
David Vilchez
@TheVilchezLab
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Biologist, Professor @CECAD_ @UniCologne @UKKoeln. We study aging, age-related diseases, stem cell biology and proteostasis. @thevilchezlab.bsky.social
CECAD Cologne, Germany
Joined July 2013
New work from the lab @NatureAging!❄️Lowering body temperature extends #longevity. We find that cold-induced #proteostasis prevents #aging and aggregation of proteins that cause age-related diseases #ALS #HuntingtonDisease in C. elegans and human cells
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Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding! #aging #proteostasis.
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RT @IrinaDudanova: Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotyp….
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Don’t miss this opportunity to join Gabriele’s lab! Exciting science!.
#Job alert! A #postdoc position in my lab @CECAD_ @UniCologne is open until December 1st. We look for: enthusiasm, curiosity, scientific rigour, and a background in protein quality control, lysosome signalling, or the cell cycle. We offer: fully funded position, top European
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Another Nobel Prize for basic research in C. elegans 👏🏼👏🏼👏🏼.
This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans. Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals,
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RT @NobelPrize: This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegan….
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In @elife: Root cap cell corpse clearance limits microbial colonization in Arabidopsis thaliana It was a pleasure to contribute to this work from Alga’s lab @Team_Zuccaro and @neto_flames.
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RT @CECAD_: 🔬 Exciting findings from @TheVilchezLab.in @CellReports! ALS-mutant FUS variants interact with PARP1 & histone H1.2, driving ne….
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Our study shows that ALS-mutant FUS variants interact with PARP1 and histone H1.2, leading to neurodegeneration. However, inhibiting PARylation or reducing H1.2 levels can prevent disease-related changes in human neurons and C. elegans models #ALS.
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This was a titanic effort from Hafiza and the lab @CECAD_ @UniCologne @UKKoeln @CGA_age @EKFStiftung @CellReports.
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New paper from the lab! ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes: #ALS.
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RT @IvanAhelLab: A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for som….
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