In PNAS researchers have used a combinatorial protein library that allow for selection of calcium dependency to select binders against the cancer receptor EGFR , an approach that generates fine-tuned binders and possibly enable new treatment regimes. https://t.co/g5NbKDMrhq

This year's Nobel Prize in Physiology and Medicine was awarded discoveries concerning peripheral immune tolerance and regulatory T cells. These immune cells play an important role in protection from autoimmune diseases and FOXP3 is key to their function. https://t.co/r4vqIlUkDn

In an article in Genetic Engineering and Biotechnology News, Gustav Ceder shares his impressions from the HUPO world congress in Toronto and the thoughts and perspectives from some of the big players in the proteomics field. https://t.co/MrNnhDHAQp

At the HUPO meeting in Toronto HPA members contributed more than 25 talks and posters. Loren Méar was selected as a poster competition finalist for her work "Spatial proteomics uncovers structural and molecular complexity of the human ovary in 2D and 3D." https://t.co/zb5wgz4SM4

Specific expression of the largely uncharacterized protein TMEM52B (green) in the apical part of the cytoplasm of distal tubular cells (red) highlighted with multiplex immunohistochemistry. Other visualized structures include the proximal tubules (white). https://t.co/6jUYRgb2Hn

Version 25 of the Human Protein Atlas is launched. New additions are Olink HT and SomaScan data for 32 cohorts including diseases and childhood development, more single cell data with 4 new tissues and 23000 predicted structures for protein interactions https://t.co/48Ms1j5FPT

It is Movember and prostate cancer is in the spotlight. Explore prognostic genes associated with survival based on transcriptomics data and find out more about prostate cancer gene expression and cell line models in the Human Protein Atlas Cancer resource. https://t.co/dwINLysyDK

An article in PNAS investigates factors influencing recombinant protein expression in CHO cells showing that transgene mRNA abundance is not important, while MW, disulfide bonds, cysteine composition and N-linked glycosylation have the strongest effect. https://t.co/9nhmadvgvX

Join our project “Embedding Multimodal Data in a Vector Database to Build a Blood Atlas” remotely for the BioHackathon Europé 2025! Join the project kick-off meeting October 28 at 16:00 CET. Passcode: B8GwzS https://t.co/quXFTn6tyQ

A study in Nat. commun. added OPTN as a player in the Golgi membrane-associated degradation GOMED. In HPA this ubiquitin-binding adaptor protein localize in a punctate pattern in the perinuclear region of the cytoplasm where the Golgi apparatus resides. https://t.co/or6Sw99N34

CYLC1 a cytoskeletal protein associated with the 'head' structure of the sperm is visualized in late stage spermatogenesis with mIHC/IF and shown to be mainly localized (green) to the cytoplasm of cell state 2 (red) and 3 (white) of late spermatids. https://t.co/daBU9THeA6

In a study in Science, a team of researchers have mapped how thousands of proteins in human blood shift as a result of aging and diseases. The molecular "fingerprints" from 59 diseases can enable blood tests to discern troubling signs from common. https://t.co/q2uRijNMod

In the journal Cell a deep analysis of the HPA primary cilia section is published. The primary cilia is portrayed as the most heterogeneous organelles, customized by the cell for fine-tuned environmental sensing, inspiring new views on this tiny antenna. https://t.co/b7xhxA9wov

Transcription factors SP5 and SP8 were recently shown to regulate primary cilia formation during embryogenesis. In the HPA subcellular resource they localize to the nucleus of human cell lines. https://t.co/nuzWMki3DI

In a publication in PLOS One a deep learning model was successfully used to segment epithelial cells and identify invasive epithelial cells in tissue sections from breast cancer patients using IHC stainings as ground truth. https://t.co/fB2dMiD6WH

In depth-profiling of the expression of the antimicrobial iron-binding transport protein lactotransferrin ( LTF) in salivary gland reveals distribution in small ducts and serous acini of the ductal system. https://t.co/P4rjZIp0oL

In a review in Mol. Syst. Biol. recently generated big biology datasets and the application of AI and systems biology in integrating multi-omics data to enhance precision health and medicine are discussed. https://t.co/Tb9NPV7wHm

In an article in Immunity researchers analyzed plasma proteins in malaria and by integrating the profiles with single-cell RNA-seq data they were able to link responses to peripheral immune cells and identify a protein profile enriched in severe malaria. https://t.co/8con1NfZrY

Hepatocellular carcinoma is a high mortality cancer and many patients are immunotherapy resistant due to β-catenin mutations. A study in Nat. Comm. show RNAi-mediated β-catenin inhibition delivered by a lipid nanoparticle to be a promising way forward. https://t.co/fQVgUVPfdt

Here Ciliogenesis-associated regulatory factor X2 (RFX2), a transcription factor believed to regulate the transcription of motile cilia genes together with FOXJ1, is visualized in ciliated epithelium of the nasopharynx. https://t.co/V9fhnA77EX