Kabeche Lab
@KabecheLab
Followers
238
Following
60
Media
3
Statuses
31
The Kabeche Lab at Yale University is dedicated to uncovering the mechanisms that drive genome instability.
Joined April 2020
Congratulations to Lilian Kabeche, faculty member @CancerYale @YaleMBB, who has received @ASCBiology Award for Excellence in Research by an Historically Excluded Person. Read more about Lily's research and mentorship of next gen diverse scientists: https://t.co/7YMm2qwRIw
0
2
10
Congratulations to all the winners (including our awesome leader, Lily!)
ASCB is proud to announce the 2024 Honorific Awards! Join us in celebrating the outstanding achievements of our members in research, education, and mentoring. Check out the full list of honorees and their contributions to the life sciences here:
0
0
7
We’re so grateful to everyone who contributed to this project @Yanshen73854711 @CancerYale and for valuable feedback from the community. Let us know what you think!
0
0
0
Although Chk2 and the DNA damage response pathway canonically antagonize mitotic kinases like PLK1 at the G2/M checkpoint, our data shows that this relationship is inverted in mitosis, highlighting how well-characterized interphase signaling pathways can be rewired in mitosis.
1
0
1
We largely know how PLK1 is activated in G2, but the players that regulate PLK1 in mitosis haven’t been fully described—a big gap in understanding how cell division is controlled. We find that Chk2, a DNA damage response kinase, has a novel role to sustain mitotic PLK1 activity
1
0
1
Chk(2) out our most recent work! We’re excited to share our discovery about a new mechanism that controls mitotic PLK1 activity:
biorxiv.org
Polo-like kinase 1 (PLK1) protects against genome instability by ensuring timely and accurate mitotic cell division. PLK1 activity is tightly regulated throughout the cell cycle. Although the...
1
10
36
Excited to see Elizabeth's presentation at the Cell Cycle Club meeting!
PROGRAMME Virtual Cell Cycle Club meeting: Wednesday March 13 3 short talks: Gergely, Mittnacht & @KabecheLab Breakout session talks Keynote: @JanSkotheim Breakout slots still available, deadline this Friday!! To REGISTER or SUMIT abstract @abcam
https://t.co/5VCr6bFv5Q
0
0
3
Great paper from the Sheltzer lab!
New from my lab: we show that a clinical-stage oncology drug from Eli Lilly is mischaracterized, and its true anti-cancer target is EGFR. We also show how in vitro drug assays can be misleading - cellular+genetic methods are needed to determine drug MOAs.
1
0
2
Congratulations @SusanBaserga!! Well deserved!
Congratulations to Yale Cancer Center members, Dr. Susan Baserga @SusanBaserga and Dr. Emily Wang, on their elections to @theNAMedicine, a prestigious honor! @SmilowCancer @YaleMed @YNHH @YaleMBB @YaleGenetics @YaleRadOnc @SEICHE_Yale
0
1
6
Our paper is now online! ATR promotes micronuclei rupture and clearance.
Online Now: ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei https://t.co/kTAEPfcnw5
3
14
46
Great paper by the Simon Lab! @YaleMBB
Another Yale West Campus Nature paper: https://t.co/FymZRO7PxZ Congrats to the Simon lab and collaborators.
0
0
2
Great publication by the Bleichert lab!
Our latest publication is out now! Check out our paper in @embojournal investigating how ORCA facilitates replication initiation in heterochromatin environments. Congrats to @SahuSumon, Babatunde Ekundayo, and @Ashishk1722 on this team effort! https://t.co/BguvCVM4yJ
0
0
3
Congratulations Mandar!! 🍾
Congratulations to #YCBI faculty member Dr. Mandar Muzumdar @MuzumdarLab, for his promotion to Associate Professor! @YaleWestCampus
0
0
1
4-year Lab Anniversary! 🎉 Over the past 4 years, we've changed biological paradigms & published some great papers, obtained 5 grants, presented our work on national and international stages, & created unforgettable memories. Proud of our accomplishments! @YaleMBB @CancerYale
0
4
36
0
0
2
“When we identify all the ways a protein works, we can better predict how drugs targeting that protein will affect patients” – Scientists @KabecheLab discover a multi-tasking protein with potential to protect against disease: https://t.co/wGW1FTPtl3
@CellReports @CancerYale
0
7
17
Excited to share our latest work uncovering a novel mechanism by which ATR protects the genome in the absence of DNA damage! @YaleMBB @CancerYale
https://t.co/gJOso9nCWl
cell.com
Aberrant changes to centromere composition can cause mitotic defects leading to aneuploidy and cancer. Trier et al. identify a non-canonical role for the DNA damage response kinase, ATR, in promoting...
7
10
62
To all the fans of cell division in the New England area, there is still time to register for the 2023 BAMM meeting! The free one day meeting will be held @Yale on May 6th. Use the link to check it out and register!
0
12
20
#Celldivision fans: check out the 2023 BAMM meeting!! This awesome one day free conference will host an exciting set of speakers from the New England area! This year it will be hosted at @Yale University! Submit a short abstract by April 1st for an opportunity to give a talk.
Check out this year’s Boston Area Mitosis & Meiosis (BAMM!) meeting @KabecheLab (Yale), Dan Needleman (Harvard) and I are organizing. Please spread the word and register for a day of exciting cell division biology on May 6, 2023 at Yale.
0
9
12