Congrats to the @MGHCVFellows Team for winning tonight’s @ACCMass FIT Jeopardy! Onward to #ACC24 in Atlanta! @md_harrington @ddefariayeh

The fellows had the honor of meeting with @NMHheartdoc before Cardiology Grand Rounds - CPC yesterday. Great advice and a fantastic case! @JHaimovichMD @SeanMurphyMBBCh @OliviaHulme_MD @WLimpitikul @Difeldman4 @PNelsonHsieh @mchilazi @PNPatelMD @RachGoldB

Congrats to everyone who matched today from our first year fellows! @OhadOrenMD @OliviaHulme_MD @WLimpitikul @tigerstatdoc @annaokellymd @PNPatelMD @SeanMurphyMBBCh @GiselleSA_MDPhD

Go Christy! @clmarcaccio @BidmcCvi @BIDMCSurgery

Big thanks to my teachers and coaches @mghecho for taking the time to train me on my four week rotation. We @MGHCVFellows are just trying to be an extension of them on nights and weekends!

Hats off to @PNPatelMD for crushing it on one of his first echo calls this weekend and uncovering this unexpected finding for a patient with an inferior STEMI! #cardiotwitter

⚡Now online from the Seidman lab of @harvardmed: Contribution of Non-Canonical Splice Variants to TTNtv #Cardiomyopathy https://t.co/gaBAtRJ9Kj @AHAScience #AHAjournals #CardioGen 📽️@JeanetteErdmann @AnwarChahal

First and foremost, endlessly grateful to Kricket, Jon, the Seidman Lab, our collaborators, and @SarnoffCardio. But many others to thank, including @BrighamMedRes @MGHCVFellows @saptarsi_haldar @jonepstein1 @chaz_hong @tmmichelangelo @JenHoCardiology. It takes a village. (6/6)

Conclusions: Splice-altering variants affecting non-canonical positions in TTN explain 2% of DCM and offer a 10-20% increase in the diagnostic power of TTN sequencing in this disease. Trends in data suggest rules that may improve detection of similar variants in other genes.

Key findings: 1⃣ Splice altering VUS in TTN were present in 2% of DCM cases (0.2% of controls) 2⃣ 20% of VUS in TTN splice regions affect splicing and are unrecognized pathogenic variants 3⃣ +5 position in donor site, -3 position in acceptor site most commonly affected

We studied rare variants of unknown significance (VUS) located in the splice regions of highly expressed TTN exons from: ➡️203 DCM cases ➡️3329 normal subjects, and ➡️clinical variant databases The effects of these variants on splicing were assessed using a minigene assay.

TTN truncating variants (TTNtv) are the leading genetic cause of idiopathic DCM. But patients undergoing genetic 🧬testing are found to have synonymous, missense, or intronic variants in splice regions of the TTN . How many of these affect splicing and are unrecognized TTNtv?

Excited to share work initially started with the support of @SarnoffCardio 👇 Now out in @Circ_Gen. Awesome visual abstract by @JeanetteErdmann & @AnwarChahal! Full study here: https://t.co/fJMCwgD18p. Quick summary below:

🙌congrats to our first-year fellows for crushing their first week!💖 @ohadoren @PNPatelMD @OliviaHulme_MD @annaokellymd @tigerstatdoc @SeanMurphyMBBCh @GiselleSA_MDPhD Wora

💡non-CV🏥= window of opportunity for GDMT optimization 👉strategy to optimize GDMT utilizing a virtual team of cardiology-trained physicians 📌BB↗️72%➡️88% 📌ARNI↗️6%➡️17% 📌MRA↗️16%➡️29% 📌3️⃣💊↗️9%➡️26% ⚠️Virtual GDMT Team=improve HF💊optimization @secardiologia

Each yr pts with HF in 🇺🇸 experience: 1M primary 🏥 for acute HF >3M secondary🏥 for other conditions #IMPLEMENTHF in #EJHF: feasibility of #GDMT optimization during these "secondary" admits Led by stars @ankeetbhatt & @SunnyVMD in collab w #BWHPharmacy https://t.co/h6ae8uz7eE

Why were LDL targets lowered over time? @PNPatelMD and @rgiugliano review evidence behind the "lowest is best” hypothesis and options to get patients to goal. https://t.co/tflaZav0qv

Check out 👇 this educational resource we initially made for the @BrighamMedRes Cardiology B teams 🫀(@emilyswlau & @_brendan_'s idea!), now in print for a larger audience. Big thanks to @rgiugliano for the expert insight and guidance!

Across a broad spectrum of subjects with cardiometabolic disease, a novel genetic risk score was a strong, independent predictor of ischemic stroke https://t.co/MHgzTqbRT4 #AHAJournals @marstonMD @PNPatelMD @TIMIStudyGroup

Just so unbelievably thrilled and grateful for the opportinity to join @MGHCVFellows next year! So thankful to my family, friends, and @BrighamMedRes for supporting me to the next step in my journey. Can’t wait to be a part of this incredible group!! @ddefariayeh @OliviaHulme_MD