Hite Lab
@HiteLabMSKCC
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Richard Hite Lab at @MSKCancerCenter Twitter account run by Hite Lab members
New York
Joined March 2021
RT @lydfinley: OK, I’ll bite. We, as scientists, believe our work has value to society. Enough value that we ask for funding from taxpayers….
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RT @TheCHLeeLab: Our work on human urate transporter is out @cell_res. @YaxinDai.single-handedly drove this project, which revealed the tra….
nature.com
Cell Research - Transport mechanism and structural pharmacology of human urate transporter URAT1
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RT @CellPressNews: Metabolic regulation of the hallmarks of stem cell biology by Jackson (@__btjackson) and Finley (@lydfinley). https://t.c….
cell.com
In recent decades, metabolic adaptations emerged as a mechanism by which pluripotent and tissue stem cell fate decisions are regulated. In this review, Jackson and Finley describe the common themes...
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RT @KivancBirsoy: New work from our lab’s genomics guru @ArtemAKhan with @egamazon. Artem generated a new platform for metabolic gene disco….
nature.com
Nature Genetics - This study presents a multiomic Gene–Metabolite Association Prediction (GeneMAP) platform for discovery of metabolic gene function and identifies SLC25A48 as a mediator of...
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RT @Yeeun_Jecy_Son: Very grateful to give a webinar for BRIC on June 18th Tuesday, 11am KST (or June 17th Monday 10pm EST!) about my recent….
ibric.org
포유류 세포 생체막을 이루는 다양한 인지질 중 가장 풍부한 두 가지 인지질인 phosphatidycholine과 phospha...
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RT @lydfinley: Our newest preprint identifies a role for p53 in balancing nutrient supply and demand by enabling phospholipid headgroup rec….
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RT @Yeeun_Jecy_Son: Very grateful that I am invited to give a webinar for ASBMB Lipid Research Division on May 29th, 12-1pm EST. You can re….
asbmb.org
May 29, 2024
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RT @JiSunLab: Our collaboration with @WillPPK on NOX5 is out. We captured NOX5 in different activation states, and used MD simulation to ex….
nature.com
Nature Communications - NADPH oxidase 5 (NOX5) is activated by Ca2+ signaling, catalyzing superoxide production by transferring electrons from intracellular NADPH to extracellular oxygen. Here the...
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RT @Nature: Nature research paper: Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1
nature.com
Nature - A structural, biochemical and metabolomic analysis reveals the mechanistic basis for transport of extracellular choline and ethanolamine into cells by the human transport protein FLVCR1.
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RT @lydfinley: Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1 @nature .Congratulations….
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RT @Yeeun_Jecy_Son: Excited to share our study on a high-affinity choline and ethanolamine transporter, FLVCR1, published today at Nature.….
nature.com
Nature - A structural, biochemical and metabolomic analysis reveals the mechanistic basis for transport of extracellular choline and ethanolamine into cells by the human transport protein FLVCR1.
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Full text link: Congratulations to all of the authors and to @RosemaryJCater @pippomancia and colleagues for their identification of the related FLVCR2 as the blood brain barrier choline transporter, published along side our paper @Nature.
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Structures of choline- and ethanolamine-bound FLVCR1 revealed that the metabolites differentially bind to a common transport site, which enabled identification of mutants that uncouple choline and ethanolamine transport.
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In this study, Jecy identified that in addition to being responsible for the uptake of choline, FLVCR1 is also responsible for the uptake of ethanolamine into cells, where it fuels the biosynthesis of the two major lipids in mammals - PC and PE.
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Excited to share our recent study Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1 published this week @Nature led by amazing @Yeeun_Jecy_Son in collaboration with @TimCKenny @ArtemAKhan @KivancBirsoy .@MSKCancerCenter .
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RT @NatureComms: Authors from @MSKCancerCenter: @HiteLabMSKCC, @labnavid and @VinaySapuru report structures of IP3 receptor with insights i….
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Congratulations James! Well deserved.
BREAKING: Congratulations to now Associate Professor James Letts @LettsScience for his promotion with tenure. @ucdavis is lucky in having you on the faculty.
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Exciting work from @TimCKenny and @KivancBirsoy identifying FLVCR1 as a mammalian choline transporter! Congratulations to everyone involved in this fun project!.
Our (now published) work identifying the major mammalian choline transporter by fantastic @TimCKenny @RockefellerUniv
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Congratulations @SteveBrohawn and @kerndm on the new story! Really exciting to how much you have been able to learn about the heteromeric channels and their regulation by lipids.
Great to see our story led by @kerndm on LRRC8A:C volume regulated anion channels in its final form! Lots of new data since the preprint including structures of a mutant that disrupts lipid block of the pore to activate the channel .
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RT @Alushin_Lab: After a pandemic hiatus, @BhabhaEkiertLab and I are pleased to organize the next iteration of the NY Area cryo-EM meeting,….
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