Denis LJ Lafontaine
@LafontaineLab
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RNA Molecular Biology Laboratory - Université Libre de Bruxelles - Ribosome biogenesis, RNA processing, RNA modification, nucleolus, cancer, ribosomopathy
Brussels, Belgium
Joined January 2013
Combining sequencing and imaging, @sofiquinodoz maps the spatiotemporal dynamics of rRNA processing, demonstrating how rRNA serves as both a scaffold and a substrate for the nucleolus—a multiphase, liquid-like structure. https://t.co/FcwCUUDM2N
@brangwynnelab @omenndarlingbio
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Mice with cardiomyocyte-specific knockout of #YTHDF3 subjected to #cardiac stress had no increase in protein synthesis or cardiac hypertrophy. @Crabolli @AccorneroLab @OhioStatePCB @BrownMolBio
https://t.co/EXpMWtqysz
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Our tour de force into the nucleolar world — a stunning exploration of spatial organization and the functional choreography of ribosome biogenesis now out in Nature✨ https://t.co/eZdIYTFyBk Led by @sofiquinodoz, @jiang_lifei, @brangwynnelab, with theory partners @QiweiYu2,
nature.com
Nature - Spatially segregated rRNA processing dictates nucleolar morphology and drives outward progression of pre-ribosomal RNA through nucleolar phases.
Now on the Princeton Engineering and ODBI sites, a new mapping tool that allows researchers to peer deep into cells' inner compartments to watch and control ribosome assembly, shedding new light on the machinery responsible for making proteins.
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Now on the Princeton Engineering and ODBI sites, a new mapping tool that allows researchers to peer deep into cells' inner compartments to watch and control ribosome assembly, shedding new light on the machinery responsible for making proteins.
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RNase L cleaves most tRNAs in the anticodon loops into various tRNA-derived RNAs (tDRs) including 5'-tDRAla that shows a translation inhibitory effect. Some tRNAs are also cleaved in variable loops. https://t.co/hv3SfYZ0wH
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Excited to share our recent work, which addressed a mechanism by which the eukaryotic ribosomes increase the fidelity of mRNA translation than prokaryotic ribosomes through the eukaryote-specific tentacle-like ribosome structure.
academic.oup.com
Abstract. Eukaryotic ribosomes exhibit higher mRNA translation fidelity than prokaryotic ribosomes, partly due to eukaryote-specific ribosomal RNA (rRNA) i
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A PhD position is available to decipher the modus operandi of ribosome-inactivating proteins at Maria Curie-Skłodowska University, Poland 🔬 Cryo-EM, biochemistry, structural biology 📅 Apply by July 31, 2024 🔗 https://t.co/n4HKyUBoXC
#CryoEM #Ribosome
https://t.co/2Ot8f69iud
translacore.eu
Job offer in molecular biology and structural biology. PhD-STUDENT SCHOLARSHIP (for a period of 25 months, with the possibility of extension by 1 yea
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DM me if interested! We have opportunities at all levels.
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We are thrilled to share our exciting collaboration with @GreenLabJHMI , showing that RIOK3 specifically recognizes ubiquitylated human 40S ribosomes and mediates their degradation under amino acid starvation. We even observed the melting 40S!
cell.com
Huang et al. identify a pathway for stress-induced 40S ribosome degradation: 40S ribosomes ubiquitylated by RNF10 are subsequently bound by the atypical kinase RIOK3, which mediates their degradation...
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Charting the epitranscriptomic landscape across RNA biotypes using native RNA nanopore sequencing https://t.co/BPIvV10NNk
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Translation UK 2025 is coming 😊
Looking to attend exciting meetings and training events in 2025? View our calendar, register your interest for a range events including Educational Research in the Biosciences and Translation UK 2025, and be notified when registration opens! https://t.co/o1OtyJWMfW
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A role for the kinetochore protein, NUF2, in ribosome biogenesis | Molecular Biology of the Cell https://t.co/UeuMh3oRdw New paper from ty brown in the Baserga Lab! Fabulous collaboration with @KabecheLab ! @YaleMBB @YaleCancer.
molbiolcell.org
Ribosome biogenesis (RB) is an intricate and evolutionarily conserved process that takes place mainly in the nucleolus and is required for eukaryotic cells to maintain homeostasis, grow in size, and...
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Online Now: Epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures https://t.co/EoEKMKEc70
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Discover how unique ribosome fingerprints could revolutionize early cancer detection with non-invasive, portable scanners able to detect cancer with near-perfect accuracy. #RNA
#CancerResearch #EarlyDetection #Ribosome #Genomics #NanoporeSequencing
science-tldr.com
Discover how unique ribosome fingerprints could revolutionize early cancer detection with non-invasive, portable scanners able to detect cancer with near-perfect accuracy.
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Online Now: Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching https://t.co/yqjEoOVDuW
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Amazing ribosomes and... incredible cytokines 😯👇 P-stalk ribosomes act as master regulators of cytokine-mediated processes: Cell
cell.com
Cytokines remodel the ribosome to incorporate the P-stalk, therefore altering the translation of mRNAs involved in cytokine responses.
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Delighted to co-supervise 2 advertised @BBSRCWhiteRose PhD projects 1- lncRNA function in human papillomavirus life cycle (led by @OncoVirus_Leeds) 2-Building orthogonal ribosome control for engineering biology (led by @eszter_cs ) https://t.co/Ztyq8GFrME
findaphd.com
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