Gunning Group
@GunningLabUofT
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Multidisciplinary team of molecular architects using #medicinalchemistry & #molecularrecognition to design better medicines. 🧵 gunninggroup 🐘 gunninglabuoft
Mississauga, Ontario
Joined December 2019
Thrilled to share our #OpenAccess online resource "An Introduction to Medicinal Chemistry & Molecular Recognition" on @OpenLibraryON! We designed this resource to provide budding medicinal chemists with the knowledge & tools to navigate small molecule drug discovery! #OER
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Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research https://t.co/XHntu0xNIZ
https://t.co/XhpAn16HaI
@NEJM
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NEW SITE LAUNCH! https://t.co/aJ9BgdKfVn NEW! Researchers & Scientists: https://t.co/DOvaQq3FHH NEW! Patient & Caregiver Resources https://t.co/159YcwPM18 NEW! Projects Funded https://t.co/CpyaXUbkch NEW! Community https://t.co/ssmRrYQE6Y
#braincancer
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In case you missed it: 'Microwave-assisted synthesis of pomalidomide building blocks for rapid PROTAC and molecular glue development' Fom Patrick Gunning and colleagues at @GunningLabUofT
https://t.co/URQzvQhoNo
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Monoselective Histone Deacetylase 6 PROTAC Degrader Shows In Vivo Tractability | Journal of Medicinal Chemistry
pubs.acs.org
Herein, we report a potent HDAC6 PROTAC, TO-1187, which selectively degrades HDAC6 in cellulo and demonstrates in vivo efficacy. The design of TO-1187 was achieved by linking our previously reported...
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Congratulations to first authors Harsimran Garcha and @OlutobiOlaoye, co-authors @Taleb_Sedighi, Daniel Pölöske, Pearla Hariri, Wenlong Yu, @d_abdallah98, & our longtime friend and collaborator @richard_moriggl for this work! @Patrick_Gunning @e_dearaujo
pubs.acs.org
Herein, we report a potent HDAC6 PROTAC, TO-1187, which selectively degrades HDAC6 in cellulo and demonstrates in vivo efficacy. The design of TO-1187 was achieved by linking our previously reported...
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Excited to share our latest work on an exquisitely selective #PROTAC of #HDAC6 in #JMedChem @ACSBioMed @ACSPublications!! TO-1187 is a highly potent HDAC6 degrader with complete proteome selectivity, sparing all #CRBN neosubstrates and other #HDAC isoforms.
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Congratulations to first authors @d_abdallah98 and @brohannes10, co-authors Lina Hasan, Naman Patel, Timothy Wright, @bilalsaqib_, and many thanks to our collaborator @theKeillors for this excellent work! @Patrick_Gunning @e_dearaujo
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We optimized conventional conditions for fluorothalidomide SNAr (overnight, oil bath heating) to achieve improved yields on gram-scale in only 15 minutes under microwave irradiation, exemplifying the method by preparing the clinically explored PROTAC #bavdegalutamide (ARV-110)!
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Do you find multi-step #PROTAC synthesis to be laborious and time-consuming? We present our latest work in @ChemCommun on a microwave-assisted #SNAr methodology for rapid preparation of #pomalidomide-based #PROTACs! #targetedproteindegradation #molecularglues
Take a look at 'Microwave-assisted synthesis of pomalidomide building blocks for rapid PROTAC and molecular glue development' New from Patrick Gunning and colleagues at @GunningLabUofT
https://t.co/URQzvQhoNo
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Check out our paper on proton pump inhibitor activation in cells in @NatureChemistry. Congrats to first author Teresa Marker who started this project in my group and finished it with Tobias Dick (@RedoxDKFZ). More collabs between our groups @DKFZ to come! https://t.co/oYt2rHEF0D
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🗞️ "Characterization of conformational states of the homodimeric enzyme fluoroacetate dehalogenase by 19F–13C two-dimensional NMR" ⤵️ @UofT &+ With #NSERCsupport.
Excited to share our new paper in @rsc_chembio on improving resolution in fluorotryptophan protein NMR by expanding into the 13C dimension! We prepared & used a 13C-labelled F-Trp precursor to achieve unprecedented spectral resolution of a F-Trp-bearing protein by 2D 19F-13C NMR!
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Congrats to Motasem in the #Prosserlab and our recent co-supervised alumnus @geordifrere for publishing a new story on tryptophan-based 2D 19F-13C NMR in @rsc_chembio!
Excited to share our new paper in @rsc_chembio on improving resolution in fluorotryptophan protein NMR by expanding into the 13C dimension! We prepared & used a 13C-labelled F-Trp precursor to achieve unprecedented spectral resolution of a F-Trp-bearing protein by 2D 19F-13C NMR!
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We're hiring a #Postdoctoral Fellow in #medicinalchemistry in collaboration with @HDAXtx! Please repost and apply below if you're interested in advancing our novel small-molecule therapeutics! #chemjobs #chempostdoc #postdoc #postdocjobs @ChemPostdocBot
https://t.co/PORxafv7to
linkedin.com
Today’s top 3,000+ Postdoctoral Research Assistant jobs in United States. Leverage your professional network, and get hired. New Postdoctoral Research Assistant jobs added daily.
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pharmacophore-optimized photoaffinity fragments-based hit discovery with improved hit rate and better sensitivity, and multiple binding sites, reported by @keserulab @GunningLabUofT
https://t.co/HbHZWUUyqY
nature.com
Communications Chemistry - Fragment screening is a popular strategy for generating viable chemical starting points for drug targets, however, weak affinity to targets, as well as the exploration of...
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Congratulations to our Sr. Researcher Associate @GeletuMulu for receiving the Rosemary Brown Outstanding Mentorship Award at @CanBlackSci's #BlackExcellenceInSTEMM conference!! Mulu's commitment to scientific mentorship in our community is nothing short of inspiring. #BESTEMM2024
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@NSERC_CRSNG @UTM_CPS @J_A_C_S @TheMediumUTM Geordi has been a pillar of our lab and the larger @UTM community in many capacities throughout his graduate studies. We wish him the absolute best as he heads to @harvardmed to pursue an exciting postdoc in the @GygiLab @HarvardCellBio! #gunningalumni
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@NSERC_CRSNG @UTM_CPS @J_A_C_S You can read more about Geordi's graduate journey by reading @TheMediumUTM's article featuring him! He discusses his path towards chemistry, describes the joy and wonder of creating new molecules, and shares some advice for prospective graduate students. https://t.co/3XPlnBMrOC
Our PhD student @geordifrere was featured in the latest issue of @TheMediumUTM! Geordi is a talented medicinal chemist in our lab working on the development of covalent protein degraders as well as new ways to enable site-selective ligand discovery by NMR! https://t.co/OIC8ZaILtL
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@NSERC_CRSNG @UTM_CPS Always keen to push the limits of #19FNMR, he introduced a new design paradigm for NMR tags in @J_A_C_S showing that chemical shift response can be amplified by placing the NMR reporter within a dynamic chemical system such as the tautomeric 2-pyridone.
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Geordi's innovative research on tunable #covalent chemistry led to the creation of monovalent #TPD biotech #Dunad Therapeutics, & his research on next-generation fluorine NMR has been supported by OGS, @NSERC_CRSNG CGS-M & CSG-D, & our @UTM_CPS departmental Huguette Cohen Award!
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Delighted to congratulate Dr. @geordifrere for defending his PhD thesis on the design of #monovalent electrophilic protein degraders & novel probes for protein-observed 19F #NMR! Geordi is an expert synthetic chemist & our resident scientific lectiophile! #PrOFNMR #covalent #TPD
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