Accornero Lab @AccorneroLab X Profile

Accornero Lab

@AccorneroLab

Followers

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Following

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The Accornero Lab at @brownuniversity studies RNA biology of cardiac and skeletal muscles 🫀💪🧬🔬. Account managed by lab members

https://t.co/6F66YicvJN

Providence, RI

Joined May 2023

Don't wanna be here? Send us removal request.

Accornero Lab

@AccorneroLab

2 years

We're hiring! We are excited to officially announce our recent move to @BrownUniversity in Providence, Rhode Island, USA and are actively recruiting at all levels! If you're interested in basic or translational RNA Biology in cardiac ❤️ or skeletal muscle 💪, contact us!

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Roger Foo

@rsyf2

2 years

That's it for the week at Keystone #KSCardioEpi24. A week of science and fun @PorrelloER @AccorneroLab . Heading back to work @NUSMedicine

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Lorenz Lehmann

@LorenzLehmann

2 years

Leaving #KSCardioEpi24 in Hannover with great impressions and new 💡&collaborations🙌Thanks to the organizers @rsyf2 @PorrelloER @AccorneroLab for an inspiring meeting!🧬🫀

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Accornero Lab

@AccorneroLab

2 years

Beautifully said from our @AccorneroLab MD/PhD alumna @olgagolubeva65! Great job, Olga!

Carol Bradford

@CarolBradfordMD

2 years

🌟 Meet @olgagolubeva65, a third-year medical student at #OSUCOM. Drawn to patient-oriented curriculum, scholarships provide her with financial stability & motivation. Her gratitude to donors is palpable as she hopes to pay it forward one day. #DayOfGiving https://t.co/OaBcDdjwlz

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Accornero Lab

@AccorneroLab

2 years

See below for our latest work in @CircAHA! Great job, Charles, and thanks to our wonderful collaborators across the 🌎 for their help getting this story published! @CatMak23 #m6A #METTL3

Charles P. Rabolli, PhD

@CRabolli

2 years

Happy to share our work published in @CircAHA ! Very grateful to our co-authors, reviewers, editors, and @CircAHA for publishing our study. Read below for a short tweetorial about #m6A #Nanopore #METTL3 and #cardiomyocytes. (1/6) https://t.co/7umW2zyOym

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Accornero Lab

@AccorneroLab

2 years

Our study links post-transcriptional and post-translational events in muscle regulation. Great work Chris and thank you to all our collaborators! @CRabolli @olgagolubeva65 @DaveArnoldLab

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Accornero Lab

@AccorneroLab

2 years

Linking these components, we found downregulation of #SMAD3 inhibitor #SMURF2. (9/10)

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Accornero Lab

@AccorneroLab

2 years

But how does the YTHDF2-ASB2 axis regulate muscle size? We found upregulation of anti-hypertrophic #SMAD3 and transcription of its targets. (8/10)

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Accornero Lab

@AccorneroLab

2 years

In fact, when we block #ASB2 upregulation in overloaded muscles with #siRNA, we see recovery of knockout muscle phenotype! (7/10)

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Accornero Lab

@AccorneroLab

2 years

We saw enhanced #protein decay in knockout muscles and detected a strong induction of #ubiquitin ligase #ASB2 in knockout muscles via LC-MS/MS. (6/10)

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Accornero Lab

@AccorneroLab

2 years

Knockout muscles also fail to respond to surgically induced hypertrophic overload, suggesting that #YTHDF2 promotes muscle growth. (5/10)

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Accornero Lab

@AccorneroLab

2 years

We found that adult muscles lacking #YTHDF2 have smaller #muscle fibers and overall reduced muscle mass. (4/10)

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Accornero Lab

@AccorneroLab

2 years

To do so, we developed a skeletal-muscle specific deletion of #YTHDF2 in mice. (3/10)

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Accornero Lab

@AccorneroLab

2 years

We previously found that #m6A is key to adult muscle homeostasis. Here, we sought to understand how m6A-binding protein #YTHDF2 factors into the equation. (2/10)

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Accornero Lab

@AccorneroLab

2 years

Our latest manuscript "YTHDF2 governs muscle size through a targeted modulation of proteostasis” is out in @NatureComms ! Congratulations Chris and co-authors! Read below to see the highlights of our work (1/10) #m6A #YTHDF2 #SkeletalMuscle @BrownMolBio https://t.co/LhuyEVv1ZB

nature.com

Nature Communications - This study highlights the role of YTHDF2, a protein that recognizes m6A-modified RNA, in determining muscle size. The authors show a post-transcriptional mechanism...

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Pilar Alcaide, PhD

@PilarAlcaidePhD

2 years

#EMBOCardiobiology @EMBO @EMBLEvents @McKinseyLab @JD98119 @CatMak23 Federica Accornero. Nice (jetlag) talks and more to come! #fibroblasts #epigenetics #cardioimmunology

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Francesco Paneni

@FrancescoPaneni

2 years

What a pleasure to have a #Cardiopulse article from the @AccorneroLab, a leading team investigating cardiovascular #epitranscriptomics. This piece will educate cardiologists on emerging mechanisms underpinning gene expression changes in complex disease phenotypes🔥#CardioTwitter

Accornero Lab

@AccorneroLab

2 years

‼️new paper out today in Cardiopulse of the European Heart Journal. Always great working with @ESC_Journals @FrancescoPaneni

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Accornero Lab

@AccorneroLab

2 years

‼️new paper out today in Cardiopulse of the European Heart Journal. Always great working with @ESC_Journals @FrancescoPaneni

Charles P. Rabolli, PhD

@CRabolli

2 years

Out today in Cardiopulse of the European Heart Journal @ESC_Journals! Check out our new paper discussing #RNA modifications, the #Epitranscriptome and #m6A in the🫀 @AccorneroLab @escardio Cardiac cryptographers: cracking the code of the epitranscriptome

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Paneni Lab

@PaneniLab

2 years

Great opportunity!!!

Accornero Lab

@AccorneroLab

2 years

We're hiring! We are excited to officially announce our recent move to @BrownUniversity in Providence, Rhode Island, USA and are actively recruiting at all levels! If you're interested in basic or translational RNA Biology in cardiac ❤️ or skeletal muscle 💪, contact us!

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Accornero Lab

@AccorneroLab

2 years

Also check out some of our recent works:

pubmed.ncbi.nlm.nih.gov

federica accornero - Search Results - PubMed

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