Women in TPD & Induced Proximity
@WomenInTPD
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Joined April 2023
RT @XinGu0317: Super grateful for the generous support from Esther A. & Joseph Klingenstein Fund! We are excited to make more discoveries u….
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RT @thewoolab: Check out our lab's newest pub, live in ACS ChemBio! We report interesting CRBN-independent activities of N-alkylated lenali….
pubs.acs.org
Lenalidomide is a thalidomide derivative that engages the E3 ligase substrate receptor cereblon (CRBN) to promote targeted protein degradation. Lenalidomide possesses a glutarimide moiety, which is...
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Don't have a binder to your favorite E3 yet - no problem! Congratulations to lead author Yunan Zheng and colleagues at AbbVie on their work using non-canonical amino acids in E3s which can be linked via click chemistry to a target binder.
pubs.acs.org
A major challenge in evaluating the suitability of ∼700 known and putative E3 ligases for target protein degradation (TPD) is the lack of ligase-specific binders. Here, we use genetic code expansion...
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New preprint out led by Patricia Blanco-Gabella and colleagues at Univ. of Barcelona looking at how hydrogen bond interactions can stabilize ternary complexes and be better predicted computationally to enable more rational design.
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Don't miss this new journal club issue and great cover photo @ales_salerno!.
Such a great issue of this month’s CeTPD Journal Club—and not just because I’m on the cover 👀 Catch up on the latest TPD publications and give it a read.
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RT @danetteldaniels: Fantastic day in New Haven at the Yale Innovation Summit! Fun times with friends and great TPD panel discussing all th….
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A look at the next generation PROTACs from the laboratory of Anne Sophie Voisen-Chiret at University of Caen Normandy!.
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New thought piece and review co-led by Clara Inghelram from FMI Basel on how shifting affinity of weak interactions with E3 ligases with molecular glues can ultimately lead to robust degradation.
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RT @kdonovan1008: Excited to be hosting next week’s DFCI TPD seminar! We’ll hear from two outstanding speakers, Rebecca Metivier and Martin….
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New preprint of expanded covalent DCAF16 binders that allow for improved degradation of neosubstrates and engage two different cysteines. Congratulations to lead author Lauren Orr and colleagues at UC Berkeley! .
biorxiv.org
Targeted protein degradation (TPD) is a powerful strategy for targeting and eliminating disease-causing proteins. While heterobifunctional Proteolysis-Targeting Chimeras (PROTACs) are more modular,...
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Congratulations to co-author @valspiteri and colleagues at CeTPD @dundeeuni and CeMM on this comprehensive review on degraders, their use in oncology, and future disease indication opportunities.
nature.com
Nature Reviews Cancer - Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. In this Review, Hinterndorfer et al. outline the mechanistic bases of TPD and...
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New review from authors Annabel Cardno, Bryony Kennedy, and Catherine Lindon from University of Cambridge comes a review of the important cellular aspects to consider for obtaining optimal degrader activity!
nature.com
Communications Biology - This review discusses the cellular pathways mediating Targeted Protein Degradation approaches and points to some gaps in our understanding of the biology of novel...
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New preprint out from the lab of @CherylArrowsmi1 and colleagues at University of Toronto and SGC comes ProtacID, a BioID approach to understand both the productive and non-productive interactors of degraders.
biorxiv.org
Here we describe ProtacID, a flexible BioID (proximity-dependent biotinylation)-based approach to identify PROTAC-proximal proteins in living cells. ProtacID analysis of VHL- and CRBN-recruiting...
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Excellent Spotlight article by @CrisMayorRuiz and colleagues on molecular glue mimicry!.
Mutations that stick: Unexpected discovery of molecular glue mimicry
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RT @thewoolab: Our favourite E3 ligase adapter Cereblon is in the spotlight with our newest review by Wenqing! Check it out now and learn a….
pubs.acs.org
ConspectusThe E3 ligase substrate adapter cereblon (CRBN) has garnered widespread interest from the research laboratory to the clinic. CRBN was first discovered for its association with neurological...
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Congratulations @WenqingXu1997 and @thewoolab!!! Such a valuable review and resource for the community!.
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Congratulations @InesForrest!!!.
🚨 Beyond thrilled to share that my PhD work is now available as a BioRxiv pre-print! 🥳 A huge thank you to my amazing colleagues, mentors, and collaborators at @scrippsresearch and @abbvie who supported and contributed to this project!.
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RT @SadiyaTanga: Grateful to have our work featured in RSC’s 2025 International Women’s Day Collection. Grateful for the guidance of my sup….
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