Very excited to share the latest work from our lab, which was published today in Nature! https://t.co/bopoov16pa PhD graduate and now post-doc @SofiaDahlman, along with co-senior author Sam Forster from The Hudson, and lab members @SubDinesh

Im really excited for this work as it sets up a platform for us to study, characterise, and eventually determine what impacts temperate phages may have on the human gut microbiome. Future work may even allow us to manipulate the gut using these unique viruses.

- Temperate phage biology is HARD. We cant using traditional PFU plating (due to superinfection immunity), most isolates were poly-lysogens, equipment required is expensive and technically limiting, and the methods to study these phage had not been developed.

- We test ten diverse induction agents, and the most surprising one was that human cellular lysis products were strong inducers of temperate phages, suggestive of a mechanistic link between gastrointestinal cell lysis/inflammation and the gut virome.

A couple of highlights from the paper: - We find >100 new bacteriophages, many of which had never been isolated before and we're only 'discovered' through metagenomic sequencing approaches.

This was a really challenging study where we attempted to characterise the biology of hundreds of temperate bacteriophages from the human gut - in the lab! This required anaerobic chambers to grow the gut bacteria, entirely new methods to induce and study the bacteriophages.

This hospital-specific phage cocktail can be replicated across many institutions and pathogens, and we hope it will improve treatment outcomes for patients suffering from these multidrug-resistant bacterial pathogens.

We believe this approach offers a strong middle-ground between personalised phage therapy and broader spectrum antimicrobial agents.

In this work, we developed, for the first time, a phage cocktail personalised to a hospital's multidrug-resistant pathogen profile. This product, which we call Entelli-02, offers a frontline treatment option against Enterobacter infections that are resistant to most antibiotics.

Excited to announce the latest research published by our lab, which is led by Dinesh Subedi @SubDinesh and is out today in Nature Microbiology @NatureMicrobiol https://t.co/5U3e1Nli1a

Time to register for the spectacular new conference on Bacteriophage Biology, Dynamics and Therapy! Oct 12-14. Washington DC. Go to: https://t.co/f1d42CdURt. #phage #phagetherapy

Out Now! The T-series bacteriophages are reductionist models that continue to shape the field https://t.co/G3RLgr4FYy #Microbiology #Bacteriophages #TseriesPhages

The T-series bacteriophages have impacted my career and are microbes our lab's research continues to use as model organisms. You can read more as part of @NatureMicrobiol 'Microbes Matter' series below: https://t.co/jmUQ8JPVpp

Dive into our lab’s first peer-reviewed publication—co-led with our friends @ben_a_adler and Muntathar Al-Shimary from the Doudna lab! If you’ve already read the preprint, don’t miss the new updates: https://t.co/gNIbc6e3li @NatureMicrobiol

Our lab was featured on the RRR Radio show @einstein_agogo to talk about recent phage research and its application to treat antibiotic-resistant infections Have a listen! https://t.co/tR3pksaSy1 @NandoGordillo Natasha Smith @DrShaneRRR

Nature News piece on the hidden players of the gut microbiome (hint, they're phages, of course) “Our virome is hugely abundant and incredibly diverse, and we’ve looked at just a tiny percentage,” https://t.co/34DeKqF2DZ

👏Congratulations to the VICPhage team on such an amazing achievement! VICPhage is a bench-to-bedside initiative involving #phage research & clinical product development at the Monash Phage Foundry, with phage therapy administered by the clinical team at The Alfred Hospital! #AMR

The Award for Research Engagement and Impact goes to the VICPhage team (@JeremyJBarr, @AntonPeleg, @NandoGordillo, @SubDinesh). Their impactful work was showcased in @SBS doco 'Last Chance to Save a Life' 👏👏 Learn more about the #MonashScienceAwards 👉 https://t.co/1JXxaMqFCR

How are phages cleared from the bloodstream? We learned that serum factors but not neutrophils help clear phages. Thanks to Rob McBride and our terrific team of collaborators. https://t.co/K10wUwg96S

This weekend @stephh_lynch represented @PhageAustralia at #SanDiego International Film Festival discussing our #phagetherapy initiatives & showcasing @Emma_WattsTV @SBS documentary - "Last chance to save a live" in 🇦🇺 @Iredell_Lab treated his first patient with #phage in 2007.