Excited that our study on a unified framework for joint-tissue transcriptome-wide association and MR analysis is now out @NatureGenet Huge thanks and congrats to postdoc @zdangm and colleagues at @VUMCgenetics @UpstateNews

Our new work in @Cell_Metabolism by @ArtemAKhan describes three new SLC transporters, including SLC25A45, a mitochondrial transporter for methylated amino acids that is essential for carnitine synthesis and fasting adaptation. @RockefellerUniv

Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @Cell_Metabolism @RockefellerUniv

Thank you so much to @patrickhu and all the other amazing folks, including @NancyGenetics, @AlexBickMDPhD, @ZinkelLab, @egamazon, from the @VUMC_MedPSTP + @VUMCDiscoveries I had the privilege to interact with as the Harrison Society Visiting Professor!

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis

So excited to announce publication of our research paper "Myeloid-Specific JAK2 Contributes to Inflammation and Salt Sensitivity of Blood Pressure" in @CircRes @AHAScience @nih_nhlbi! https://t.co/6CaZiUxrpq Congrats @saleemMMH @ashleylpitzer @LErtuglu @DoctorAlbritton

1. The layman summary of our recent publication @CircRes 1. We study why some people's blood pressure goes up when they eat too much salt. We found that certain immune cells, called antigen-presenting cells (APCs), play an important role in this process. https://t.co/2QoMnkwvMK

So awesome to hang out with wildly successful lab alumnus @AlexBickMDPhD, the new Division Director of Genetic Medicine @VUMC_Medicine!

A study in @NatureGenet presents a multiomic GeneMAP platform for discovery of metabolic gene function and identifies SCL25A48 GENE as a mediator of mitochondrial choline import. https://t.co/SxulnBDkuo

Recently, at least three research groups independently discovered a mitochondrial membrane choline transporter protein, SLC25A48. Two of the discoveries were through GWAS of plasma and urine choline levels. A nice example of human genetics → new biology. I wrote a small blog

New work from our lab’s genomics guru @ArtemAKhan with @egamazon. Artem generated a new platform for metabolic gene discovery and identified the mitochondrial choline transporter. @RockefellerUniv @NatureGenet

I am thrilled to share that our recent study on the development of a metabolic gene function discovery platform is now online on Nature Genetics. https://t.co/Ti3RDpMTSG.

I would like to thank @KivancBirsoy and @egamazon for their mentorship, all the coauthors for their valuable input as well as @RockefellerUniv and Boehringer-Ingelheim PhD Fonds for providing me with the funding and the resources.

A few thoughts on the recent set of papers torture testing genomic deep learning for predicting individual-level gene expression [ https://t.co/rRUBH7sW6m , https://t.co/ZLcoXGPbWD , https://t.co/Je9pFg4kX2 ]. First a brief summary 🧵: https://t.co/yUKnoeeA4r

A picture of Cambridge every day since 2010. (No 5000) Tuesday 5th December 2023. So here it is - my final picture of uninterrupted daily photographs of Cambridge - 5,000 consecutive posts over 13 years. I’m sure you’ll forgive the fact that it wasn’t taken today but a week ago

Combining health records from primary and secondary care we identified >5k cases @uk_biobank and identified 3 genomic risk loci 🧬 replicated findings in @EastLondonGenes and @VUMChealth

🚨Paper alert🚨 There are hundreds of disease that are common, but understudied. We linked electronic health records with #Genetics @uk_biobank and identified the first risk genes for #Raynauds phenomenon that causes painful vasospasms @WeAreSRUK https://t.co/RDI7sr1yF5

It's always exciting and thrilling to read about the GWAS discoveries of low-hanging fruits. Recently, two research groups have gotten their hands on a GWAS signal near ADRA2A that turned out to be a strong genetic risk factor for Reynaud's phenomenon. The first preprint by

Excited to share our work, just out & featured in @NatMachIntell We develop a ML approach for gene expression imputation across cell types/tissues. With Ramon @bidumit @pl219_Cambridge @chaitjo @DobrikG Phillip @VUMCgenetics @Cambridge_CL @cancer_dynamics https://t.co/gO4VfnZI8z

I always questioned when do you really **need** hypergraph GNNs? For modelling biological interactions beyond pairs, such as gene expression: HYFA processes gene expression values for patients collected from multiple organs. Paper: https://t.co/EcHQv7xsPJ

Excited to share the final version of our work out now in @Cell_Metabolism! Our new data show that choline loss severely impacts mitochondrial ultrastructure and membrane potential. We also partially rescue the embryonic lethality of Flvcr1 KO mice with choline supplementation