Hongbo Zhao
@hbozhao
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Assistant Professor @UCSanDiego. Biophysics. Active matter. Applied math. Nonequilibrium physics. | Postdoc @Princeton | PhD in ChemE @MIT | BS @Tsinghua_Uni
La Jolla, CA
Joined September 2017
This month, I officially started as an Assistant Professor at @UCSanDiego. I’m thrilled to join the Department of Physics @UCSDPhysics and the Department of Chemistry & Biochemistry in @UCSDPhySci. I’m especially excited to be part of the UCSD Biophysics faculty - a unique place.
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RT @DNAmyStrom: Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior. Congratulations Jing! Happy to have cont….
nature.com
Nature Communications - Chromatin heterogeneity in the cell nucleus modulates the size, mobility, and formation of biomolecular condensates; decreasing chromatin heterogeneity correlates with...
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Go Amy!!!!!.
I'm thrilled to announce my next career step-- I’m joining Genentech as a Principal Scientist & Lab Head in Discovery Oncology! .I’ll be hunting new ways to target cancers using my background in disordered nuclear proteins.
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Our tour de force into the nucleolar world — a stunning exploration of spatial organization and the functional choreography of ribosome biogenesis now out in Nature✨ Led by @sofiquinodoz, @jiang_lifei, @brangwynnelab, with theory partners @QiweiYu2,.
nature.com
Nature - Spatially segregated rRNA processing dictates nucleolar morphology and drives outward progression of pre-ribosomal RNA through nucleolar phases.
Now on the Princeton Engineering and ODBI sites, a new mapping tool that allows researchers to peer deep into cells' inner compartments to watch and control ribosome assembly, shedding new light on the machinery responsible for making proteins.
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RT @brangwynnelab: Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing du….
nature.com
Nature - Spatially segregated rRNA processing dictates nucleolar morphology and drives outward progression of pre-ribosomal RNA through nucleolar phases.
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RT @jiang_lifei: So happy to see our work officially out today @Nature on how ribosome biogenesis shapes the multiphase architecture of the….
nature.com
Nature - Spatially segregated rRNA processing dictates nucleolar morphology and drives outward progression of pre-ribosomal RNA through nucleolar phases.
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RT @brangwynnelab: Awesome paper alert! Learn about spectrum of chromatin condensate morphologies due to elastocapillary effects (no, liqui….
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Coupling with reaction-diffusion, we can also do "optogenetic experiments" with these simulations -- local activation of wetting or nonwetting condensates locally recruit or exclude chromatin.
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We can also do shearing on the condensate-network complex. We find that wetting condensates can induce stiffening by an order of magnitude compared to a dry network (i.e. in a pure solvent with no condensates), with implications on interactions between wetting and nonwetting
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Of course we show that our method is identical to the well-known and classical results of elastocapillarity between a single fiber and condensates
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We also systematically studied the interplay between elasticity and capillarity in this phase diagram: when capillary forces overcome elastic forces of the network, droplets become larger, otherwise droplets are confined to pores in the network.
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Another joyful and unparalleled collaboration with the amazing @DNAmyStrom herself during my postdoc at @brangwynnelab and Kosmrlj groups -- we developed a novel computational framework to study elastocapillary interactions between condensates and fiber networks (in this case
If heterochromatin is really a liquid-like condensate, why is it not spherical?. We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments.
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RT @omenndarlingbio: ODBI is seeking a scientific staff member to help run a new microscopy facility. This facility will house roughly a do….
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RT @iAmNarayananLab: We have a postdoctoral opening in the Narayanan Lab ( @UFChemistry @ButlerPolymer. Please app….
narayananlab.com
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RT @lin_shaoting: Join us for our upcoming University-Industry Workshop “High-Throughput Soft Material Development” on May 30th. We expect….
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RT @PhysOfLifeLMU: New in Nature Physics: In a great collaboration with the Jun Lab at UC San Diego, we demonstrate how Min proteins in E.….
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RT @TheSquishyLab: Time flies when you're having fun: .Congratulations to @CBrowneSciClown, the 2nd student to join our lab (back in 2018),….
christopher-browne.com
The Mess lab studies soft matter and complex fluids in messy settings—where 3D disorder and unsteady forcing can induce nonequilibrium or chaotic dynamics. We use experimental microscopy, combined …
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