Gunning Group
@GunningLabUofT
Followers
2K
Following
3K
Media
148
Statuses
2K
Multidisciplinary team of molecular architects using #medicinalchemistry & #molecularrecognition to design better medicines. 🧵 gunninggroup 🐘 gunninglabuoft
Mississauga, Ontario
Joined December 2019
Thrilled to share our #OpenAccess online resource "An Introduction to Medicinal Chemistry & Molecular Recognition" on @OpenLibraryON! We designed this resource to provide budding medicinal chemists with the knowledge & tools to navigate small molecule drug discovery! #OER
1
20
57
RT @EricTopol: Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism".—the 1st hu….
0
624
0
RT @ChemCommun: In case you missed it:. 'Microwave-assisted synthesis of pomalidomide building blocks for rapid PROTAC and molecular glue d….
0
2
0
RT @Glaconde34: Monoselective Histone Deacetylase 6 PROTAC Degrader Shows In Vivo Tractability | Journal of Medicinal Chemistry https://t.c….
pubs.acs.org
Herein, we report a potent HDAC6 PROTAC, TO-1187, which selectively degrades HDAC6 in cellulo and demonstrates in vivo efficacy. The design of TO-1187 was achieved by linking our previously reported...
0
2
0
Congratulations to first authors Harsimran Garcha and @OlutobiOlaoye, co-authors @Taleb_Sedighi, Daniel Pölöske, Pearla Hariri, Wenlong Yu, @d_abdallah98, & our longtime friend and collaborator @richard_moriggl for this work! @Patrick_Gunning @e_dearaujo
pubs.acs.org
Herein, we report a potent HDAC6 PROTAC, TO-1187, which selectively degrades HDAC6 in cellulo and demonstrates in vivo efficacy. The design of TO-1187 was achieved by linking our previously reported...
0
2
5
Excited to share our latest work on an exquisitely selective #PROTAC of #HDAC6 in #JMedChem @ACSBioMed @ACSPublications!! TO-1187 is a highly potent HDAC6 degrader with complete proteome selectivity, sparing all #CRBN neosubstrates and other #HDAC isoforms.
1
5
24
Congratulations to first authors @d_abdallah98 and @brohannes10, co-authors Lina Hasan, Naman Patel, Timothy Wright, @bilalsaqib_, and many thanks to our collaborator @theKeillors for this excellent work! @Patrick_Gunning @e_dearaujo.
0
1
6
We optimized conventional conditions for fluorothalidomide SNAr (overnight, oil bath heating) to achieve improved yields on gram-scale in only 15 minutes under microwave irradiation, exemplifying the method by preparing the clinically explored PROTAC #bavdegalutamide (ARV-110)!.
1
1
5
Do you find multi-step #PROTAC synthesis to be laborious and time-consuming? We present our latest work in @ChemCommun on a microwave-assisted #SNAr methodology for rapid preparation of #pomalidomide-based #PROTACs! .#targetedproteindegradation #molecularglues.
Take a look at 'Microwave-assisted synthesis of pomalidomide building blocks for rapid PROTAC and molecular glue development'. New from Patrick Gunning and colleagues at @GunningLabUofT.
1
1
12
RT @DrugDiscov_DKFZ: Check out our paper on proton pump inhibitor activation in cells in @NatureChemistry. Congrats to first author Teresa….
0
19
0
RT @NSERC_CRSNG: 🗞️."Characterization of conformational states of the homodimeric enzyme fluoroacetate dehalogenase by 19F–13C two-dimensio….
0
3
0
Congrats to Motasem in the #Prosserlab and our recent co-supervised alumnus @geordifrere for publishing a new story on tryptophan-based 2D 19F-13C NMR in @rsc_chembio!.
Excited to share our new paper in @rsc_chembio on improving resolution in fluorotryptophan protein NMR by expanding into the 13C dimension! We prepared & used a 13C-labelled F-Trp precursor to achieve unprecedented spectral resolution of a F-Trp-bearing protein by 2D 19F-13C NMR!
0
3
14
We're hiring a #Postdoctoral Fellow in #medicinalchemistry in collaboration with @HDAXtx! Please repost and apply below if you're interested in advancing our novel small-molecule therapeutics!.#chemjobs #chempostdoc #postdoc #postdocjobs @ChemPostdocBot.
linkedin.com
Today’s top 2,000+ Postdoctoral Research Assistant jobs in United States. Leverage your professional network, and get hired. New Postdoctoral Research Assistant jobs added daily.
0
13
25
RT @CommsChem: pharmacophore-optimized photoaffinity fragments-based hit discovery with improved hit rate and better sensitivity, and multi….
nature.com
Communications Chemistry - Fragment screening is a popular strategy for generating viable chemical starting points for drug targets, however, weak affinity to targets, as well as the exploration of...
0
5
0
Congratulations to our Sr. Researcher Associate @GeletuMulu for receiving the Rosemary Brown Outstanding Mentorship Award at @CanBlackSci's #BlackExcellenceInSTEMM conference!! Mulu's commitment to scientific mentorship in our community is nothing short of inspiring. #BESTEMM2024
0
2
17
@NSERC_CRSNG @UTM_CPS @J_A_C_S @TheMediumUTM Geordi has been a pillar of our lab and the larger @UTM community in many capacities throughout his graduate studies. We wish him the absolute best as he heads to @harvardmed to pursue an exciting postdoc in the @GygiLab @HarvardCellBio! #gunningalumni.
0
1
7
@NSERC_CRSNG @UTM_CPS @J_A_C_S You can read more about Geordi's graduate journey by reading @TheMediumUTM's article featuring him! He discusses his path towards chemistry, describes the joy and wonder of creating new molecules, and shares some advice for prospective graduate students.
Our PhD student @geordifrere was featured in the latest issue of @TheMediumUTM! Geordi is a talented medicinal chemist in our lab working on the development of covalent protein degraders as well as new ways to enable site-selective ligand discovery by NMR!.
1
2
9
@NSERC_CRSNG @UTM_CPS Always keen to push the limits of #19FNMR, he introduced a new design paradigm for NMR tags in @J_A_C_S showing that chemical shift response can be amplified by placing the NMR reporter within a dynamic chemical system such as the tautomeric 2-pyridone.
1
1
7
Geordi's innovative research on tunable #covalent chemistry led to the creation of monovalent #TPD biotech #Dunad Therapeutics, & his research on next-generation fluorine NMR has been supported by OGS, @NSERC_CRSNG CGS-M & CSG-D, & our @UTM_CPS departmental Huguette Cohen Award!.
1
0
4
Delighted to congratulate Dr. @geordifrere for defending his PhD thesis on the design of #monovalent electrophilic protein degraders & novel probes for protein-observed 19F #NMR! Geordi is an expert synthetic chemist & our resident scientific lectiophile!.#PrOFNMR #covalent #TPD
2
3
28