Dr Rebecca Coll
@Rebecca_Coll
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Lecturer in Immunobiology at QUB - inflammasome, NLRP3, dose response curve, and bad pun enthusiast. Views expressed are mine alone.
Belfast, Northern Ireland
Joined August 2010
Delighted to share that our study with @bioagelabs NLRP3 inhibitors is now online @JExpMed ! Together with @Geyer_lab @benedicte_py and @Innate_immuno we characterise BAL-0028 and BAL-0598. Excited to see the new NLRP3 biology they will reveal!
#NLRP3 is a target for anti-inflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @Rebecca_Coll et al. characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. https://t.co/w1xwgcU8wG
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Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action, from Kevin Wilhelmsen, Rebecca Coll, and colleagues ๐ https://t.co/ecqWtaM6LR ๐ Part of 2025: The Year in Experimental Medicine: https://t.co/mfpD9K2ezf
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Dr Andrew Boyle from @WWIEM_QUB has been awarded a prestigious fellowship to lead a UK-wide intensive care clinical trial. The Efficacy and Mechanism Evaluation Advanced Fellowship from @NIHRresearch recognises researchers demonstrating exceptional promise and leadership in
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While at Guinness, William Sealy Gosset developed a statistical method to infer population means from small samples, minimizing lab work and cost. Since Guinness forbade staff from publishing research, he signed his paper "Student". That's how the Studentโs t-test, one of the
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Congratulations to new Nobel Laureate and AAI Distinguished Fellow Shimon Sakaguchi, co-winner of the 2025 @NobelPrize in Physiology or Medicine for his foundational discoveries on regulatory T cells and peripheral immune tolerance! Published in The JI: https://t.co/FAcszhA6TH.
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Yay Immunology! Tregs FTW!
BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi โfor their discoveries concerning peripheral immune tolerance.โ
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So proud of the new Dr @Emck197 for smashing her PhD viva! Huge thank you to her examiners @BenediktKessler @gunnar_ns for great discussions on NLRP3 inflammasomes and proteomics - first student co-supervised work Prof Ben Collins in the Collins Lab-Coll Lab-Collaboration!
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Delighted to be part of this special collection - some very nice innate immunity studies here!
We are pleased to present a special collection highlighting recent findings in the #InnateImmunity field. It spotlights cutting-edge research on the mechanistic aspects of innate immune signaling upon #infection, in #autoimmunity, & in #neurodegeneration
https://t.co/0GzRUUXEot
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Our 1st year medical students were privileged to hear from members of Road Victim Support Northern Ireland-Donegal ( https://t.co/03ffmQKkuN) today. Please support their campaign Caoimhรฉโs Law: Stop Exploiting Trauma. Itโs NOT Your Story To Tell
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Nice to see our recent study on novel NLRP3 inhibitors with @bioagelabs in @JExpMed highlighted in @NatRevDrugDisc - ๐ฆ๐๐ฅ ๐Overcoming roadblocks to anti-inflammatory NLRP3 inhibitors
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๐จ๐๐๐๐๐ ๐๐๐๐๐๐ ๐
๐๐ ๐๐๐๐ ๐'๐๐๐๐๐๐!!!! She's done it!!!๐คฏKate O'Connor has just won Ireland's first ever global outdoor senior medal in the multi-events with a national record-breaking performance in Tokyo๐ ๐ฅHeptathlon: 6,714 NR She joins an
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๐ข Meet #UIG #FraserSymposium speaker Prof Molly Ingersoll! Joining us from Institut Pasteur, Paris, sheโll speak on mucosal immunity in the bladder at Riddle Hall, Mon 15 Sept. For Event Details: r.coll@qub.ac.uk More Info: https://t.co/eWZ0dz5Qds
@britsocimm #Immunology
research.pasteur.fr
The thematic of our group, within the Dendritic Cell Immunology Unit, is immunology of the bladder with two broad projects focused on the related topics of response to uropathogens and response to...
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Groundbreaking stuff - well done @Rebecca_Coll ! So pleased this amazing study is out now and very grateful we could make a small contribution to testing these novel #NLRP3 #inflammasome inhibitors in primary cells. Looking forward to the ongoing clinical development!
#NLRP3 is a target for anti-inflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @Rebecca_Coll et al. characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. https://t.co/w1xwgcU8wG
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RESEARCH BREAKTHROUGH: Discovery could lead to new drug treatments for #InflammatoryDiseases including #Alzheimers, #asthma, #arthritis and #obesity. Find out more: https://t.co/OzngM61qCK
#LoveQUBResearch @WWIEM_QUB @bioagelabs @MHLSQUB
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Weโre pleased to announce our new publication today in Journal of Experimental Medicine describing the discovery and characterization of the novel class of NLRP3 inhibitors that includes BGE-102, a brain-penetrant, orally available small molecule that BioAge is initially
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Weโre excited to welcome A/Prof Dan Bachovin, of Memorial Sloan Kettering Cancer Centre, who will present on Innate Immune Sensing of the Intracellular Redox State at the UIG Seminar Series. Event details: r.coll@qub.ac.uk โน๏ธ More info: https://t.co/vBQvZmMS3H
@britsocimm
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Step inside an immersive experience to learn about the global threat of antimicrobial resistant infections, how bacteria develop resistance to antibiotics and the research from @wwiem_qub at @QUBelfast to fight it. Where: W5 (1st Floor) 2 Queens Quay Belfast When: 1st-15th Sep
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Had a brilliant couple of days with the lab in Galway at the @Irishimmunology meeting - great science and great craic !!!
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