🎉 Excited to share my PhD work's preprint on ABPP of Klebsiella pneumoniae hydrolases! Identified 10 serine hydrolases, spotlighting new anti-virulence targets! Huge thanks to everyone involved, especially @ChristianSLentz😌Great collaboration! @CANS https://t.co/z7VpuZO8lO

Large-scale CRISPR screening in primary human 3D gastric organoids enables comprehensive dissection of gene-drug interactions | Nature Communications

Congrats to postdoc @ZheZhou_ICA on her paper out today in @cellhostmicrobe showing that gut bacteria cross-feed a common dietary antioxidant to produce energy under anaerobic conditions. Big thanks to collaborators Angela Jiang and Xiaofang Jiang @NIH. https://t.co/T7WYvRooD4

Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work by @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. https://t.co/D0zrFe95Hz

Featured Article: Microbiota changes with CRC tumor location Fecal microbial changes in proximal vs distal CRC w/specific microbes linked to tumor location. Multi-cohort analysis demonstrates diagnostic potential of location-specific fecal bacteria in CRC https://t.co/dXXktNwbtG

Scientists from Peking University (@PKU1898) developed a microinjection-based method to quantify the growth time-dependent nonlinear elasticity of intestinal #organoids. 🧫 💡Learn more about their research: https://t.co/KrZOOl9xl1

Breakthroughs in medicine start with research — and lead to better lives. Ask Dr. Kevan Herold of Yale School of Medicine. His team’s work led to approval of the first drug able to delay the onset of Type 1 diabetes. He’s seen firsthand the profound effects on young patients

https://t.co/vJR8j2gdD2

📢 New in @NatureComms! Researchers at the University of Hong Kong developed human #RespiratoryOrganoids that reproducibly propagated human rhinovirus C to characterize the virus-host interaction. 🦠 Learn more: https://t.co/Nj1pXxmKKw

Featured Article: C. jejuni promotes CRC metastasis CRC tumors enriched with Campylobacter, whose production of genotoxin accelerates tumor metastasis, offering insight into the role bacteria play in metastasis https://t.co/poAMXlsS7q

A 3-year postdoctoral position in antiphage immunity hosted by my lab (Lund), co-supervised @gem__atkinson (co-PI, structural bioinformatics, @lunduniversity) and Pontus Gourdon (co-PI, cryo-EM, Lund University and @uni_copenhagen). PleaseRT!

Interesting paper by the group of Rui Wang in Analytical Chemistry. They systematically studied several activated esters with heteroaromatics in the leaving group and show strong, tunable lysine labeling with high hydrolytic stability. #ChemBio

Great to see them apply the proteome-wide profiling method for electrophile reactivity and selectivity that we developed together with @nesvilab in Fragpipe in this exciting system.

Interesting @ChemRxiv preprint by the group of @ThomasBPoulsen with first author @EsbenSv. They used OxSTEF probes to study proteins with N-terminal cysteines in the proteome and specifically investigated difference in normoxia and hypoxia.

REVIEW @ScienceMagazine Chemical genetic approaches to dissect microbiota mechanisms in health and disease https://t.co/9ov2jkmRns

Check out this preview of the @cellhostmicrobe paper from the @StrowigLab in collaboration with #HIRI's @JoergLab. ⬇️

Interesting paper by the group of @MichaelBollong of @scrippsresearch in @J_A_C_S. A high-throughput assay for cysteine-reactive electrophiles based on luciferase activity allows identification of azetidinyl oxadiazoles as cysteine-reactive electrophiles. https://t.co/CyD25dBXIR

Check out this new paper from the Sander van Kasteren and @derozenleiden labs @LED3hub. Labeling of newly synthesized proteins with BONCAT identifies up- and downregulated proteins in S. aureus persisters. Very happy that we could make a small contribution

Tomo Mizutani & Matteo Boretto selected 4 spontaneous colon #cancer mutations by sequential withdrawal of growth factors from mismatch repair-deficient #organoids. Mutations resemble those of Lynch syndrome & MSI-H patients tumors. https://t.co/FKokUczHGk

Out now in @ScienceAdvances: Antibiotics damage the colonic mucus barrier in a microbiota-independent manner @Mucus_Man @meytaln https://t.co/1Smbg5Qq99

1) Excited to share a ms entitled: Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D #organoid sheets. It describes an alternative to #Matrigel https://t.co/97jLdmRYHe A thread: