New publication 🚨 Our RCT + isotope tracing detailing a significant nutrient-nutrient interaction during pregnancy between choline and docosahexaenoic acid (DHA; omega 3) is now online @AJCNutrition. A thread ⬇️ https://t.co/NmSGXwjjHu #RDchat #Metabolism #Obgyn #obstetrics

Already getting DMs with questions from patients and providers about 5-formylTHF/leucovorin & Autism. It's a prescription, the existing response rate in trials is variable and likely depends on dose, timing, folate receptor autoantibody titers, etc. while pts understandably might

I wonder how many supplement companies that ditched folic acid for 5MTHF are now frantically googling suppliers for 5FTHF.

To be clear, the media is already butchering this. It is not 'folate deficiency', it is cerebral folate deficiency. Serum folate and homocysteine biomarkers are typically normal in CFD - you only see reduced folate in cerebrospinal fluid. The cause is autoantibodies against the

I'll be interested to see where this goes - cerebral folate deficiency linked to folate receptor autoantibodies presenting with autism-like symptoms is a very new/small area of research. No population data to say how prevalent of a link it is and no landmark clinical trials that

#1 In a paper just published online in Diabetes, we showed that homozygous loss-of-function mutations in the Glucagon receptor (GCGR) cause early-onset hepatic steatosis in people. DOI: https://t.co/yCFgDDycyU

Despite all the rhetoric from folks amongst the altmed/MAHA crowds who think they're pwning corrupt hospitals and doctors with their anti-establishment health regimens... my group chats with various providers are full of everyone talking about how we've been busier than ever

The recent conversation sparked by the NYT on protein nutrition has missed some major points of discussion needed to understand why numbers for how much protein you need to eat get confidently tossed around but vary so much. 2 major issues: 1. Protein intakes have been

I truly enjoyed this discussion with @RealDoctorMike covering a range of topics on food, nutrition, and metabolism. We also discuss my reasons for leaving @NIH and what’s needed to really improve nutrition science. https://t.co/OK6ysdoUGx

There's a strong chance that RFK Jr looks at kids in the airport and also sees chloroplast dysfunction.

I mean this genuinely and it's important to state it - anti public health folks act like we're defending perfect institutions when everyone I know advocating right now has a long wishlist for how they'd change the way things are done if the political will and funding were there

Amidst all the chaos, I am saddened by how much potential to actually impact nutrition, science funding, rigor & reproducibility, etc is being wasted. Defense against existential threats & fundamentally anti-science sentiments is essential right now but can't distract entirely

Massive walkout underway at CDC. RFK jr. must resign so that we can be safe. #USAnotRFK is our new hashtag on this.

NEW PAPER At recent conferences I still see people reporting "responders" & 'non-responders" often prematurely See our latest paper led by Lorenzo Lolli & Greg Atkinson on how to detect responders & non-responders (treatment response heterogeneity) https://t.co/EuPg9gn8nt

The anger folks feel towards the CDC about nutrition/obesity is wildly misplaced - the CDC has limited federal powers to do much of anything beyond making recs. There have been institutional failures to take obesity and nutrition-related chronic disease. You need only look to

Folks like @gorskon @ScienceBasedMed have been covering this tirelessly for years - it's sad but not at all surprising that we're in this situation

For anyone wondering how we got to the point of an HHS Director who's thinking about children's mitochondria when he looks at them. There are so many academic medical centers complicit in how we got here because embracing the rise of bs integrative & functional medicine helped

Not to leave the dietetics & medicine folks with zero culpability - there is a huge contingent of folks branding themselves as 'integrative and functional ' who cite handwavey, non diagnostic/prognostic markers like mitochondrial function and 'inflammation' all the time to

Real talk - this is a reason basic science programs desperately need to teach students how translation works. If I had a dollar for every time I've sat in lectures or read a grant that handwaves about the role of an organelle or cytokine being a key player in disease or mediating

Metabolic Assessment 101: A) Assess Anthropometrics🟢 B) Assess Dietary Intake🟢 C) Assess Clinical Chemistries 🟢 D) Look at the pediatric patient to diagnose mitochondrial and inflammatory disease 🚫