David Vilchez
@TheVilchezLab
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Biologist, Professor @CECAD_ @UniCologne @UKKoeln. We study aging, age-related diseases, stem cell biology and proteostasis. @thevilchezlab.bsky.social
CECAD Cologne, Germany
Joined July 2013
New work from the lab @NatureAging!❄️Lowering body temperature extends #longevity. We find that cold-induced #proteostasis prevents #aging and aggregation of proteins that cause age-related diseases #ALS #HuntingtonDisease in C. elegans and human cells
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We have a 4-year postdoc position open in our Research Unit on proteostasis!.The project explores inter-tissue regulation using advanced proteomics approaches. Collaborative & interdisciplinary environment. More details & application here:.
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Excited for the next four years of collaboration on proteostasis research between teams from the University of Cologne, University Hospital of Cologne, and the University of Konstanz.
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Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding! #aging #proteostasis.
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RT @IrinaDudanova: Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotyp….
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Don’t miss this opportunity to join Gabriele’s lab! Exciting science!.
#Job alert! A #postdoc position in my lab @CECAD_ @UniCologne is open until December 1st. We look for: enthusiasm, curiosity, scientific rigour, and a background in protein quality control, lysosome signalling, or the cell cycle. We offer: fully funded position, top European
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Another Nobel Prize for basic research in C. elegans 👏🏼👏🏼👏🏼.
This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans. Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals,
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RT @NobelPrize: This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegan….
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In @elife: Root cap cell corpse clearance limits microbial colonization in Arabidopsis thaliana It was a pleasure to contribute to this work from Alga’s lab @Team_Zuccaro and @neto_flames.
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RT @CECAD_: 🔬 Exciting findings from @TheVilchezLab.in @CellReports! ALS-mutant FUS variants interact with PARP1 & histone H1.2, driving ne….
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Our study shows that ALS-mutant FUS variants interact with PARP1 and histone H1.2, leading to neurodegeneration. However, inhibiting PARylation or reducing H1.2 levels can prevent disease-related changes in human neurons and C. elegans models #ALS.
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This was a titanic effort from Hafiza and the lab @CECAD_ @UniCologne @UKKoeln @CGA_age @EKFStiftung @CellReports.
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New paper from the lab! ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes: #ALS.
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We have a postdoc/lab manager position available in our lab. The position is initially until December 2025 with the possibility to be extended until December 2032. If interested, please contact me or apply here:
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The contract is initially for 2 years with the possibility to be extended for at least 2 more years.
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We are looking for a motivated postdoc to study the links between aging and amyotrophic lateral sclerosis. The project combines disease modeling using patient-derived iPSCs and C. elegans models. Please apply here or contact me:
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RT @IvanAhelLab: A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for som….
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