Hanyaloglu GPCR Lab
@Hanyaloglu_Lab
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@ImperialCollege Using biochemical & biophysical techniques to elucidate the action + regulation of GPCRs in various physiological systems.
London, England
Joined April 2018
In our 2nd interview to mark Women at Imperial Week, MDR's Dr @ElitaJaun gave the career advice: "Build your support network with peers you can trust and support each other and share experiences as you go through the ups and downs of your career." https://t.co/2GJt2RVQwG
#IWD25
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Congratulations to our superstar Dr @AnnabelleJ22 on passing her PhD with flying colours! We are so proud of you. 🎉🍾 Big thank you to examiners Bryn Owen and @Thue_Schwartz , and to Thue for also giving a wonderful seminar. @ImperialMDR @imperial_mrcdtp
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Huge congratulations to Professors @Deborah_Ashby, @p_openshaw & Catherine Williamson for their election to the Academy of Medical Sciences (@acmedsci) Council! 🎉 Their leadership reinforces @imperialcollege's role in tackling #GlobalHealth challenges.
imperial.ac.uk
Three Imperial College London academics have been elected to the Council of the prestigious Academy of Medical Sciences.
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Our new paper on #PCOS just published in @NaturRevEndo ⬇️
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PhD studentships now available in all areas of Life Sciences at @imperialcollege
https://t.co/sWJPgyW4hR
findaphd.com
Apply for a PhD: Department of Life Sciences funded PhD studentships at Imperial College London
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Countdown to our European Meeting next week, which will take place at Imperial College Business School 🙌🏼
Last chance to register for the European Ageing and Nutrition Sensing meeting in London ! Registration is closing this Thursday 7th November. Register using the link https://t.co/Ndj4n4t0oR
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Delighted to share our paper out today as part of our BBSRC-funded collaboration with @warwickuni. Here we describe how location of PGE2-driven cAMP signaling is critical for the human uterine endometrium to decode signals for decidualization. https://t.co/0qKMR18tRP
cell.com
Health sciences; Medicine; Medical specialty; Internal medicine; Endocrinology; Reproductive medicine
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Two exciting #postdoc opportunities for #microscopy #developers and #biologists to join our team @COMPARE_UoBUoN @unibirmingham! The @wellcometrust-funded project aims to develop a #AI driven #automated platform for high-throughput 5D #imaging applied to #GPCR #signaling!
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I’m very excited to finally present something we’ve been working on for the past couple of years – a spatial proteome map of primary cilia, released in @ProteinAtlas today. Amazing teamwork led by @jn_hansen Check out our preprint
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Many congratulations to our very own @OquaAffiong who passed her PhD viva today! @CellBiolMDR @ImperialMDR
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Special mention to @LilianeEleid, a @DiabetesUK funded PhD student and first author of the study @DUK_research @ImperialMDR @CellBiolMDR
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Thrilled to announce our latest preprint where we characterise the GLP-1R missense variant A316T in vivo in a humanised GLP-1R knock-in mouse and resolve the cryo-EM structure of the variant receptor. Many thanks to @DiabetesUK for funding this study. https://t.co/9ZfPhuZT9h
biorxiv.org
Glucagon-like peptide-1 receptor (GLP-1R) agonists are a highly effective therapy class for type 2 diabetes (T2D) and obesity, yet there are variable patient responses. Variation in the human Glp1r...
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Congrats to @AygulDagbasi & @Adrian_Holliday for leading this review article we had a small part in, on Anorexia of Ageing & how little we understand mechanistically. Free 50 day access here: https://t.co/4LFEGkUYgA
@AgeingNetwork @gfrost59 @ImperialMDR
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Meet Professor Phil Bennett who recently started his new role as Acting Head of MDR. In this interview, he shares his academic and professional journey, his vision for the Department and his reflections on the challenges and rewards of his work ⬇️ https://t.co/NN6pqpFeAQ
imperial.ac.uk
Professor Phil Bennett recently started his new role as Acting Head of the Department of Metabolism, Digestion and Reproduction.
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Each month an #egg is ovulated from the #ovary, starting the journey of reproduction. But how does ovulation occur?🥚 Our latest work in @NatureCellBio led by @LastChrisThomas and @Tabea_Marx, describes the control of #ovulation using live imaging. https://t.co/EYjwLfdAdy (1/7)
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Our latest out today @Nature! We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬 https://t.co/mfx6Hk7nma
nature.com
Nature - Two waves of glucose metabolism provide distinct ERK-mediated cellular signals during gastrulation, which regulate cell fate and specialized cellular functions that are necessary for...
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IES Committee would like to thank Dr Helen Wallace (local organizer) for hosting us, collaboration with @Soc_Endo @bioscientifica, for the success & smooth running of first Joint Irish-UK Endocrine Meeting. IES would not have been able to do this without you #IESSfE2024 #Belfast
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I’m currently advertising a 3 year funded PhD studentship opportunity in my laboratory. Project is on ovarian ageing. Please see below link for further project info and details on how to apply. RTs appreciated! https://t.co/QZBZj7g3jj
@SRF_Repro @lifecourse_KCL
kcl.ac.uk
The ovary ages faster than other organ, yet the mechanisms remain poorly defined. This project will elucidate how ovarian-hormone interactions change during ageing, via multiomics and mouse…
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Interested in doing a PhD in reproductive biology? Look no further! 👇
I’m currently advertising a 3 year funded PhD studentship opportunity in my laboratory. Project is on ovarian ageing. Please see below link for further project info and details on how to apply. RTs appreciated! https://t.co/QZBZj7g3jj
@SRF_Repro @lifecourse_KCL
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Excited to share a new preprint about my postdoc work in the von Zastrow lab! Using conformational biosensors, we investigated the mechanism by which the mu-opioid receptor increases G protein activity on endosomes.
biorxiv.org
Many GPCRs initiate a second phase of G protein-mediated signaling from endosomes, which inherently requires an increase in G protein activity on the endosome surface. Gs-coupled GPCRs are thought to...
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