Kun Zhang
@KunZhangBioE
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Bioengineering professor at UCSD; Principal Investigator at Altos Labs
San Diego, CA
Joined January 2022
RT @NatureBiotech: Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation .
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RT @ThoreG: What if the blueprint for youth is never truly lost, just inaccessible?.Today, we're excited to announce the publication of our….
nature.com
Cell Research - Escaping ageing through Cell Annealing—a phenomenological model
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RT @DengYanxiang: DNA methylation goes spatial! Introducing Spatial-DMT: a technology that co-profiles DNA methylation and transcriptome in….
biorxiv.org
The spatial resolution of omics dynamics is fundamental to understanding tissue biology. Spatial profiling of DNA methylation, which is a canonical epigenetic mark extensively implicated in transcr...
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Happy to share our results on the largest multi-modal lung cell atlas, resulting from the HuBMAP lung cell mapping center:
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This is pretty cool, a creative use of AI.
I am organizing a seminar/conference + recruiting speakers. In this blog post, I walk through how I use #AI to augment my intelligence in identifying diverse speakers (+ prevent manels). Try it out yourself: #AcademicTwitter #DEI #Rstats #creativecoding
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RT @rafeequemavoor: Free scientific illustrations for biologists! 😍. @NIH has released a library of 500+ free scientific illustrations to….
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RT @ucsdbe: 🔬💔Discovery of a novel mechanism of cardiac inflammation that may expand therapeutic opportunities from our very own Dr. Kevin….
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RT @ucsdbe: 🔬✨ Congrats to Kian Kalhor, nominated by Dr. Kun Zhang, for receiving the 2023-2024 Engelson Ph.D. Thesis Award! . To learn mor….
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PDACatch, a NGS DNA methylation test for pancreatic cancer, received the FDA Breakthrough Device Designation in 2023, and is currently being offered as a Laboratory Developed Test in the US through Singlera's clinical partner BT Genomics:
btreveal.com
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HepaAiQ, another DNA methylation-based test for liver cancer developed by Singlera, has shown very strong performance on clinical samples in a publication came out this week:
onlinelibrary.wiley.com
The HepaAiQ assay integrates the most effective HCC-specific methylation biomarkers using multilocus quantitative PCR. In multicentre studies, the HepaAiQ model accurately distinguishes HCC from...
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In addition to early screening, ColonAiQ was also found effective in monitoring relapses after surgery:
jamanetwork.com
This cohort study investigates the effectiveness of circulating tumor DNA methylation in early detection of colorectal cancer recurrence.
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In 2014 I co-founded Singlera Genomics with several partners. In 2024 a blood-based methylation test for colon cancer, ColonAiQ, received the Chinese FDA approval. Congratulations to the team who developed the test, took it through the approval, and ran it on 200k+ patients.
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RT @RayDalio: For the most part, life gives you so many decisions to make and so many opportunities to recover from your mistakes that, if….
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Our spatial RNA mapping method is out. We first conceived the idea more than 10 years ago:
link.springer.com
Nature Communications - Application of multiplexed RNA in situ mapping techniques to human tissues remains challenging. Here, the authors report DART-FISH, a padlock probe-based technology capable...
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RT @JShendure: Our latest out today in @Nature. We profiled 12 million single cells from mouse embryos spanning gastrulation to birth, defi….
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RT @AdamEnglerUCSD: .@UCSDJacobs and @ucsdbe's Biotechnology & Bioinformatics undergraduate majors are ranked #2 by.@usnews! Thanks to all….
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RT @AdamEnglerUCSD: So proud that @UCSDJacobs and @ucsdbe's Bioengineering #undergraduate major is ranked #8 by.@usnews! 3 TOP 10 DEGREES i….
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What a fun annual BBQ party for the Zhang lab at sunny La Jolla. Happy to see a few new faces, including @RArgelaguet from Cambridge UK. We had a few new games as well!
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