davide calebiro
@DavideCalebiro
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Medical doctor, endocrinologist turned into pharmacologist, loves GPCRs and biophysics, jazz music, good wine. Opinions my own.
Birmingham, England
Joined January 2017
1/ I am excited to share our study describing a new modality of #intracrine #signalling by a #metabolite-sensing #GPCR published today with @SpringerNature in @NatChemBiol! @UoB_MSS @COMPARE_UoBUoN @UoBmedicalsci @unibirm_CMH
https://t.co/Mhvx7OQoIz 🧵👇
nature.com
Nature Chemical Biology - An ‘intracrine’ signaling mechanism is proposed whereby a G-protein-coupled receptor (free fatty acid receptor 4) senses locally released fatty acids on...
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Join us for Prof Dan Tennant's inaugural lecture, entitled "Imposters: a story of mitochondria and me". Dan will discuss his love of all things mitochondrial and metabolism, research and how he became the scientist he is today. Open to all. Register: https://t.co/bp4tCkFDtv
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Great PhD opportunity with @AJWilsonGroup and our own group to develop innovative chemical probes to study #endosomal #GPCR #signalling Apply now!
Its PhD application season! Check out this project with the amazing @DavideCalebiro on chemical probes for GPCRs -
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Excellent representation of our @UoB_MSS @UoBmedicalsci @unibirm_CMH @uhbtrust @UHBCancer adrenal team at the #adrenalcancer oral session at @ENSAT_news annual meeting 2025! Well done everyone @CryRonchi @emre_saygili Joshua Bain, Emanuela Esposito, Abubaker Mohamed @DocTux92 👏
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Impression of the amazing final Masterclass of the EU Cost Action @goharmonisation and reception today in #Belgrade! Well done to the LOC and the Harmonisation team 👏 #adrenaltumour #networking #education #teamwork
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All the best to MSS colleagues in Serbia over the next few days for the 24th Annual Meeting of the European Network for the Study of #Adrenal Tumours & EU Cost Harmonisation activities. Opening proceedings is @ENSAT_news President @CryRonchi & others will present talks/posters!
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Our very own @CryRonchi and @AlePreteUoB representing @UoB_MSS @UoBmedicalsci @unibirm_CMH and @UHBCancer @uhbtrust Adrenal Team at the national Serbian @AdvanceAdrenal #adrenal tumour symposium in #Belgrade 👏👏👏 #adrenalcancer #MACS
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A useful webinar coming up this October 4th for patients with Adrenocortical carcinoma #ACC and featuring our very own @CryRonchi. Don’t miss it!
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Great news: our early bird discount for Endocrine Metabolic GPCRs has been extended until 9 Sept! Save up to 20% for a whole day of exchanging technologies and ideas on G protein-coupled receptors Time is ticking though so book your place today! https://t.co/hSRncjP0s8
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8/ Big thanks to our amazing team & collaborators! @Thue_Schwartz @ProfGMilligan @Michel_Bouvier @Z_GerhartHines Follow for more 🧬🔬 #GPCR #Science #Metabolism #Diabetes #Obesity
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7/ 📄Read our paper: "Intracrine FFA4 signaling controls lipolysis at lipid droplets" 👉
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6/ 💡 Why does this matter? Understanding this mechanism could lead to: ✅New anti-obesity therapies ✅Smarter diabetes drugs that regulate fat storage and/or release ✅A new way to target metabolism right where it happens
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5/ Our findings reveals a novel modality of 🔬 '#Intracrine' signalling, which could also be relevant to other metabolite-sensing #GPCRs
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4/ When fat is broken down, the released fatty acids immediately activate these #intracellular #FFA4 #receptors. This triggers a local “brake” on fat breakdown, letting each lipid droplet regulate its #metabolism.
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3/ We studied #FFA4, a receptor that detects fatty acids. Surprise: #FFA4 isn’t just on the cell surface. It sits inside fat cells, right next to #lipid droplets (the fat stores in #adipocytes)!
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2/ Fat cells store energy as fat. When the body needs energy, they break down fat into free fatty acids – a process called #lipolysis. But lipolysis must be tightly controlled. Too much fat release can lead to #diabetes and #heart #disease.
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SAVE THE DATE Birmingham Endocrine Seminars 2025 - Endocrine Cancer 13th October 2025, 3.30-6.30pm UK time. @UoB_MSS @unibirm_CMH Excellent opportunity to gain knowledge on common and rare endocrine cancers by experts on the field. Link for registrations https://t.co/nfcnJy5Wrr
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Great time at #ENDO2025 Glad to see such active @UoB_MSS participation! Amazing programme brought about by our own conference chair Niki Karavitaki! @UoBmedicalsci @unibirm_CMH @TheEndoSociety
Another exciting day at #ENDO2025 @TheEndoSociety! Today MSS researcher Caroline Gorvin @caroline_gorvin presented her work on calcium sensing receptor mutations. One more day of the conference to go!
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Huge congratulations to our @unibirmingham @UoBmedicalsci @UoB_MSS @uhbtrust @Karavitaki_Niki presenting at the opening session of @TheEndoSociety #ENDO2025 as annual meeting chair 👏👏👏
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