This week in @JACCJournals we show that Lp(a) particles carry 5x more risk than non-Lp(a) apoB particles (e.g. LDL) In most untreated pts, the much higher concentration of LDL particles remains the 1* target, but benefit of Lp(a) lowering may be > 2nd/3rd add-on LDL therapies

In this study, NT-proBNP and hsTnT were associated with MACE in patients with T2D at high risk of atherosclerotic events, and in individuals with high levels of both biomarkers, dapagliflozin was associated with reduced MACE event rates.

Just in time to listen as you travel to New Orleans, the premiere episode of the TIMI Talks podcast has just dropped! @marstonMD and @ddbergMD introduce the podcast and highlight some exciting presentations at #ACC23 to look forward to. https://t.co/NLsnzfZHHr

New @JAMACardio pub from @MarstonMD, @jpirruccello, @giorgio_melloni, et al 1) CAD PRS has greatest predictive power in younger adults 2) Up to 30% of early MI can be attributed to polygenic risk 3) CAD PRS can help guide statin initiation in 1* prev https://t.co/ocUCAOTmkC

Great to see our work from the CARDIoGRAMplusC4D Consortium on the genetics of coronary artery disease finally out in Nature Genetics https://t.co/CpXaNAdpny A short 🧵 to highlight some key findings..... 1/8

Scientists discovered 68 new genome sites linked to risk for heart disease and pioneered an exhaustive approach to find underlying causal genes, with a framework that could enhance genome-wide association studies on other diseases. https://t.co/8zmvouN29I

🚨 Is there a role for serial assessment of high-sensitivity #troponin in *STABLE* patients with a recent ACS? New analysis from IMPROVE-IT @TIMIStudyGroup now in @JAMACardio https://t.co/C4QwLY1xuS @AqamarMD @rgiugliano @marstonMD @cpcannon

Excited to share our whole genome sequencing analysis of lipids in @nih_nhlbi TOPMed led by @MargaretSunitha & with @gina_peloso! https://t.co/2BrKnBawBc @NatureComms [1/10]

Just out! 📢 📢 📢 The largest study on stroke genetics 🧬 with more than 2M individuals (incl. >200,000 cases) just published in @Nature! Have a look here 👉 https://t.co/narkzZwWp9 🧵1/7

Live from Milan @ #EASCongress2022: Just presented LBCT data from TRANSLATE-TIMI 70 Max intracellular ANGPTL3 inhibition with antisense oligonucleotide Vupanorsen resulted in: >80%⬇️in VLDL-C >60%⬇️in Remnant-C >60%⬇️in TGs ⬆️in liver fat @ higher doses = more work to be done

Our latest genetics study out of @TIMIStudyGroup now published in #EHJ just in time for @escardio. Co-led by star BWH fellow @AmandaGarfinkel and a huge team effort as always from @KamanuFred, @Giorgio_Melloni, & @broadinstitute colleagues @steven_lubitz, @patrick_ellinor, & more

Put together a quick demo nb on how to use the native categorical feature support in HistGradientBoostingClassifier, XGBoost, LightGBM, and CatBoost to finish up the gradient boosting lecture tomrw. Still really like the HistGradientBoostingClassifier :)

Operating on multiple columns in a row-wise manner is fairly straightforward in {dplyr} 📦. In this workflow, the {c_across} function allows you to use the tidy selection syntax to select columns to operate on 🔍 https://t.co/gmFEid0WDK #rstats #DataScience

Thanks @Circ_Gen for highlighting our publication w/ this excellent video summary! Much more effective than my usual Twitter thread! As always, this was a huge team effort by many @TIMIStudyGroup and @BroadInstitute, including GM, @patrick_ellinor @steven_lubitz, MSS, & CTR

Today in @CircAHA: A 32-SNP genetic risk score predicts ischemic stroke in subjects across 5 TIMI trials. @PNPatelMD @marstonMD #AHA20

In subjects who already have cardiometabolic disease, does a genetic predisposition still play a role in risk for ischemic stroke? Excited to share at #AHA20 – our team effort by @marstonMD, @KamanuFred, @TIMIStudyGroup, and many others (w/ simultaneous pub in @CircAHA) 1/n

Single-cell transcriptomics identifies two previously undescribed cardiac fibroblast populations that are key drivers of cardiac fibrosis https://t.co/d8CzDBpMNV #AHAJournals @Alex_R_Pinto @genomequant @pinto_lab @BakerResearchAu @jacksonlab @PAM_latrobe

TIMI is very proud to welcome Nicholas Marston and David Berg on as TIMI Investigators. @marstonMD @ddbergMD

Blog post: lessons learned from 5 years of not finding a small molecule that binds PrP. Pay attention to pipelines, PAINS, platforms, pivots, and priorities.