Marc Erhardt
@Salmo_Lab
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Bacterial geneticist @HumboldtUni studying assembly and function of a fascinating nanomachine - the bacterial flagellum
Berlin, Germany
Joined December 2016
Interested in anti-bacteriophage defense systems? We have an open PhD position in cell biology of bacteria and bacteriophages: https://t.co/3eREu4mA0E
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A beautiful example of evolutionary innovation: Bacterial chemoreceptor was "reprogrammed" in pathogenic E. coli to control expression of flagellar genes instead of signalling through the chemotaxis pathway.
embopress.org
imageimageChemotaxis receptors typically mediate biased movement of motile bacteria in environmental gradients by controlling rotation of the flagellar motor. This study identifies a chemotaxis...
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Out Now! The structure of the complete extracellular bacterial flagellum reveals the mechanism of flagellin incorporation https://t.co/bRmSe5N9JK
#Microbiology #Bacteria #Flagellum
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"The structure of the complete extracellular bacterial flagellum reveals the mechanism of flagellin incorporation" Now published @NatureMicrobiol 🥳! https://t.co/CuyIhKmQxj
I'm excited to share the newest preprint of the lab... the structure of the complete extracellular flagellum, our most favourite bacterial nanomachine! https://t.co/fR8EhAdntY A result of a very productive collaboration with @BergeronLab and @BeebyLab !
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Cold Spring Harbor Laboratory - absolutely humbled by the beauty of this place and the ubiquitous spirit of the Delbrück "phage group" era 🧬🌊🦪
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Exited to share our preprint on the structure of a Salmonella contractile injection system 🥳 Wonderful work by first author @Rooshanie Ejaz and @CloudyKielkopf, @freddie__martin, @HangryHobbit, @RebrovaEva, great collab with @Salmo_Lab
@UCPH_CPR #cryoem
https://t.co/rKTXTFPFgj
biorxiv.org
Extracellular contractile injection systems (eCISs) are phage-derived nanomachines used by bacteria to deliver effectors into target cells. Well-studied examples include the Photorhabdus asymbiotica...
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And here it is, the completed BASEL collection finally published as early access in @PLOSBiology - see the thread for more details. 🤗🧬🎣
🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵
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Now published @PNASNews 🥳 Bacterial motility depends on a critical flagellum length and energy-optimized assembly | PNAS https://t.co/fCC0cVSPzS
pnas.org
The flagellum is the most complex macromolecular structure known in bacteria and is composed of around two dozen distinct proteins. The main buildi...
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Join us and @Salmo_Lab to explore phage-bacteria interactions, with a strong focus on microscopy techniques. Looking for a motivated PhD student! 🔬 Interested? Apply here 👉 [ https://t.co/onC4QTN6ME] 🔄 Please re-share to spread the word!
nature.com
Join our PhD project on anti-phage defense systems at Humboldt-Universität Berlin to uncover bacterial immunity with cutting-edge imaging and genetics
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With @jrpenades, we challenged AI co-scientist @GoogleAI to generate hypotheses. In just 2 days, it recapitulated our unpublished, experimentally confirmed mechanism for how cf-PICIs spread between bacterial species! 🤯 @imperialcollege @FlemingCentre
https://t.co/hXkZZco6vu
biorxiv.org
AI models have been proposed for hypothesis generation, but testing their ability to drive high-impact research is challenging, since an AI-generated hypothesis can take decades to validate. Here, we...
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Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems Congrats @TanaWein! Thanks Kranzusch lab! https://t.co/yWUj5ZMjjO
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Internationales Forschungsteam beschreibt erstmals die Struktur und Funktionsweise des Zorya-Systems, eines hochspezialisierten antiviralen Schutzmechanismus gegen Bakterien https://t.co/kfoC3tbPHK
@Salmo_Lab @__jphilipp Bild: Frederick J.O. Martin/ Universität Kopenhagen
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🦠Neues bakterielles #Immunsystem entschlüsselt: Ein internationales Forschungsteam um @Salmo_Lab & @__jphilipp der #HumboldtUni beschreibt nun erstmals die #Struktur und #Funktionsweise des Zorya-Systems in der Fachzeitschrift @Nature! Mehr Infos 👉 https://t.co/6A5YlweOlK
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Thrilled to share that our collaborative work, led brilliantly by @HaidaiHu, is now published in @Nature! Huge thanks to the incredible @NMITaylorLab team - it was a joy to work with you. Grateful to @Salmo_Lab, @SimonJacksonNZ, and @AHarms485 for their invaluable contributions!
Very happy our paper on Zorya anti-phage defense system is now published in @Nature! 🥳 Big congrats to first authors @HaidaiHu and @__jphilipp and all other authors! Wonderful collab with @Salmo_Lab and @SimonJacksonNZ #cryoEM @UCPH_CPR @koebenhavns_uni
https://t.co/AFPSKH14Za
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Our work describing the structure and mechanism of the Zorya anti-phage defense system is finally out @Nature! Led by @HaidaiHu and @__jphilipp in a wonderful collaboration with @NMITaylorLab, @SimonJacksonNZ, @AHarms485 et al.! https://t.co/xCXVEqfJv3
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Evolutionary necessity for immune innovation harnessed components of the bacterial flagellar motor into a wild defense system - Zorya One of the most intriguing and sophisticated bacterial defense systems out there Congratulations Nicholas Taylor and colleagues!
Very happy our paper on Zorya anti-phage defense system is now published in @Nature! 🥳 Big congrats to first authors @HaidaiHu and @__jphilipp and all other authors! Wonderful collab with @Salmo_Lab and @SimonJacksonNZ #cryoEM @UCPH_CPR @koebenhavns_uni
https://t.co/AFPSKH14Za
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Beautiful work on a crazy anti-phage system!
Very happy our paper on Zorya anti-phage defense system is now published in @Nature! 🥳 Big congrats to first authors @HaidaiHu and @__jphilipp and all other authors! Wonderful collab with @Salmo_Lab and @SimonJacksonNZ #cryoEM @UCPH_CPR @koebenhavns_uni
https://t.co/AFPSKH14Za
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Thrilled to share that our Zorya paper is now published online in Nature! It was an incredible team effort @__jphilipp @Salmo_Lab @SimonJacksonNZ —thank you to everyone who contributed to this work.@IngaTrails @VKleinSousa @AritzRoa @freddie__martin @yongwangKU @AHarms485 @others
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Very happy our paper on Zorya anti-phage defense system is now published in @Nature! 🥳 Big congrats to first authors @HaidaiHu and @__jphilipp and all other authors! Wonderful collab with @Salmo_Lab and @SimonJacksonNZ #cryoEM @UCPH_CPR @koebenhavns_uni
https://t.co/AFPSKH14Za
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Bacterial small RNA makes a big impact for gut colonization Monzel & Desai @LIH_Luxembourg highlight work of @MoualiYoussef @StrowigLab IDing SrcF, sRNA from S. copri that promotes colonization by regulating bacterial degradation of dietary carbohydrates https://t.co/g9eGCrWuts
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