebrate today our wonderful colleague, @ChekanLab 🧪 Jon is an exceptional scholar and educator….
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RT @DrLauraSanchez: Check out our new review we wrote with @shaunmckinnie @robbieashepherd looking at the interface of MS for screening l….
pubs.rsc.org
Covering: 2015 to 2024 Mass spectrometry (MS)-based methods have been implemented extensively for enzyme engineering due to their label-free nature, making them suitable for screening a wide range of...
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Also really looking forward to sharing our collaborative work in this area pretty soon! Keep your eyes open here or where the skies are bluer (same handle) for more 👀!.
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Thrilled to team up with @DrLauraSanchez, @robbieashepherd, Conrad, and Alex and summarize a great amount of work around how advances in MS have accelerated high throughput screening for enzyme evolution!.
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RT @biomicat: What is responsible for the halogen specificity & is there a Substrate binding Site in #VHPOs? Learn more about this amazin….
nature.com
Nature Communications - Vanadium-dependent haloperoxidases (VHPOs) are versatile enzymes that catalyze oxidation of halides followed by halogenation of electron-rich substrates, but the factors...
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Phenomenal seminar by @JMWinterlab today at @UCSCscience! Remarkable and inspiring work on Great Salt Lake microbiology, metagenomics, biosynthesis, NP isolation, structure elucidation and so much more - huge thanks for making the trip out here Jackie!
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RT @DrLauraSanchez: Better late than never, loved hosting @MooreLab @UCSCscience we enjoyed a nice hike before this rain curtesy of @shaunm….
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I got a sneak peek of this awesome story in Dec. 2023 by being on Dr. Manasa Ramachandra’s excellent PhD defense committee! And was so impressed that we had to recruit her as a postdoc for our own oxidative cyclase projects! Huge congratulations Manasa, @AvenaRoss and team!.
Activation of Primary C–H Bonds in Oxidative Cyclizations of Tambjamines Catalyzed by Rieske Oxygenases TamC and PtTamC | Journal of the American Chemical Society @queensu @QueensChem @AvenaRoss
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RT @yitang_ucla: In a year with so little to cheer about so far, I am happy to share our manuscript on a copper-dependent halogenase. Unbe….
nature.com
Nature - A halogenase enzyme uses the copper in its active site to catalyse iterative chlorinations on multiple unactivated carbon−hydrogen bonds, enabling carbon−hydrogen...
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Amazing seminar from @awpuri today who shared his lab’s work on microbial chemical ecology, natural product chemistry, biosynthesis, and cool new analytical techniques! Thanks for making the trip out to @UCSCscience!
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