Puri Fortes
@FortesLab
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Scientist fascinated by how noncoding RNAs impact biomedicine. Energy from family&friends. Love #noncodingRNA, believe in #RNAtherapy, live in @CIMA_unav
Joined May 2021
Congrats!!! Even mooore work!
Busy times ahead. I apologize in advance for potentially taking longer to respond to e-mails for a few years...
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More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. https://t.co/b6hd4AlIoX
biorxiv.org
More than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long...
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Super nice! Congrats
Very happy to share our work in collaboration with @MaiteHuarteLab @ElenaGrossi8 @CIMA_unav. Congratulations to all the people involved. It's been a long journey!
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Las terapias de RNA… nos pueden llevar hasta el infinito y mas alla!
1/ El ARN nos abrió la puerta a las vacunas contra la COVID-19 en tiempo récord.💉 Las terapias de ARN prometen transformar la medicina, pero… ¿Hasta dónde nos pueden llevar?🤔 4️⃣ investigadores de la red #CaixaResearch nos lo explican:👇 https://t.co/V5GxhanWae
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Prkra dimer senses double-stranded RNAs to dictate global translation efficiency
cell.com
Prkra serves as a primary dsRNA sensor in pluripotent cells, restricting RNA virus replication. By dimerizing through dsRBD3, it sequesters eIF2 complexes from the translation machinery and compens...
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Wow!!! Maite! Seguro que les dejas super impresionados! Congrats!!!
Muy contenta de tener la oportunidad de hablar sobre RNAs reguladores en la Real Academia de Ciencias👇
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After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology. Lately, I’ve focused on
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Amazing supervisor 👍
Seeking MSCA Postdoctoral Fellow Candidate - Stress response and immunotherapy
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Don't think I've ever met scientists as terrified/depressed as I've seen in the US this week (and I live in a war zone).
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If you work in the area of the TGF-beta pathway , consider to send your publication to this special issue , where Prof. Gianluigi Giannelli and I are guest editors. TGF-β Signaling in Immunity, Inflammation, Fibrosis and Cancer https://t.co/wS74yjMPuF
#mdpiijms @IJMS_MDPI
mdpi.com
Special Issue in journal International Journal of Molecular Sciences: TGF-β Signaling in Immunity, Inflammation, Fibrosis and Cancer
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Congrats! Great work!!!
happy to see this out! great team effort to integrate data from disparate studies, increasing our knowledge on the response to immunotherapy depending on tumor subtype @GRIB_Barcelona @HMar_research @UPFbiomed
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And super nice number 2 The integrated stress response regulates 18S nonfunctional rRNA decay in mammals: Molecular Cell
cell.com
To maintain translational fidelity, cells degrade decoding-incompetent ribosomes through the 18S nonfunctional rRNA decay (NRD) pathway. Coria et al. demonstrate that the concerted actions of GCN2,...
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Super nice! The integrated stress response regulates 18S nonfunctional rRNA decay in mammals: Molecular Cell
cell.com
To maintain translational fidelity, cells degrade decoding-incompetent ribosomes through the 18S nonfunctional rRNA decay (NRD) pathway. Coria et al. demonstrate that the concerted actions of GCN2,...
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Imaging single endogenous RNA in live cells comes true!
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🗓️¡No te lo pierdas! El 11 de febrero #mujeres referentes en #ciencia expondrán las fases de la investigación desde que comienza en un laboratorio hasta que llega a al paciente, en un evento en el #DíadelaMujerylaNiñaenlaCiencia ➡️Toda la información en https://t.co/ingcj91PKL
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Our updated preprint on the mechanism behind the 1st & only human disease linked to tissue-specific ribosome: fatal heart failure caused by RPL3L mutations. Very proud of this work led by the talented and fearless Michael Murphy @MMurphyCUNY—check out his thread for more details!
Excited to share our new preprint from the @wu_xuebing lab: https://t.co/qvJ1gdN7N3 In it, we identify a gain-of-toxicity mechanism in RPL3L-linked neonatal dilated cardiomyopathy (DCM), challenging the idea that recessive diseases are primarily caused by loss-of-function.
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Congrats!!! I bet you will do amazing things with this funding!!!
Thankful to @ERC_Research, for continuing to support our work!
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🔬Nos reunimos con el equipo de la Dra. María Reig @ma5RN del @hospitalclinic-@idibaps para conocer los últimos avances del proyecto RETO. Avances en el Tratamiento del Cáncer de Hígado: Modificar el Microbioma como Nueva Estrategia para Potenciar la Inmunoterapia, dotado con
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Es inaceptable! @CienciaGob debe dar explicación detallada a @COSCEorg , que representa a un importantísimo número de sociedades científicas. Dónde ha ido el dinero que había reservado para esta convocatoria?
Ante la cancelación por parte del @CienciaGob de la convocatoria de ayudas a la IA, COSCE ha hecho público el siguiente comunicado en el que pedimos "Una explicación detallada y transparente sobre los motivos de dicha cancelación":
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Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time
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